Laparoscopic Replacement of Urinary Tract Segments Using Biodegradable Materials in a Large-Animal Model

Shalhav, Arieh L.; Elbahnasy, Abdelhamid M.; Bercowsky, Eduardo; Kovács, Gábor; Brewer, Allison V.; Maxwell, Keegan L.; McDougall, Elspeth M.; Clayman, Ralph V.

doi:10.1089/end.1999.13.241

Cited by 83 publications

(34 citation statements)

References 12 publications

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“…When intraluminal pressure is low and there is positive intraabdominal pressure compression on the graft, the graft may collapse. These similar results had been reported in segmental esophagus, ureter, and small intestine replacement with SIS [16][17][18]. On the contrary, the PGA-PLGA copolymer had an inherited strength before the degradation of the synthetic fibers.…”

Section: Discussionsupporting

confidence: 87%

Bladder autoaugmentation using various biodegradable scaffolds seeded with autologous smooth muscle cells in a rabbit model

Lai

Chang

Lin

2005

Journal of Pediatric Surgery

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Section: Discussionsupporting

confidence: 87%

Bladder autoaugmentation using various biodegradable scaffolds seeded with autologous smooth muscle cells in a rabbit model

Lai

Chang

Lin

2005

Journal of Pediatric Surgery

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“…SIS has been previously demonstrated to be an unsuccessful ureteral replacement material in a study by Shalhav et al [24]. At 12 weeks, the graft material had a stricture formation rate of 100% in the six pigs studied.…”

Section: Original Researchmentioning

confidence: 89%

Ureteral Segment Replacement Using a Circumferential Small-Intestinal Submucosa Xenogenic Graft

Jaffe

Ginsberg

Yanoshak

et al. 2001

Journal of Investigative Surgery

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We wished to determine whether small-intestinal submucosa (SIS) will epithelialize when used as a ureteral replacement material. An 11-mm segment of native ureter was excised from eight New Zealand White rabbits and replaced with an 11-mm porcine SIS graft, which was circumferentially wrapped around a ureteral stent. The SIS ureteral grafts were harvested at 11 days or 35 days postimplantation and examined grossly and by standard light microscopy techniques. Partial epithelialization with the ingrowth of urothelium, smooth muscle cells, and blood vessels was observed in the grafts harvested at 11 days postimplantation. The SIS ureteral grafts examined at 35 days postimplantation showed additional restructuring of the smooth muscle cell layer and more organized epithelialization in comparison to the SIS graft examined at 11 days. After 35 days of regenerative healing, elements of all three layers of the native ureter were observed within the collagen matrix of the SIS graft. No significant complications were observed, but all subjects (8/8) demonstrated mild intra-abdominal adhesions. Mild collecting system dilatations were observed in 4/4 (100%) of the animals harvested at 35 days and in 0/4 (0%) of the animals harvested at 11 days. We have this demonstrated in this preliminary study that SIS xenografts will epithelialize when used as a ureteral replacement material. The repair mechanism of these ureteral grafts occurred through a regenerative healing process rather than by scar formation. With further studies, this material may prove to be a useful treatment option in patients with ureteral injuries.

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“…The polarographic studies showed that the preferred substrate of bladder tissue is succinate, because of the low complex I activity in this tissue. A study in larger animals should be attempted; studies on enlarging the bladder of the dog [2,17,18] and of the pot-bellied pig [19] have already shown that this type of surgery is possible, and that histologically normal bladder tissue can be thus obtained.…”

Section: Discussionmentioning

confidence: 99%

Mitochondrial metabolism in the rat during bladder regeneration induced by small intestinal submucosa

et al. 2004

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OBJECTIVETo assess mitochondrial metabolism of bladder tissue induced by small‐intestinal submucosa (SIS), by comparing the mitochondrial enzyme metabolism in this tissue with that in normal bladder tissue and thus evaluate intracellular normality.MATERIAL AND METHODSIn all, 70 rats were grouped into healthy controls (10), surgical controls with a simple bladder incision (15) and rats treated by partial cystectomy with replacement by the SIS graft (45). At 1, 3 and 6 months the rats were killed, the enzymes of mitochondrial respiratory chain complexes assayed, and the respiration of permeabilized bladder fibres assessed using polarographic analysis.RESULTSThe enzyme activities of control and treated rats at 3 months were identical. The results from the polarographic analysis of respiration were also similar to that in normal tissue apart from a decrease in the number of mitochondria. Histologically, there was complete regeneration at 6 months.CONCLUSIONAfter a phase of inflammation the bladder regenerates after a patch is placed. The new tissue has the same enzymatic and histological features as normal bladder tissue.

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Laparoscopic Replacement of Urinary Tract Segments Using Biodegradable Materials in a Large-Animal Model

Cited by 83 publications

References 12 publications

Bladder autoaugmentation using various biodegradable scaffolds seeded with autologous smooth muscle cells in a rabbit model

Bladder autoaugmentation using various biodegradable scaffolds seeded with autologous smooth muscle cells in a rabbit model

Ureteral Segment Replacement Using a Circumferential Small-Intestinal Submucosa Xenogenic Graft

Mitochondrial metabolism in the rat during bladder regeneration induced by small intestinal submucosa

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