Laparoscopic Renal Denervation for Uncontrolled Hypertension Due to Medication Intolerance: A Case Report

Gerber, Rebecca C.; Bahler, Clinton D.; Kraus, Michael A.; Sundaram, Chandru P.

doi:10.1053/j.ajkd.2016.01.021

Cited by 7 publications

(7 citation statements)

References 7 publications

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“…In the absence of effective surgical treatment for resistant hypertension, a laparoscopic approach has been proposed as an alternative method to overcome the limitations of the catheter approach [20]. According to Gerber et al [20], the laparoscopic approach is capable of removing nerves that are typically not removed by RF-based catheter ablation. The claim by Gerber et al is promising, there have been no studies published to describe the surgical strategy or instrument design for the effective laparoscopy-based RDN system.…”

Section: Introductionmentioning

confidence: 99%

Design and simulation of novel laparoscopic renal denervation system: a feasibility study

Baik

Lee

et al. 2018

International Journal of Hyperthermia

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Section: Introductionmentioning

confidence: 99%

Design and simulation of novel laparoscopic renal denervation system: a feasibility study

Baik

Lee

et al. 2018

International Journal of Hyperthermia

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“…No side effects were found over the 6 years of follow-up. A similar case report published in 2016 [12], presented the case of a female patient with resistant hypertension who underwent laparoscopic RDN. RF ablation was not used in her case.…”

Section: Discussionmentioning

confidence: 73%

“…Moreover, this was an initial attempt at laparoscopic-based perivascular RDN. Therefore, to reduce the risk of injury, we performed unilateral RDN instead of bilateral RDN, as reported in the earlier case [12]. Despite this, the BP decreased considerably.…”

Section: Discussionmentioning

confidence: 95%

Laparoscopic-based perivascular unilateral renal sympathetic nerve denervation for treating resistant hypertension: a case report

et al. 2019

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A 38-year-old man with a history of resistant hypertension for more than 10 years underwent laparoscopic-based perivascular unilateral renal sympathetic nerve denervation in 2012. After the operation, the patient's blood pressure has been controllable while the antihypertensive drug intake has decreased over 6 years. Laparoscopic-based perivascular unilateral renal sympathetic nerve denervation may be a potentially feasible and effective option in treating patients with resistant hypertension.

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“…In 2016, a 59-yearold woman with blood pressures as high as 220/110 mmHg underwent bilateral laparoscopic renal denervation. Finally, the patient's blood pressure was reduced to the range of 120-140/80-90 mmHg at the 1-, 3-, 9-, and 12-month follow-ups [17]. Ye E et al designed a novel laparoscopy-based renal denervation (L-RDN) system with a looped bipolar electrosurgical instrument.…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic based renal denervation in a canine neurogenic hypertension model

Shao

Zhou

You

et al. 2020

BMC Cardiovasc Disord

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Background: Previous renal denervation (RDN) studies showed controversial results in reducing blood pressure. The aim of this study was to provide evidence supporting the effectiveness of laparoscopic-based renal denervation (L-RDN) in treating hypertension. Methods: Sixteen Beagle dogs were randomly divided into RDN group (n = 12) and sham group (n = 4). Neurogenic hypertension was generated in all dogs via carotid artery route. L-RDN was performed in the RDN group, with sham operation performed as a control. Blood pressure (BP) changes were recorded at 2, 4, 6, and 8 weeks after the procedure. Changes in serum creatinine (sCr), blood urea nitrogen (BUN) and level of norepinephrine (NE) were analyzed. Histological changes of kidney and renal arteries were also evaluated. Results: BP and NE levels were significantly elevated after hypertension induction (p < 0.01). Systolic and diastolic BP of RDN group were decreased by 15.5 mmHg and 7.3 mmHg (p < 0.0001 and p = 0.0021, respectively) at the eighth week after L-RDN. Invasive systolic and diastolic BP of RDN group were significantly decreased by 14.5 mmHg and 15.3 mmHg (p < 0.0001). In contrast, there was no significant decrease in blood pressure in the sham group. In addition, RDN group but not the sham group showed a significant decrease in NE levels (p < 0.001), while no significant changes in sCr and BUN were observed in both groups. Pathological examinations showed no discernible damage, tear, or dissection to the renal arteries in RND group. Conclusions: L-RDN lowered BP and NE levels in hypertensive dogs without affecting renal artery morphology and kidney function.

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Laparoscopic Renal Denervation for Uncontrolled Hypertension Due to Medication Intolerance: A Case Report

Cited by 7 publications

References 7 publications

Design and simulation of novel laparoscopic renal denervation system: a feasibility study

Design and simulation of novel laparoscopic renal denervation system: a feasibility study

Laparoscopic-based perivascular unilateral renal sympathetic nerve denervation for treating resistant hypertension: a case report

Laparoscopic based renal denervation in a canine neurogenic hypertension model

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