Laparoscopic Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in Patients with Limited Peritoneal Surface Malignancies

Esquivel, Jesús; Averbach, Andrew; Chua, Terence C.

doi:10.1097/sla.0b013e31820784df

Cited by 75 publications

(40 citation statements)

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“…Similar to our effort to improve HIPEC, many surgeons have tried to improve CRS, which has low morbidity and high survival rates [18]. Shin et al reported feasibility of complete mesocolic excision with D3 lymph node dissection in laparoscopic colectomy [19].…”

Section: Discussionmentioning

confidence: 99%

Feasibility of hyperthermic pressurized intraperitoneal aerosol chemotherapy in a porcine model

Jung

Son

et al. 2015

Surg Endosc

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Section: Discussionmentioning

confidence: 99%

Feasibility of hyperthermic pressurized intraperitoneal aerosol chemotherapy in a porcine model

Jung

Son

et al. 2015

Surg Endosc

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“…Some centres have also performed curative intent laparoscopic CRS/HIPEC in selected patients with limited PC. Esquivel et al concluded that the laparoscopic procedure was feasible and safe in patients with an appendiceal malignancy, a low tumour volume and no small bowel involvement [56]. A longer follow-up period would be beneficial to evaluate its long-term efficacy.…”

Section: Perfusion Techniquesmentioning

confidence: 99%

Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Methodology, Drugs and Bidirectional Chemotherapy

Valle

Alzahrani

Sugarbaker

et al. 2016

Indian J Surg Oncol

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Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) combined have been recognized as standard of care for treatment of a subset of patients with peritoneal carcinomatosis (PC). The aim of CRS is to eliminate all macroscopic disease through a series of visceral resections followed by targeting any residual microscopic disease with intraperitoneal chemotherapy, exposing the peritoneal surfaces to a high concentration of chemotherapy with a lower systemic toxicity. Different regimes of intraperitoneal chemotherapy include HIPEC, early postoperative intraperitoneal chemotherapy (EPIC) and bidirectional chemotherapy. The efficacy and modality of treatment with intraperitoneal chemotherapy is dependent on multiple factors including the chosen cytotoxic agent and its pharmacokinetics and pharmacodynamics. There is no standardized methodology for intraperitoneal chemotherapy administration. This review will discuss the pharmacological principles of the various intraperitoneal chemotherapy techniques.

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“…Peritoneal cancer index (PCI) can help to select patients who will benefit from laparoscopic-CRS and HIPEC. A PCI <10 in CT scan before surgery or during laparoscopic surgery may indicate that laparoscopic CRS and HIPEC surgery may be feasible and safe by this approach [14][15][16]. In case of local peritoneal metastases recurrence, minimally invasive surgery þ HIPEC laparoscopy has shown to be a safe procedure in ovarian cancer (less surgical time, less blood losses and shorter hospital stay than open surgery).…”

Section: Discussionmentioning

confidence: 99%

Hyperthermic chemotherapy intra-abdominal laparoscopic approach: development of a laparoscopic model using CO₂ recirculation system and clinical translation in peritoneal carcinomatosis

Sánchez-García

Padilla

Campos

et al. 2017

International Journal of Hyperthermia

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Hyperthermic chemotherapy intra-abdominal laparoscopic approach: development of a laparoscopic model using CO 2 recirculation system and clinical translation in peritoneal carcinomatosis Susana S anchez-Garc ıa, David Padilla-Valverde, Pedro Villarejo-Campos, Esther P. Garc ıa-Santos and Jes us Mart ın-Fern andez Department of General Surgery, University General Hospital, Medicine School, University of Castilla la Mancha, Ciudad Real, Spain ABSTRACT Introduction: Hyperthermic intraperitoneal chemotherapy (HIPEC) is an effective treatment for peritoneal carcinomatosis (PC). Laparoscopic surgery is performed in the treatment of colorectal and appendiceal cancer, and PC from diverse origin in selected patients. HIPEC management by laparoscopic approach after cytoreductive surgery (CRS) completed locoregional treatment of PC, and may be feasible and safe after appropriate patient selection. Objective: Development of an experimental model of HIPEC by laparoscopic approach, with CO 2 recirculation. Clinical translation in two patients with PC and low peritoneal cancer index. Material and methods: We performed CRS in a porcine model of 5 pigs (35-38 kg) by laparoscopic approach. Laparoscopic HIPEC by CO 2 recirculation system was performed; laparoscopic access was used for catheter input and output placement (Paclitaxel 175 mg/m 2 for 60 min at 42 C). The experimental variables were: blood gases, haemodynamic and intra-abdominal and central temperature. Clinical model application was performed in three cases with PC from colorectal origin. Results: No statistically significant differences was found in blood gases, haemodynamic or temperature in the experimental study. In clinical study, there were no technical complications during laparoscopic-HIPEC approach, and we observed no changes in haemodynamic variables during the procedure. Conclusions: CRS and HIPEC laparoscopic model by CO 2 recirculation system is safe and feasible technique in selected patients, that include low PC index, local and accessible tumour recurrences or high-risk of PC tumours.

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Laparoscopic Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in Patients with Limited Peritoneal Surface Malignancies

Cited by 75 publications

References 0 publications

Feasibility of hyperthermic pressurized intraperitoneal aerosol chemotherapy in a porcine model

Feasibility of hyperthermic pressurized intraperitoneal aerosol chemotherapy in a porcine model

Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Methodology, Drugs and Bidirectional Chemotherapy

Hyperthermic chemotherapy intra-abdominal laparoscopic approach: development of a laparoscopic model using CO₂ recirculation system and clinical translation in peritoneal carcinomatosis

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Laparoscopic Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in Patients with Limited Peritoneal Surface Malignancies

Cited by 75 publications

References 0 publications

Feasibility of hyperthermic pressurized intraperitoneal aerosol chemotherapy in a porcine model

Feasibility of hyperthermic pressurized intraperitoneal aerosol chemotherapy in a porcine model

Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Methodology, Drugs and Bidirectional Chemotherapy

Hyperthermic chemotherapy intra-abdominal laparoscopic approach: development of a laparoscopic model using CO2 recirculation system and clinical translation in peritoneal carcinomatosis

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Hyperthermic chemotherapy intra-abdominal laparoscopic approach: development of a laparoscopic model using CO₂ recirculation system and clinical translation in peritoneal carcinomatosis