Lanthanides: Schiff base complexes, applications in cancer diagnosis, therapy, and antibacterial activity

Kaczmarek, Małgorzata T.; Zabiszak, Michał; Nowak, Martyna

doi:10.1016/j.ccr.2018.05.012

Cited by 255 publications

(112 citation statements)

References 112 publications

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“…In addition, most of Schiff bases have the fascinating abilities to coordinate with metallic ions to form their corresponding complexes of main group, transition metal and lanthanide and actinides elements, with their properties being significantly improved by coordinating to the metal ion [38][39][40]. This ability is due to their stereoelectronic and flexible structures leading to highly versatile coordination compounds with a broad scope of applications rranging from subterranean fluid flow tracking [41,42] to bioinorganic and medicinal chemistry [43,44]. For instance, in the rational design of metal-based therapeutics, Meade and co-workers developed a serries of N-heterocyclic cobalt(III) Schiff base Complexes as potent enzyme and transcription factor inhibitors [45].…”

Section: Figmentioning

confidence: 99%

Recent developments in penta-, hexa- and heptadentate Schiff base ligands and their metal complexes

Liu

Hamon

2019

Coordination Chemistry Reviews

307

137

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Novel ligand platforms that promote reactivity are of long standing and continued interest in coordination chemistry, with Schiff base ligands and their metal complexes representing one of the most versatile and long standing topics of interest. The synthesis and structure of polydentate Schiff bases and their metal complexes is fascinating, because it reveals a great richness of structural, physico-chemical and catalytic properties. Given the simplicity and ease of access to multidentate Schiff bases and their metal complexes, investigation of such compounds is essential to precise and understand structure-property relationships in order to optimize and improve their use in a wide range of fields, including catalysis, supramolecular chemistry, magnetism, electrochemistry, nanoscience, energy materials, and biological applications. This review highlights the recent developments of pentadentate, hexadentate, heptadentate and macrocyclic Schiff base ligands containing various donor sets made of different combinations of N, O, S or P donor atoms and their metal complexes (essentially mononuclear), as well as presenting synthetic methods and interesting structures of complexes formed by first-to-third row transition metals (from group 4-12), main group elements, lanthanides and actinides. This review is divided into three main sections, each of them corresponding to one type of denticity of the Schiff base under consideration. Each category is described with representative examples according to a periodic order, and emphasis is given to the coordination aspects. Their catalytic, magnetic and biological properties are also outlined. This review that contains 359 references should act as a source of information to researchers interested to work in this domain and stimulate further investigation in this fascinating area of Schiff base coordination compounds.

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Section: Figmentioning

confidence: 99%

Recent developments in penta-, hexa- and heptadentate Schiff base ligands and their metal complexes

Liu

Hamon

2019

Coordination Chemistry Reviews

307

137

View full text Add to dashboard Cite

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“…Analogous properties of lanthanide (III) and calcium ions are also interesting from the point of medicinal chemistry. Lanthanide complexes based on Schiff base ligands were found to be useful in cancer diagnosis and therapy, and for their antibacterial activity . Most Schiff base ligands are easy to prepare, and they can be incorporated in complexes together with the lanthanide ions using usual synthetic procedures.…”

Section: Introductionmentioning

confidence: 99%

Binuclear Lanthanide(III) Complexes with Chiral Ligands: Dynamic Equilibria in Solution and Binding with Nucleotides Studied by Spectroscopic Methods

Sahoo

Klepetářová

et al. 2020

ChemPlusChem

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Binuclear lanthanide complexes of Eu(III) and Sm(III) were obtained in the presence of chiral ligand 1,2‐(R,R+S,S)‐N,N’‐bis(2‐pyridylmethylene),2‐diamine. An unusual structure of the Eu(III) compound with two lanthanide atoms connected through two chlorines was determined by X‐ray crystallography. In solution, the dimer coexists with a monomeric complex, and the stability of the binuclear form depends on the solvent and concentration. The dimer‐monomer equilibrium was monitored by circularly polarized luminescence (CPL) measured on a Raman optical activity (ROA) spectrometer, where both forms provided large CPL anisotropic ratios of up to 5.6×10−2. Monomer formation was favored in water, whereas the dimer was stabilized in methanol. When mixed with adenosine phosphates, AMP gave much smaller CPL than ADP and ATP, indicating a high affinity of the Eu (III) complex for the phosphate group, which in connection with the ROA/CPL technique can be developed into a bioanalytical probe.

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“…Emission of lanthanide(III) ions, e.g., Nd(III), Sm(III), or Yb(III) in the Near-infrared (NIR) region that is detected through animal tissue of considerable thickness, could also be used for imaging in vivo [4]. Additionally, lanthanide(III) compounds are used as antibacterial agents [5][6][7][8] and show very effective catalytic properties with high selectivity for hydrolytic cleavage or transesterification of RNA and as a substance promoting DNA cleavage [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Thermodynamic and Spectroscopic Studies of the Complexes Formed in Tartaric Acid and Lanthanide(III) Ions Binary Systems

et al. 2020

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Binary complexes of tartaric acid with lanthanide(III) ions were investigated. The studies have been performed in aqueous solution using the potentiometric method with computer analysis of the data for detection of the complexes set, determination of the stability constants of these compounds. The mode of the coordination of complexes found was determined using spectroscopy, which shows: Infrared, circular dichroism, ultraviolet, visible as well as luminescence spectroscopy. The overall stability constants of the complexes as well as the equilibrium constants of the reaction were determined. Analysis of the equilibrium constants of the reactions and spectroscopic data allowed the effectiveness of the carboxyl groups in the process of complex formation.

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Lanthanides: Schiff base complexes, applications in cancer diagnosis, therapy, and antibacterial activity

Cited by 255 publications

References 112 publications

Recent developments in penta-, hexa- and heptadentate Schiff base ligands and their metal complexes

Recent developments in penta-, hexa- and heptadentate Schiff base ligands and their metal complexes

Binuclear Lanthanide(III) Complexes with Chiral Ligands: Dynamic Equilibria in Solution and Binding with Nucleotides Studied by Spectroscopic Methods

Thermodynamic and Spectroscopic Studies of the Complexes Formed in Tartaric Acid and Lanthanide(III) Ions Binary Systems

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