Lanthanide-based MOFs: synthesis approaches and applications in cancer diagnosis and therapy

Sun, Shengkai; Zhao, Yuewu; Wang, Jine; Pei, Renjun

doi:10.1039/d2tb01884e

“…With covalent bonds, coordinate bonds, or simple encapsulation processes, newly formed MOFs are more suitable for practical applications. 77 Amongst them, there are a number of reports available where PEG has been employed for the modification of Hf(IV)-MOFs. In one of the reports by Zheng et al on the synthesis of HUC-PEG, trihydroxybenzaldehyde and PEG5k-NH 2 were used on the outer surface (i.e., PEG capping) of amine-functionalized Hf-UiO-66 (Hf-UiO-AM), which ensured good dispersion and physiological stability of HUC-PEG in the circulation, thereby improving intratumoral drug aggregation.…”

Section: One-pot Solvothermal Methodsmentioning

confidence: 99%

“…With covalent bonds, coordinate bonds, or simple encapsulation processes, newly formed MOFs are more suitable for practical applications. 77 Amongst them, there are a number of reports available where PEG has been employed for the modification of Hf( iv )-MOFs. In one of the reports by Zheng et al on the synthesis of HUC–PEG, trihydroxybenzaldehyde and PEG5k-NH 2 were used on the outer surface ( i.e.…”

Section: Introductionmentioning

confidence: 99%

Current and promising applications of Hf(iv)-based MOFs in clinical cancer therapy

Liu

¹

,

Chen

²

,

Lu

³

et al. 2023

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“…Herein, we present the recent advances in metal-organic frameworks (MOFs) [ 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 ], covalent organic frameworks (COFs) [ 44 , 45 , 46 , 47 , 48 , 49 ], and porous coordination cages (PCCs) [ 50 , 51 , 52 ] for cancer therapy, mainly in bioimaging, and treatments using photothermal therapy, thermodynamic therapy, or a combination of different therapies in cancer therapy ( Scheme 1 ). We highlight the applications of porous framework materials for bioimaging and cancer therapy in this article ( Table 1 ).…”

Section: Introductionmentioning

confidence: 99%

Porous Framework Materials for Bioimaging and Cancer Therapy

Meng

¹

,

Zhao

²

,

Guan

³

et al. 2023

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Cancer remains one of the most pressing diseases in the world. Traditional treatments, including surgery, chemotherapy, and radiotherapy still show certain limitations. Recently, numerous cancer treatments have been proposed in combination with novel materials, such as photothermal therapy, chemodynamic therapy, immunotherapy, and a combination of therapeutic approaches. These new methods have shown significant advantages in reducing side effects and synergistically enhancing anti-cancer efficacy. In addition to the above approaches, early diagnosis and in situ monitoring of lesion areas are also important for reducing side effects and improving the success rate of cancer therapy. This depends on the decent use of bioimaging technology. In this review, we mainly summarize the recent advances in porous framework materials for bioimaging and cancer therapy. In addition, we present future challenges relating to bioimaging and cancer therapy based on porous framework materials.

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“…Applications include gas separation, storage and conversions, − catalysis, − and conductivity and magnetism, − to name a few. Trivalent and tetravalent metal nodes are composed of some of the most stable and widely used MOFs, i.e., Cr III , , Ln III , , and Ti/Zr/Hf IV , − due to the relative stability of the bond connecting the linker (usually carboxylate) and the node.…”

Section: Introductionmentioning

confidence: 99%

Bismuth Coordination Polymers with Fluorinated Linkers: Aqueous Stability, Bivolatility, and Adsorptive Behavior

Lulich

¹

,

Amiri

²

,

Stephen

³

et al. 2023

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Bismuth metal–organic frameworks and coordination polymers (CP) are challenging to synthesize, given the poor solubility of bismuth precursors and asymmetric and labile ligation of Bi 3+ due to its intrinsic lone pair. Here, we synthesize and structurally characterize three Bi 3+ -CPs, exploiting a tetrafluoroterephtalate (F 4 BDC) linker to determine the effect of high acidity on these synthesis and coordination challenges. Single-crystal X-ray diffraction characterization showed that pi–pi stacking of linkers directs framework arrangement and generally deters open porosity in the three structures, respectively featuring Bi chains ( Bi chain -F 4 BDC ), Bi dimers ( Bi 2 -F 4 BDC ) linked into chains, and Bi tetramers ( Bi 4 -F 4 BDC ). Powder X-ray diffraction and microscopic imaging show the high purity and stability of these compounds in water. Naphthalenedisulfonate (NDS) was used as a mineralizer in the synthesis of ( Bi chain -F 4 BDC ) and ( Bi 4 -F 4 BDC ), and studies of its role in assembly pathways yielded two additional structures featuring mixed NDS and F 4 BDC, respectively, linking monomer and octamer Bi nodes, and confirmed that F 4 BDC is the preferred (less labile) linker. Methylene blue (MB) adsorption studies show differing efficacies of the three Bi-F 4 BDC phases, attributed to surface characteristics of the preferential growth facets, while generally most effective adsorption is attributed to the hydrophobicity of fluorinated ligands. Finally, thermogravimetric analysis of all three Bi-F 4 BDC phases indicates simultaneous ligand degradation and in situ formation of volatile Bi compounds, which could be exploited in the chemical vapor deposition of Bi-containing thin films.

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Lanthanide-based MOFs: synthesis approaches and applications in cancer diagnosis and therapy

Abstract: Metal-organic frameworks (MOFs) have attracted much attention as an emerging nanomaterial. Based on their tunable size, high porosity, and large specific surface area, MOFs have a wide range of applications...

Cited by 20 publications

References 171 publications

Current and promising applications of Hf(iv)-based MOFs in clinical cancer therapy

Current and promising applications of Hf(iv)-based MOFs in clinical cancer therapy

Porous Framework Materials for Bioimaging and Cancer Therapy

Bismuth Coordination Polymers with Fluorinated Linkers: Aqueous Stability, Bivolatility, and Adsorptive Behavior

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