Lanthanide Complexes for Tumor Diagnosis and Therapy by Targeting Sialic Acid

Abstract

Sialic acid (SA) is overexpressed on cell membranes of tumor cells, and increased serum SA concentration has been observed in tumor-bearing patients. Herein, a series of lanthanide-containing bimetallic complexes (TDA–M–Lns) for targeting SA were prepared via coordination among luminescent lanthanide ions (Ln3+ = Tb3+, Eu3+, Dy3+, or Sm3+), metal ion quenchers (M2+ = Cu2+ or Co2+), and the organic ligand 2,2′-thiodiacetic acid (TDA). SA can competitively coordinate with Ln3+, resulting in the “signal-on” of the Ln3+. Therefore, the TDA–M–Lns can be simply used for cost-saving detection of SA in the blood samples. Among the TDA–M–Lns, TDA–Co–Eu showed the highest sensitivity to detect SA in the blood of tumor-bearing mice. Furthermore, the TDA–Co–Eu was successfully used to target SA and deposit Eu3+ on the surfaces of tumor cells for the inhibition of tumor cell growth and migration. The therapeutic effect of TDA–Co–Eu on a Balb/c mouse liver tumor model was evaluated. It was proved that TDA–Co–Eu can be applied for SA detection as well as for inhibiting tumor growth.

Lanthanide Metal–Organic Framework Isomers with Novel Water-Boosting Lanthanide Luminescence Behaviors

“…Metal–organic frameworks (MOFs) have emerged as highly ordered porous crystal materials, composed of organic ligands and metal centers. , The introduction of organic chromophores and metal ions endowed MOFs with abundant and interesting photophysical properties. By virtue of the high specific surface area, controllable pore size, tunable structure, and multiple coordination sites, MOFs presented extensive applications in many fields, such as chemical adsorption and separation, , chemical sensing, − drug delivery, , and heterogeneous catalysis. , Remarkably, lanthanide-based MOFs (Ln-MOFs) were constructed with Ln 3+ ions as metal centers, which manifested high and flexible coordination number and connectivity and possessed fascinating luminescence properties, including large Stokes shifts, long fluorescence lifetime, linear emission, high color purity, and a wide emission range from the visible to near-infrared spectral region. , Owing to these advantages of Ln-MOFs, great progress has been made in multiple optical fields of anti-counterfeiting, bioimaging, fluorescence sensing, and intelligent logic devices . However, the f–f transitions of Ln 3+ ions were forbidden and very weak, along with extinction coefficients of the order of only 0.5–3 L mol –1 cm –1 .…”

“…11,12 Remarkably, lanthanide-based MOFs (Ln-MOFs) were constructed with Ln 3+ ions as metal centers, which manifested high and flexible coordination number and connectivity and possessed fascinating luminescence properties, including large Stokes shifts, long fluorescence lifetime, linear emission, high color purity, and a wide emission range from the visible to near-infrared spectral region. 13,14 Owing to these advantages of Ln-MOFs, great progress has been made in multiple optical fields of anti-counterfeiting, bioimaging, fluorescence sensing, and intelligent logic devices. 15 However, the f−f transitions of Ln 3+ ions were forbidden and very weak, along with extinction coefficients of the order of only 0.5−3 L mol −1 cm −1 .…”

“…This work presented an unprecedented path to the water-induced luminescence enhancement of Ln 3+ ions. 13.90 mg, 0.10 mmol), N,N-dimethylacetamide (DMA, 4 mL), and concentrated nitric acid (2 μL) was placed in a Teflon-lined stainless steel autoclave (25 mL) and heated at 130 °C for 72 h. After cooling to room temperature, colorless rod-shaped crystals were obtained in a yield of 95.38% based on QXBA.…”

Bimetallic Re(i)/Pt(ii)/Pd(ii) complexes: study of synthesis and properties

“…Bimetallic transition metal compounds that contain redox-active and photoactive units have attracted considerable research attention. [1][2][3][4][5][6] These research interests stem from the fact that the multicomponent systems often have a better performance than single-component systems in various processes and applications, including solar energy conversion, [7][8][9][10] catalysis, [11][12][13][14] sensing, [15][16][17] light-emitting diode devices [18][19][20] and so forth.…”

Sniping Cancer Stem Cells with Nanomaterials

“…Recent progress in materials science, nanotechnology, and biomedicine have enabled the development of diverse nanomaterial-based drug delivery systems, including conjugated drugs, liposomes, nanoparticles, and cell-derived platforms. − These nanomaterials offer several key advantages for tumor treatment compared to traditional methods. First, nanomaterials can leverage the enhanced permeability and retention (EPR) effect to accumulate and be selectively retained within tumor tissues. − Second, nanomaterial surfaces can be facilely functionalized with proteins, peptides, and biomolecules to enhance targeting precision. − Third, nanomaterials provide protection for encapsulated drugs, genes, and therapeutic agents, shielding them from degradation in physiologically complex microenvironments . Furthermore, stimuli-responsive nanomaterials have been developed that reduce systemic drug toxicity through triggered release in response to internal or external cues. , Notably, the diversification of nanomaterial-based delivery systems continues to broaden the range of applications in cancer treatment while propelling clinical translation. , Numerous research interests have been directed toward developing clinical agents to target CSCs, with the application of nanomaterials for precision CSCs targeting becoming a key topic. − However, there remains a lack of systematic reviews comprehensively examining the utility of diverse nanomaterial types across the breadth of recently developed CSC-targeted strategies, including bioengineered nanostructures and advanced delivery platforms.…”