Background
Quantitative computed tomography (CT) assessment of visceral
adiposity may be superior to body mass index (BMI) as a predictor of
surgical morbidity. We sought to examine the association of CT measures of
obesity and BMI with short-term post-operative outcomes in colon cancer
patients.
Methods
In this retrospective study, 110 patients treated with colectomy for
Stage I–III colon cancer were classified as obese or non-obese by
pre-operative CT-based measures of adiposity or BMI. [Obese:
BMI≥30kg/m2, visceral fat area (VFA) to subcutaneous
fat area ratio (V/S) ≥0.4 and
VFA>100cm2)]. Post-operative morbidity and
mortality rates were compared.
Results
Obese patients, by V/S and VFA but not BMI, were more likely to be
male and have pre-existing hypertension and diabetes. The overall
complication rate was 25.5% and there were no mortalities. Obese
patients by VFA (with a trend for VS but not BMI) were more likely to
develop postoperative complications as compared to patients classified as
non-obese; VFA (30.5% vs.10.7%, p=
0.03), VS (29.2% vs. 9.5%, p=0.05)
and BMI (32.4% vs. 21.9%,
p=0.23).
Conclusions
Elevated visceral obesity quantified by CT is associated with the
presence of key metabolic comorbidities and increased post-operative
morbidity and may be superior to BMI for risk stratification.