Laparoscopic Mid Sagittal Hemicystectomy and Bladder Reconstruction With Small Intestinal Submucosa and Reimplantation of Ureter Into Small Intestinal Submucosa: 1-Year Followup

Landman, Jaime; Olweny, Ephrem O.; Sundaram, Chandru P.; Andreoni, Cássio; Collyer, William C.; Rehman, Jamil; Jerde, Travis J.; Lin, Hsueh Kung; Lee, David I.; Nunlist, Eva; Humphrey, Peter A.; Nakada, S.Y.; Clayman, Ralph V.

doi:10.1097/01.ju.0000127756.64619.27

Cited by 44 publications

(15 citation statements)

References 16 publications

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“…Nerves were present at the graft periphery and center but they were decreased in number. Compared to primary bladder closure after hemi-cystectomy, no advantage in bladder capacity or compliance was documented [81]. More recently, bladder regeneration has been shown to be more reliable when the SIS was derived from the distal ileum [82].…”

Section: Tissue Engineering Strategies For Bladder Augmentation and Rmentioning

confidence: 99%

Regenerative Medicine Strategies for Treating Neurogenic Bladder

et al. 2011

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Neurogenic bladder is a general term encompassing various neurologic dysfunctions of the bladder and the external urethral sphincter. These can be caused by damage or disease. Therapeutic management options can be conservative, minimally invasive, or surgical. The current standard for surgical management is bladder augmentation using intestinal segments. However, because intestinal tissue possesses different functional characteristics than bladder tissue, numerous complications can ensue, including excess mucus production, urinary stone formation, and malignancy. As a result, investigators have sought after alternative solutions. Tissue engineering is a scientific field that uses combinations of cells and biomaterials to encourage regeneration of new, healthy tissue and offers an alternative approach for the replacement of lost or deficient organs, including the bladder. Promising results using tissue-engineered bladder have already been obtained in children with neurogenic bladder caused by myelomeningocele. Human clinical trials, governed by the Food and Drug Administration, are ongoing in the United States in both children and adults to further evaluate the safety and efficacy of this technology. This review will introduce the principles of tissue engineering and discuss how it can be used to treat refractory cases of neurogenic bladder.

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Section: Tissue Engineering Strategies For Bladder Augmentation and Rmentioning

confidence: 99%

Regenerative Medicine Strategies for Treating Neurogenic Bladder

et al. 2011

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“…Often the grafts contracted to 60%-70% of their original size with little increase in bladder capacity or compliance (43,44). Studies involving acellular matrices that may provide the necessary environment to promote cell migration, growth, and differentiation are being conducted.…”

Section: Bladdermentioning

confidence: 99%

Bioengineered Tissues for Urogenital Repair in Children

Atala

2008

Pediatr Res

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“…Furthermore, the material should be biodegradable to support the replacement by normal tissue. Several attempts have been made to identify such an ideal scaffold, such as decellularized matrices (bladder submucosa or small intestine submucosa) [3][4][5][6], collagen-based [7][8][9], and synthetic materials [10,11]. Natural materials are of significant interest due to the biocompatibility of the substrates themselves and their degradation products.…”

Section: Introductionmentioning

confidence: 99%

Microstructure and cytocompatibility of collagen matrices for urological tissue engineering

et al. 2010

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RESULTS• The best cytocompatibility for both urinary tract-specific cell types was obtained with OptiMaix® (Matricel GmbH, Herzogenrath, Germany) materials.• Cell-specific phenotypes were maintained during culture as shown by immunohistochemical staining.• Furthermore, simultaneous cultivation of both cell types for 7 and 14 days significantly reduced urea permeability. CONCLUSION• These results show the potential of OptiMaix materials in tissue engineering approaches of urinary tract tissues.

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Laparoscopic Mid Sagittal Hemicystectomy and Bladder Reconstruction With Small Intestinal Submucosa and Reimplantation of Ureter Into Small Intestinal Submucosa: 1-Year Followup

Abstract: Laparoscopic SIS bladder reconstruction and ureteral reimplantation into the SIS after hemicystectomy are technically feasible. However, compared to primary bladder closure no advantage in bladder capacity or compliance was documented.

Cited by 44 publications

References 16 publications

Regenerative Medicine Strategies for Treating Neurogenic Bladder

Regenerative Medicine Strategies for Treating Neurogenic Bladder

Bioengineered Tissues for Urogenital Repair in Children

Microstructure and cytocompatibility of collagen matrices for urological tissue engineering

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