Laparoscopic cholecystectomy in adults with sickle cell disease

Abstract

LC has proven to be a safe and efficacious method for the treatment of symptomatic cholelithiasis in this high-risk population. Hematologists are now more willing to refer early, well-prepared patients with SCD and uncomplicated gallbladder disease for elective LC.

Laparoscopic cholecystectomy in 427 adults with sickle cell disease: a single-center experience

“…In our setting, 8% of LCs was performed in patients with SCD. This figure is markedly higher than 0.31% reported in Greece by Bonatsos et al [10]. This difference may reflect variation in the epidemiology of SCD and gallstones, and the patients studied.…”

“…Hence, we believe that prophylactic cholecystectomy for sicklers with asymptomatic gallstones is unwarranted. However, we agree with those who advocate early elective cholecystectomy for sicklers with symptomatic gallstones to prevent serious complications [4,10]. In addition, cholecystectomy simplifies the management of acute abdomen in these patients.…”

“…Hence, most surgeons advocate LC in these patients [6,[8][9][10][11][12]14]. Yet, two reports have documented an increased incidence of ACS after LC in patients with SCD [13,15].…”

“…These benefits are very important for patients with SCD, who are immunocompromised and at a higher risk to develop postoperative infection. To date, only small series of LC in adults with SCD have been reported [8][9][10][11][12][13][14][15]. We report our experience with a large series of LCs in adults with SCD.…”

Laparoscopic Cholecystectomy Results In Patients With Different Age Groups

“…Especially diseases with hemolytic result in enlarged bilirubin pool, crystallization and stone formation. Hematologi-cal disorder such as sickle cell anemia has a high incidence of cholelithiasis [19,20]. The majority of patients in this study underwent LC for symptomatic cholelithiasis.…”