Laparoscopic near-infrared fluorescent imaging as an alternative option for sentinel lymph node mapping in endometrial cancer: A prospective study

Taşkın, Salih; Şükür, Yavuz Emre; Altın, Duygu; Ersöz, Cevriye Cansız; Turgay, Batuhan; Kankaya, Duygu; Güngör, Mete; Ortaç, Fırat

doi:10.1016/j.ijsu.2017.09.015

Cited by 19 publications

(7 citation statements)

References 17 publications

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“…However, it was not possible to reach higher numbers of such a specific condition with approximately 20% prevalence 3,4,7 in this single-center experience. The categorical variables are presented as frequency (percentage) and the continuous variables are presented as median (min-max).…”

Section: Discussionmentioning

confidence: 70%

“…1,7 The ICG/NIR compatible endoscopic systems were used in all surgeries (Spies Full HD D-Light P ICG technology; Karl Storz, Tuttlingen, Germany for laparoscopic and open surgeries, and da Vinci Xi robotic platform; Intuitive Surgical, California). Briefly, mapped SLNs were resected and any suspicious lymph node was removed regardless of mapping.…”

Section: Methodsmentioning

confidence: 99%

“…As we previously stated, presacral and para-aortic areas were observed for extrapelvic SLNs in cases with pelvic unmapping. 7 Results of our practice were presented with discussion of possible reasons of pelvic unmapping.…”

mentioning

confidence: 99%

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Extrapelvic Sentinel Lymph Nodes in Endometrial Cancer Patients With Unmapped Pelvic Side: A Brief Report

Taşkın

Altın

Şükür

et al. 2018

Int J Gynecol Cancer

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Section: Discussionmentioning

confidence: 70%

Section: Methodsmentioning

confidence: 99%

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Extrapelvic Sentinel Lymph Nodes in Endometrial Cancer Patients With Unmapped Pelvic Side: A Brief Report

Taşkın

Altın

Şükür

et al. 2018

Int J Gynecol Cancer

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“…This protocol provided a high detection rate (86.1% of overall detection rate and 73% of bilateral detection rate) consistent with other studies using this technique. Overall and bilateral SLN detection rates for ICG are reported between 86-100% and 52-88%, respectively [24][25][26][27][28][29][30][31]. This indicates that there is a short learning curve for the technique as SLNs were reliably detected in this early phase of introducing the ICG and NIFR SLN mapping protocol in our institution.…”

Section: Discussionmentioning

confidence: 70%

Retrospective review of sentinel lymph node mapping in endometrial cancer using indocyanine green and near infra-red fluorescence imaging during minimally invasive surgery

Chaowawanit¹,

Campbell²,

Wilson³

et al. 2021

European Journal of Gynaecological Oncology

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To determine the feasibility of sentinel lymph node (SLN) mapping in early-stage endometrial cancer and to evaluate the impact of the SLN result on adjuvant therapy prescription. Materials and methods: 140 women with histologically confirmed endometrial cancer, treated with a minimally invasive hysterectomy, bilateral salpingo-oophorectomy and SLN mapping were included. All mapped SLNs were confirmed by histopathology. Where the SLN was negative on H&E staining, ultra-staging with IHC was performed. Results: From January 2017 to May 2019, 122 patients were analysed. The overall and bilateral SLN detection rates were 86% (105/122) and 73% (89/122), respectively. The detection rates were not significantly different between low and high-risk disease. SLN metastasis was found in 15% (3/20) of patients the in high-risk group and 5.7% (5/87) in the low-risk group. Six of the 8 cases were identified by ultra-staging. Fourteen of 103 patients had their adjuvant treatment reduced based on SLN status after ultra-staging. Conclusion: SLN mapping can reliably detect the SLN in low and high-risk disease. The advantage for SLN mapping is in low-risk patients that allowed them to receive appropriate adjuvant therapy. Ultra-staging with IHC increased the detection of positive SLNs and decreased the prescribed adjuvant therapy in 14% of our patients.

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“…[35][36][37] NIRS is also widely used in bioassays or the determination of prostate-specific antigen 33 or in immunoassays. 38,39 Due to the advantages of NIRS, such as fast analysis speed, safety, non-destructive assessment of samples, and high accuracy, it can be used to identify benign tumors and cancers by examination of tissues, such as breast cancer, 40 endometrial cancer, 41 gastric cancer, 42 and CRC, 43 by combining NIRS with chemometrics. 44 In a previous study, our research group also found that the characteristic spectra obtained from CRC samples (formalin-fixed, paraffin-embedded) using NIRS could quickly distinguish CRC tissue from normal intestinal mucosa tissue.…”

Section: Introductionmentioning

confidence: 99%

Preliminary Study on the Identification of BRAFV600E Mutation in Colorectal Cancer by Near-Infrared Spectroscopy

Duan

Yang

Yin

et al. 2020

OTT

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Introduction In metastatic colorectal cancer (mCRC), the B-type Raf kinase (BRAF) V600E mutation is a molecular biomarker of poor prognosis and is of great importance to drug target. Currently, the commonly used methods for detecting BRAF V600E mutation include immunohistochemistry (IHC) and gene sequencing, but both present certain limitations. Near-infrared (NIR) spectroscopy is a spectroscopy technology that takes advantage of the electromagnetic wavelength between visible light and mid-infrared light. Methods IHC was used to detect the expression of BRAF V600E protein with the BRAF V600E (VE1) antibody in 42 cases of paraffin-embedded (FFPE) mCRC tissue sections. The NIR-discriminant analysis model (NIRS-DA) was established using 6 cases of wild-type and 6 cases of mutant-type BRAF specimens. Results IHC detection results revealed 13 cases of weakly positive (+), 1 case of moderately positive (++), and 28 cases of negative (−) CRC. Compared with the next-generation sequencing (NGS) results, the positive rate was 66.7%. The classification accuracy of calibration (CAC) was 100% compared with the results of NGS, demonstrating that the BRAF V600E mutant NIRS-DA model, verified by 2 cases of wild-type and 2 cases of mutant-type CRC samples was established. The NIRS-DA model was used to predict gene mutation in the CRC samples, 7 cases were positive (+), and 35 cases were negative (−), and the classification accuracy of prediction (CAP) was 83.3% (35/42). Discussion The NIRS-DA model-predicted results were in high agreement with the detection results of NGS, and the difference in IHC is not statistically significant (P>0.05). However, this study is a preliminary discussion on a methodology due to its small sample size.

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Laparoscopic near-infrared fluorescent imaging as an alternative option for sentinel lymph node mapping in endometrial cancer: A prospective study

Abstract: Sentinel lymph node mapping can easily be performed with high accuracy by using NIR/ICG integrated conventional laparoscopic system in endometrial cancer and almost all lymphatic spread can be detected.

Cited by 19 publications

References 17 publications

Extrapelvic Sentinel Lymph Nodes in Endometrial Cancer Patients With Unmapped Pelvic Side: A Brief Report

Extrapelvic Sentinel Lymph Nodes in Endometrial Cancer Patients With Unmapped Pelvic Side: A Brief Report

Retrospective review of sentinel lymph node mapping in endometrial cancer using indocyanine green and near infra-red fluorescence imaging during minimally invasive surgery

Preliminary Study on the Identification of BRAFV600E Mutation in Colorectal Cancer by Near-Infrared Spectroscopy

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