Lanthanide (Gd3+ and Yb3+) functionalized gold nanoparticles for in vivo imaging and therapy

Sun

et al. 2020

Adv Funct Materials

105

Gold‐based nanostructures with tunable wavelength of localized surface plasmon resonance (LSPR) in the second near‐infrared (NIR‐II) biowindow receive increasing attention in phototheranostics. In view of limited progress on NIR‐II gold nanostructures, a particular liposome template‐guided route is explored to synthesize novel gold nanoframeworks (AuNFs) with large mesopores (≈40 nm) for multimodal imaging along with therapeutic robustness. The synthesized AuNFs exhibit strong absorbance in NIR‐II region, affording their capacity of NIR‐II photothermal therapy (PTT) and photoacoustic (PA) imaging for deep tumors. Functionalization of AuNFs with hyaluronic acid (HA) endows the targeting capacity for CD44‐overexpressed tumor cells while gatekeeping doxorubicin (DOX) loaded into mesopores. Conjugation of Raman reporter 4‐aminothiophenol (4‐ATP) onto AuNFs yields a surface‐enhanced Raman scattering (SERS) fingerprint for Raman spectroscopy/imaging. In vivo evaluation of HA‐4‐ATP‐AuNFs‐DOX on tumor‐bearing xenografts demonstrates its high efficacy in eradication of solid tumors in NIR‐II under PA–Raman dual image‐guided photo‐chemotherapy. Thus, current AuNFs offer versatile capabilities for phototheranostics.

Section: Introductionmentioning

confidence: 99%

Gold Nanoframeworks with Mesopores for Raman–Photoacoustic Imaging and Photo‐Chemo Tumor Therapy in the Second Near‐Infrared Biowindow

Sun

et al. 2020

Adv Funct Materials

105

Artificial Cells, Nanomedicine, and Biotechnology

“…The disadvantage is that the surface modification method is not rich, the cost is high, and the biological safety of nanogold is still questioned. In recent years, based on the superior performance of nanogold as a nanodrug carrier, the development of nanogold surface modification methods, and the design and preparation of highly efficient tumor diagnosis and treatment reagents have become research hotspots [21][22][23][24][25][26][27][28].…”

Section: Nanogoldmentioning

confidence: 99%

“…Although the combination of multiple models has a significant effect on tumor treatment, complex nanodrug design is still difficult to apply to clinical treatment of tumors. In 2016, Ge et al [25] reported a case of Au@Se-R/A NCs, nanomedicines with nanorods as the nuclei for radiotherapy. As shown in Figure 5, by using nanorods as the nucleus and selenium as the shell design strategy, the target polypeptides RGD, ACPP and the fluorescent dye Coumarin-6 were introduced to achieve rapid enrichment of nanomedicines at the tumor site, and Coumarin fluorescence rapidly identifies tumor lesions.…”

Section: Nanogoldmentioning

confidence: 99%

Research progress of novel inorganic nanometre materials carriers in nanomedicine for cancer diagnosis and treatment

Liao

Jiang

et al. 2018

Nanomedicine, as the new achievement in combination of nanotechnology and medical science, has the potential to accurately monitor tumor for early diagnosis and dramatically improve the targeted, long-lasting and combinational therapy. Compared with traditional chemotheraphy, nanomedicine would effectively improve the drug accumulation and controlled release in the tumor sites to improve the therapeutic effect. Recently, all kinds of nanomedicines are designed and synthesized for tumor diagnosis and treatment based on inorganic nanocarriers, such as quantum dots, gold nanoparticles, silicon nanoparticles and so on. They might be adjusted and promoted their properties by core-shell structure, surface modification and other strategies. In this review, the inorganic nanometre materials as nanodrug carriers applied in tumor diagnosis and treatment were summarized; nanodrug carriers design strategies and mechanisms of tumor diagnosis and treatment were introduced in detail, the future and several questions still need to resolve about inorganic nanodrugs in tumor diagnosis and treatment of clinical application was prospected.

“…More recently, Ge et al prepared lanthanide functionalized gold nanoparticles for in vivo imaging and therapy. The nanoparticles were successfully applied to MRI, computed tomography and photothermal therapy for tumor-bearing mice in vivo [86]. Furthermore, hybrid inorganic-organic nanoplatforms have also been introduced for cancer therapy.…”

Section: Inorganic Nanoparticle-based Cancer Therapymentioning

confidence: 99%

Recent Advances on Inorganic Nanoparticle-Based Cancer Therapeutic Agents

Cheng

et al. 2016

IJERPH

109

Inorganic nanoparticles have been widely investigated as therapeutic agents for cancer treatments in biomedical fields due to their unique physical/chemical properties, versatile synthetic strategies, easy surface functionalization and excellent biocompatibility. This review focuses on the discussion of several types of inorganic nanoparticle-based cancer therapeutic agents, including gold nanoparticles, magnetic nanoparticles, upconversion nanoparticles and mesoporous silica nanoparticles. Several cancer therapy techniques are briefly introduced at the beginning. Emphasis is placed on how these inorganic nanoparticles can provide enhanced therapeutic efficacy in cancer treatment through site-specific accumulation, targeted drug delivery and stimulated drug release, with elaborations on several examples to highlight the respective strategies adopted. Finally, a brief summary and future challenges are included.