Lanthony 15-Hue Desaturated Test for Screening of Early Color Vision Defects in Uncomplicated Juvenile Diabetes

Giusti, C

doi:10.1016/s0021-5155(01)00413-0

Cited by 20 publications

(15 citation statements)

References 20 publications

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“…Some previous studies also report significant color vision defects in type 1 diabetes (24,25). However, these studies did not provide a clear cutoff between prevascular and vascular stages.…”

Section: Discussionmentioning

confidence: 76%

“…This is possible in the pre-DR stage (14)(15)(16)(17). Some functional studies have suggested visual impairment in diabetic patients without apparent DR, but these studies did not exclude changes in integrity of the barrier function using a quantitative method (2,(18)(19)(20)(21)(22)(23)(24)(25). The occurrence of structural changes indicating vascular damage is also quite disputed in type 1 diabetic patients at a preclinical stage (23,26), possibly because the way patients are phenotyped may vary across studies.…”

mentioning

confidence: 99%

“…A link of such deficits with parvo-and magnocellular impairment is, however, missing. Besides the changes in achromatic contrast sensitivity (20,22), there are also studies showing changed psychophysical and physiologic changes in these patients without DR, related to color contrast sensitivity (24,25) and multifocal electroretinogram (mfERG) responses (21). It remains unclear whether these changes can be present independently of vascular damage (e.g., if they could reflect direct neural damage).…”

mentioning

confidence: 99%

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Neuroretinal Dysfunction With Intact Blood-Retinal Barrier and Absent Vasculopathy in Type 1 Diabetes

et al. 2014

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It is unknown whether independent neural damage may occur in the pre-/absent vascular diabetic retinopathy (DR). To exclude vasculopathy, it is important to measure the integrity of the blood-retinal barrier (BRB). This cross-sectional study addressed this problem in type 1 diabetic patients with normal ocular fundus and absent breakdown of the BRB (confirmed with vitreous fluorometry). These were compared with a group with disrupted BRB (with normal fundus or initial DR) and normal controls. Multifocal electroretinography and chromatic/achromatic contrast sensitivity were measured in these 42 patients with preserved visual acuity. Amplitudes of neurophysiological responses (multifocal electroretinogram) were decreased in all eccentricity rings in both clinical groups, when compared with controls, with sensitivity >78% for a specificity level of 90%. Implicit time changes were also found in the absence of initial DR. Impaired contrast sensitivity along chromatic axes was also observed, and achromatic thresholds were also different between controls and both clinical groups. The pattern of changes in the group without baseline BRB permeability alterations, as probed by psychophysical and electrophysiological measurements, does thereby confirm independent damage mechanisms. We conclude that retinal neuronal changes can be diagnosed in type 1 diabetes, independently of the breakdown of the BRB and onset of vasculopathy.

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Section: Discussionmentioning

confidence: 76%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Neuroretinal Dysfunction With Intact Blood-Retinal Barrier and Absent Vasculopathy in Type 1 Diabetes

et al. 2014

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Section: Discussionmentioning

confidence: 99%

“…We chose these two color vision tests because they are rather short, so relatively easy for children, and L15 was found to be the most suitable test for screening of early color vision abnormalities in uncomplicated juvenile diabetes [33]. It is only the Fansworth-Munsell 100-Hue test that has the same clinical reliability and sensitivity, but its results are affected-particularly in children-by the much longer execution time [33,34]. The increased prevalence of impaired color vision, reported earlier in the CRYO-ROP study with the Standard Pseudoisochromatic Plates (SPP) in a big population [10], was not detected in several smaller studies with psychophysical methods [5][6][7][8][9].…”

Section: Discussionmentioning

confidence: 99%

Cone function in children with a history of preterm birth

et al. 2011

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Color vision was examined by psychophysical tests and photopic color full-field electroretinography (ERG) in formerly preterm children, and compared with those of full-term children. In a prospective case-control study, 25 patients with a history of preterm birth 7-14 years of age were divided into three groups: group I, laser-treated retinopathy of prematurity [ROP] (n = 7); group II, spontaneously regressed ROP (n = 8); group III, no ROP (n = 10). Age-matched full-term born children comprised the control group (n = 8). Color vision was assessed by Fansworth D15 and Lanthony desaturated D15 tests. The cone function was tested using photopic full-field ERG. Besides the ISCEV standard stimuli, blue light on amber background was also used (S-cone ERG). The correlation between ERG parameters and prematurity or ROP was determined. We found no significant differences between any patient group and the control group in the results of the psychophysical tests, and implicit times of the ERG responses. The ERG b-wave amplitudes were significantly lower in group I (laser-treated ROP) compared to controls, for 2 of 4 stimulus conditions i.e. the standard (P = 0.028) and S-cone (P = 0.017) single flash ERGs. The general estimating equation model statistics found a significant effect of prematurity on the b-wave amplitudes (P = 0.025, standard, P = 0.014, S-cone ERG). A slightly reduced photopic ERG b-wave amplitude may be associated with prematurity.

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Visual Psychophysics in Diabetic Retinopathy

Midena

Vujosevic

2011

Visual Dysfunction in Diabetes

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Lanthony 15-Hue Desaturated Test for Screening of Early Color Vision Defects in Uncomplicated Juvenile Diabetes

Cited by 20 publications

References 20 publications

Neuroretinal Dysfunction With Intact Blood-Retinal Barrier and Absent Vasculopathy in Type 1 Diabetes

Neuroretinal Dysfunction With Intact Blood-Retinal Barrier and Absent Vasculopathy in Type 1 Diabetes

Cone function in children with a history of preterm birth

Visual Psychophysics in Diabetic Retinopathy

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