Laparoscopic high lateral transposition of both ovaries before pelvic irradiation

Yaralı́, Hakan; Bükülmez, Orhan; Çoşkun, Fehmi; Gürgan, Timur

doi:10.1016/s1074-3804(00)80047-x

Cited by 20 publications

(7 citation statements)

References 7 publications

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“…Ovarian transposition should be performed laparoscopically prior to the initiation of radiotherapy. An important advantage of laparoscopic ovarian transposition is that radiotherapy can be initiated immediately postoperatively, preventing failure due to the ovaries migrating back to the radiation field [56]. The outpatient nature of the procedure, with more rapid recovery, less discomfort, better cosmetic result and lower cost, are additional advantages to the laparoscopic approach.…”

Section: Ovarian Transpositionmentioning

confidence: 99%

Fertility Preservation in Cancer Patients

Falcone

2006

Womens Health (Lond Engl)

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Fertility preservation is an important but often neglected need of cancer patients. There are several options available but many are considered experimental or are unproven. Most require interventions that can postpone the initiation of cancer treatment. The options include surgical procedures to move the ovaries out of the path of a radiation field, prophylactic medical therapy with gonadotropin-releasing hormone agonists and storage of gametes, embryos or gonadal tissue. Embryo freezing after conventional in vitro fertilization has a high success rate. Experimental fertility preservation procedures such as oocyte freezing and ovarian tissue cryopreservation/transplantation should be offered to cancer patients only under institutional review board oversight. Laparoscopic ovarian transposition is a viable option if radiotherapy is to be used alone. Oncologists, reproductive endocrinologists and other healthcare professionals should be part of a multidisciplinary team that offers cancer patients options to preserve their reproductive potential if they desire to do so.

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Section: Ovarian Transpositionmentioning

confidence: 99%

Fertility Preservation in Cancer Patients

Falcone

2006

Womens Health (Lond Engl)

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“…Transposition of the ovaries before radiotherapy can reduce the dose to approximately 10% of the given dose during pelvic radiotherapy [48,76,77]. This practice has been shown to reduce the incidence of ovarian dysfunction [77][78][79]. However, routine use of ovarian transposition in Hodgkin's disease patients treated with radiotherapy remains controversial.…”

Section: Prevention Of Ovarian Failurementioning

confidence: 99%

Fertility preservation and management of gonadal failure associated with lymphoma therapy

Howell¹,

Shalet

2002

Curr Oncol Rep

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Treatment with cytotoxic chemotherapy and radiotherapy is associated with significant gonadal damage in men and women. The likelihood of gonadal failure following cytotoxic chemotherapy is dependent on the drug and dose, and in women there is also an effect of age at treatment. Irradiation of the testes or ovaries, either directly or indirectly, is also a significant cause of gonadal dysfunction, and the potential to recover from damage is clearly related to the radiation dose received. Several methods of preserving gonadal function during potentially sterilizing treatment have been considered. At present, sperm banking remains the only proven method in men, although hormonal manipulation to enhance recovery of spermatogenesis and cryopreservation of testicular germ cells are possibilities for the future. Transposition of the ovaries to allow better shielding during radiotherapy is of use in some women, and the prospect of cryopreservation and reimplanation of ovarian tissue appears to be promising.

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“…Contemporary procedures transpose the ovaries above the pelvic brim and as lateral as possible, which minimizes the ovarian dose of radiation and improves efficacy compared with medial approaches. Various lateral locations have been used: the base of the round ligament (9), the level of lower kidney pole (10), and the paracolic gutters (first introduced by Larue-Chalus S. in 1987) (6,11,12). Historically, exploratory laparatomy performed for staging or debulking procedures for these malignancies provided an opportunity to perform ovarian transposition.…”

Section: Introductionmentioning

confidence: 99%

Laparoscopic ovarian transposition in patients with pelvic cancer

Žilinskas¹,

Sabonytė-Balšaitienė²,

Samalavičius³

2014

AML

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Background. The aim of this study was to evaluate the feasibility of laparoscopic ovarian transposition prior to radiation therapy on the preservation of hormonal function in the treatment of pelvic cancer. Materials and methods. A chart review of premenopausal women diag nosed with pelvic cancer, who underwent laparoscopic ovarian transposition to paracolic gutters, then received preoperative radiotherapy at the Center of Oncosurgery, Oncology Institute of Vilnius, from January 2010 to July 2013. Results. A total of 14 patients underwent laparoscopic ovarian transposition. Patients were divided into two groups by localisation of can cer: 2 (14.29%) patients diagnosed with rectal cancer and 12 (85.71%) with cervical cancer. Patients' age was from 24 to 42 years with a mean age of 33.71 (SD ± 5.22) years. The average age of the patients in the first group was 26 (SD ± 2.83) years. In the second group women, aged 29 and 42 years with a mean age of 35 (SD ± 4.35) years, were analyzed. Rectal cancer of stage III was diagnosed in both women of the first group. Tumor stage distribution in the second group, respectively: stage I-2 cases (16.67%), stage II-3 cases (25%), stage III-7 cases (58.33%). Seven (58.33%) patients of the second group underwent complete endoscopic staging. In these groups of 14 patients there were 2 (14.3%) complications (injury of the inferior vena cava and postoperative abnormal vaginal bleeding). No postoperative exitus occurred. The mean duration of the operation was 2 hours 26 minutes ± 55 minutes (60-245 minutes), respectively, 2 hours 40 minutes ± 49 minutes (95-245 minutes) when laparoscopic staging and ovarian transposition was performed and 2 hours 12 minutes ± 1 hour 1 minute (60-245 minutes) when only ovarian transposition was performed. The hospitalization period ranged from 5 to 52 days (average 12 days). Conclusions. Laparoscopic ovarian transposition is a relatively safe and effective procedure for preserving ovarian function. This procedure should be considered in all reproductive age female patients who need to undergo pelvic irradiation as part of pelvic cancer treatment.

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Laparoscopic high lateral transposition of both ovaries before pelvic irradiation

Cited by 20 publications

References 7 publications

Fertility Preservation in Cancer Patients

Fertility Preservation in Cancer Patients

Fertility preservation and management of gonadal failure associated with lymphoma therapy

Laparoscopic ovarian transposition in patients with pelvic cancer

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