Lanthanide-based luminescence probes and time-resolved luminescence bioassays

Yuan, Jingli; Wang, Guilan

doi:10.1016/j.trac.2005.11.013

Cited by 192 publications

(135 citation statements)

References 148 publications

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“…The synthesis and spectroscopy of upconverted nanoparticles have garnered substantial consideration due to their potential use as biolabels and in biological assays. [6,28,63,127,128] Recent developments in water-soluble upconverted lanthanide phosphors have provided a novel approach for designing extremely luminescent and photostable lanthanide nanoprobes. [22] As luminescence probes, the main advantage of upconverting nanoparticles is that the interference of background noises with luminescence detection can be avoided, as they have an excitation wavelength at 980 nm and short emission wavelengths in the visible-light range, whereas no biological matrix upconverts in the infrared range.…”

Section: Applicationsmentioning

confidence: 99%

Lanthanide‐Doped Nanocrystals: Strategies for Improving the Efficiency of Upconversion Emission and Their Physical Understanding

2014

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The fundamental understanding of lanthanide-doped upconverted nanocrystals remains a frontier area of research because of potential applications in photonics and biophotonics. Recent studies have revealed that upconversion luminescence dynamics depend on host crystal structure, size of the nanocrystals, dopant concentration, and core-shell structures, which influence site symmetry and the distribution and energy migration of the dopant ions. In this review, we bring to light the influences of doping/co-doping concentration, crystal phase, crystal size of the host, and core-shell structure on the efficiency of upconversion emission. Furthermore, the lattice strain, due to a change in the crystal phase and by the core-shell structure, strongly influences the upconversion emission intensity. Analysis suggests that the local environment of the ion plays the most significant role in modification of radiative and nonradiative relaxation mechanisms of overall upconversion emission properties. Finally, an outlook on the prospects of this research field is given.

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Section: Applicationsmentioning

confidence: 99%

Lanthanide‐Doped Nanocrystals: Strategies for Improving the Efficiency of Upconversion Emission and Their Physical Understanding

2014

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“…But the ions' poor ability to absorb light makes it necessary to dress them up with an organic ligand as a skin in the form of a complex. 1 The complexes have become increasingly significant in the last few years due to the wide variety of potential applications in many important areas of chemistry, [2][3][4] biology, [5][6] medicine [7][8] and imaging. [9][10][11][12] The design of the organic part of such complexes is thus paramount in achieving the required circumstances for the complex to be efficiently luminescent.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Luminescence Properties of Lanthanide Complexes of a Novel Polyaminopolycarboxylate Ligand

Tang¹,

Tang²,

Tang³

et al. 2010

Bulletin of the Korean Chemical Society

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A novel polyaminopolycarboxylate ligand with many coordination sites, N,N,N 1 ,N 1 ,N 2 ,N 2 -[( 2,4,6-tri(aminomethyl)-pyridine]hexakis(acetic acid) (TPHA), was designed and synthesized and its lanthanide complexes Na6Tb2(TPHA)Cl6· 14H2O, Na6Eu2(TPHA)Cl6·8H2O, Na6Gd2(TPHA)Cl6·11H2O and Na6Sm2(TPHA)Cl6·9H2O were successfully prepared. The ligand and the complexes were characterized by elemental analysis, IR, mass, NMR and TG-DTA. The TG-DTA studies indicated that the complexes had a high thermal stability, whose initial decomposition temperature was over 270 o C. The luminescence properties of the complexes in solid state were investigated and the results suggested that Tb 3+ and Eu 3+ ions could be sensitized efficiently by the ligand, especially the Tb(III) complex displayed a very strong luminescence intensity (> 10000) and only displayed characteristic metal-centered luminescence. Also, the correlative comparison between the structure of ligand and luminescence properties showed how the number of the coordination atoms of ligand can be a prominent factor in the effectiveness of ligand-to-metal energy transfer.

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“…9 The use of welldesigned lanthanide complexes as probes for spectroscopy 10 or microscopy 11 can be advantageous due to their unique properties. They exhibit long-lived emission, allowing for sensitive time-gated detection 12 (well-defined, narrow peaks in the emission spectrum allow for more complex analysis), and have large Stokes' shifts, of hundreds of nanometres. Several examples exhibit dynamic responses to local conditions such as pH or bicarbonate 13 , allowing the measurement of these parameters within particular organelles of mammalian cells.…”

Section: Transgenic Tobacco By-2 Cells Andmentioning

confidence: 99%

Emissive europium complexes that stain the cell walls of healthy plant cells, pollen tubes and roots

Palmer¹,

Ford²,

Butler³

et al. 2014

RSC Adv.

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Publisher's copyright statement: Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. ] that contains one azathiaxanthone chromophore.Internalisation only occurred in cells that had been deliberately permeabilised or were dying. No uptake was observed within healthy plant leaves. In root hairs, the cell wall was strongly stained as well as the mitochondria, revealed by time-lapsed microscopy that showed the tumbling of the mitochondria in the living tissue, confirmed by co-localisation studies. In pollen tubes, the cell wall was also stained; rapid bursting of the pollen tip occurred following incubation with [Eu.L 1 ], triggered by excitation with 405 nm laser light. Such behaviour is consistent with local perturbation of cell wall permeability and integrity, associated with the reactivity of the chromophore triplet excited state.

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Lanthanide-based luminescence probes and time-resolved luminescence bioassays

Cited by 192 publications

References 148 publications

Lanthanide‐Doped Nanocrystals: Strategies for Improving the Efficiency of Upconversion Emission and Their Physical Understanding

Lanthanide‐Doped Nanocrystals: Strategies for Improving the Efficiency of Upconversion Emission and Their Physical Understanding

Synthesis and Luminescence Properties of Lanthanide Complexes of a Novel Polyaminopolycarboxylate Ligand

Emissive europium complexes that stain the cell walls of healthy plant cells, pollen tubes and roots

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