Lanthanide complexes for drug delivery and therapeutics

Bao, Guochen

doi:10.1016/j.jlumin.2020.117622

Cited by 50 publications

(31 citation statements)

References 95 publications

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“…Light-harvesting techniques therefore employ coordination to organic molecules 2 , or doping into strongly-absorbing inorganic chromophore systems 3 . Organic complexes of lanthanide ions comprise a burgeoning research area with a wide spectrum of applications: optical and magnetic resonance imaging 4 , 5 , contactless thermometry 6 , drug delivery 7 , and organic light-emitting diodes 8 , for example. In optical applications, the properties of the triplet state (T 1 : Fig.…”

Section: Introductionmentioning

confidence: 99%

Charging and ultralong phosphorescence of lanthanide facilitated organic complex

Thor

Wang

et al. 2021

Nat Commun

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Emission from the triplet state of an organo-lanthanide complex is observed only when the energy transfer to the lanthanide ion is absent. The triplet state lifetime under cryogenic conditions for organo-lanthanide compounds usually ranges up to tens of milliseconds. The compound LaL1(TTA)3 reported herein exhibits 77 K phosphorescence observable by the naked eye for up to 30 s. Optical spectroscopy, density functional theory (DFT) and time-dependent DFT techniques have been applied to investigate the photophysical processes of this compound. In particular, on-off continuous irradiation cycles reveal a charging behaviour of the emission which is associated with triplet-triplet absorption because it shows a shorter rise lifetime than the corresponding decay lifetime and it varies with illumination intensity. The discovery of the behaviour of this compound provides insight into important photophysical processes of the triplet state of organo-lanthanide systems and may open new fields of application such as data encryption, anti-counterfeiting and temperature switching.

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Section: Introductionmentioning

confidence: 99%

Charging and ultralong phosphorescence of lanthanide facilitated organic complex

Thor

Wang

et al. 2021

Nat Commun

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“…Thus, these particles have been currently developed as exceedingly promising imaging probes for nanomedicinal applications. For instance, Ln 3+ -doped inorganic luminescent nanoparticles was developed as a donor for fluorescence resonance energy transfer (FRET) [ 14 ], bimodal (PET/MRI) imaging probe [ 15 ], and in-vitro analysis of tumor markers [ 16 ], MR contrast agents [ 17 ], cell-labeling and tracking [ 18 ], animal imaging [ 19 ], drug delivery system [ 20 ], photodynamic therapy (PDT) [ 21 ], and photothermal therapy [ 22 ]. Therefore, integration of lanthanide complexes into cavities of MSN has enhanced the photo- and thermal stabilities and against photobleaching [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Real-Time Tracking of Highly Luminescent Mesoporous Silica Particles Modified with Europium β-Diketone Chelates in Living Cells

et al. 2021

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Highly luminescent europium complexes modified mesoporous silica particles (MSP) were synthesized as an imaging probes for both in-vitro diagnostic and in-vivo cellular tracking agents. Europium β-diketone chelates (4,4,4-trifluoro-l-(2-thienyl)-l,3-butanedione) trioctylphosphine europium (III) (Eu(TTA)3(P(Oct)3)3) were incorporated inside the nanocavities that existed in hierarchical MSP (Eu@MSP). The MSP and Eu@MSP on mouse bone marrow-derived macrophages (BMDMs) did not show any toxic effect. The MSP and Eu@MSP in the BMDMs were found at cytoplasm without any degradation and immunogenicity. However, both pro- and anti-inflammatory cytokines of macrophages were significantly increased when lipopolysaccharide and a high concentration (100 μg/mL) of MSP and Eu@MSP were treated simultaneously.

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Section: Introductionmentioning

confidence: 99%

“…For this reason, interest in these compounds has been increasing for the last half-century. Due to their characteristic photophysical and magnetic properties, their use in magnetic and optical devices [1-6], sensor systems [7], biological analysis applications [8-10], and medical diagnostic devices [11][12][13][14] is increasing.Rare earth metal cations prefer to form metal complexes with high coordination numbers with hard Lewis-based donors such as F, O, and N due to their strong Lewis acid character and large ionic radii. The carboxylic acids containing strong Lewis donor atoms, such as O and N, and polyaminopolycarboxylic acids are among the most suitable coordination ligands for rare earth metal cations with 3+ oxidation steps and meet the high coordination numbers needed [15,16].Today, in biological applications, clinical studies, NLO (nonlinear optics) applications, OLED (organic light-emitting diode) applications, MOF (metal-organic framework) compounds [17][18][19] and even corrosion inhibitors with traditional and toxic chromate-based compounds demonstrated potential for use [20].…”

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confidence: 99%

Novel mixed ligand coordination compounds of some rare earth metal cations containing acesulfamato/N,N-diethylnicotinamide

Zeybel

Köse

2021

Turk J Chem

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The mixed ligand coordination compounds containing acesulfamato and N,N -diethylnicotinamide biomolecules of some rare earth metal cations (Eu 3+ , Tb 3+ , Ho 3+ , Er 3+ and Yb 3+ ) were synthesized, and their structural properties were investigated. Possible structural formulas have been proposed by determining the chemical composition of molecules (elemental analysis), binding properties (infrared spectroscopy, mass analysis, solid-state UV-vis spectroscopy), thermal degradation properties (TGA / DTA curves). Based on the data collected, it is suggested that rare earth metal cations with a 3+ oxidation state have sextet coordination. The geometries of the structures were thought to be distorted octahedral. The charge balance of the coordination sphere is balanced by a monoanionic acesulfamato located outside the coordination sphere. When the thermal behaviours of the complexes were examined, it was determined that the compounds with Eu 3+ , Tb 3+ , and Yb 3+ metal cations contained one hydrate water outside the coordination sphere. Hydrate waters do not exist in the Ho 3+ and Er 3+ metal cation-centred complexes. At the end of the thermal decomposition analysis of all complex structures, it was determined that they leave the relevant metal oxides in the reaction vessels as final decomposition products.

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Lanthanide complexes for drug delivery and therapeutics

Cited by 50 publications

References 95 publications

Charging and ultralong phosphorescence of lanthanide facilitated organic complex

Charging and ultralong phosphorescence of lanthanide facilitated organic complex

Real-Time Tracking of Highly Luminescent Mesoporous Silica Particles Modified with Europium β-Diketone Chelates in Living Cells

Novel mixed ligand coordination compounds of some rare earth metal cations containing acesulfamato/N,N-diethylnicotinamide

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