Laparoscopic radiofrequency thermal ablation of neuroendocrine hepatic metastases: Long-term follow-up

Radiofrequency Ablation for Neuroendocrine Liver Metastases: A Systematic Review

“…The Downs and Black checklist was modified by one of the present authors (H.M.) to allow it to be used to assess study quality for the present series of nonrandomized studies. With this modified score, a maximum score of 14 was possible, with higher scores reflecting higher quality of studies (Table E2 [ 14,15,[29][30][31][32][33][34], available online at www.jvir.org). In view of the low quality of studies in the present review, a meta-analysis was not performed.…”

GEP-NETS UPDATE: Interventional radiology: role in the treatment of liver metastases from GEP-NETs

“…After a median follow-up of 30 months, 89 patients (carcinoidZ55, pancreatic islet cellZ23, and medullary thyroid cancerZ11) with metastases measuring 3.6G0.2 cm and in a number of 6G1, treated with laparoscopic RFA, achieved 97% symptom relief with 22% local liver recurrence, 63% new liver metastases, and 59% extrahepatic disease. Median disease free survival (DFS) and OS were 1.3 and 6 years with liver tumor volume, symptoms, and extra-hepatic disease as independent predictive factors of survival (88). Consequently, only patients with a low tumor volume are amenable to RFA, with best indication for ablative therapies being metastases in small numbers, usually !5 and with a diameter below 3-3.5 cm, due to a maximum volume of destruction around 5 cm for currently available RFA systems, and the need to ensure the safety margins of 1-2 cm of ablation around the tumor.…”

Nowotwory neuroendokrynne trzustki — zasady diagnostyki i leczenia (rekomendowane przez Polską Sieć Guzów Neuroendokrynych)

“…This method enables the control of symptoms in over 90% of patients [166]. Radical excision of hepatic metastases is the "golden standard" in the therapy of advanced PNETs; therefore, resection should be performed whenever possible (*evidence level 4).…”