Lantana macrophylla Schauer (Verbenaceae) ethanolic extract induces activation of ERK1/2 and p38 MAPKs pathway and Ca2+ imbalance in human trophoblasts derived cell lines

Conceição, Aline Oliveira da; Oliveira, Fernando A.; Oliveira, Rosilene Aparecida de; S., Ademir de J. da; Takser, Larissa; Reyes‐Moreno, Carlos; Lafond, Julie

doi:10.1016/j.fct.2011.12.021

Cited by 7 publications

(3 citation statements)

References 66 publications

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“…In fact, p38 MAPK activation was also reported in OAtreated trophoblasts derived cell lines and vascular smooth muscle cells (Martinez-Gonzalez et al, 2008;Feng et al, 2011a;da Conceicao et al, 2012). However, OA failed to activate this signaling pathway in some other types of normal cells , indicating that the response of p38 MAPK pathway status to OA stimulation depend on cell types.…”

Section: Discussionmentioning

confidence: 86%

p38 MAPK Signaling Mediates Mitochondrial Apoptosis in Cancer Cells Induced by Oleanolic Acid

Liu¹,

Wu²,

Ma³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Oleanolic acid (OA) is a nutritional component widely distributed in various vegetables. Although it has been well recognized for decades that OA exerts certain anti-tumor activity by inducing mitochondria-dependent apoptosis, it is still unclear that what molecular signaling is responsible for this effect. In this study, we employed cancer cell lines, A549, BXPC-3, PANC-1 and U2OS to elucidate the molecular mechanisms underlying OA antitumor activity. We found that activation of MAPK pathways, including p-38 MAPK, JNK and ERK, was triggered by OA in both a dose and time-dependent fashion in all the tested cancer cells. Activation was accompanied by cleavage of caspases and PARP as well as cytochrome C release. SB203580 (p38 MAPK inhibitor), but not SP600125 (JNK inhibitor) and U0126 (ERK inhibitor), rescued the pro-apoptotic effect of OA on A549 and BXPC-3 cells. OA induced p38 MAPK activation promoted mitochondrial translocation of Bax and Bim, and inhibited Bcl-2 function by enhancing their phosphorylation. OA can induce reactive oxygen species (ROS)-dependent ASK1 activation, and this event was indispensable for p38 MAPK-dependent apoptosis in cancer cells. In vivo, p38 MAPK knockdown A549 tumors proved resistant to the growth-inhibitory effect of OA. Collectively, we elucidated that activation of ROS/ASK1/p38 MAPK pathways is responsible for the apoptosis stimulated by OA in cancer cells. Our finding can contribute to a better understanding of molecular mechanisms underlying the antitumor activity of nutritional components.

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Section: Discussionmentioning

confidence: 86%

p38 MAPK Signaling Mediates Mitochondrial Apoptosis in Cancer Cells Induced by Oleanolic Acid

Liu¹,

Wu²,

Ma³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…However, recent studies contradict this, showing considerable antioxidant and free radical chelating activity in vitro by lantadenes, which would mean a potential cytoprotective effect [125]. Other species under study are Lantana montevidensis Briq (potential antibacterial) [126], Lantana cramera (insecticidal activity) [127], Lantana macrophylla Schauer (placental and trophoblast toxicity) [128], among others.…”

Section: Potential Of Lantana Sppmentioning

confidence: 99%

Arsenic Immunotoxicity and Immunomodulation by Phytochemicals: Potential Relations to Develop Chemopreventive Approaches

Elizagaray¹,

Soria

2014

IAD

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Arsenic (As) contaminates drinking water worldwide, and As exposure, hypersensitivity and deficiency are involved in the immunopathogenesis of various health problems. Its chemoprevention thus has a high health impact. Given its oxidative potential, antioxidant compounds are good candidates to counteract arsenic's deleterious effects on humans. Phytochemicals (e.g., phenolics, carotenoids, etc.) act through free radical chelation activity and regulation of cellular targets. Consequently, they are appropriate for developing anti-As strategies derived from plants, and Argentinean flora is rich in useful species. Several molecular pathways involved in immune regulation are at the same time targets of exogenous agents, and oxidative stress itself is a modulating phenomenon of immunity. Since xenohormesis has been described as the organic enhancement of resistance to stress conditions (e.g., oxidation, pollution, etc.) by consuming xenobiotics, immunoxenohormesis implies also defense improvement. This review focuses on recent patents on the development of vegetable redox-related immunomodulating agents, which might be applied in As-induced dysfunctions, with their scientific basis being reviewed.

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“…and depressant like effect [8]. Terpenoids affect the intracellular calcium ions and facilitated the inhibition of calcium ion (Ca 2+ ) influx through L-type Ca 2+ channels [9,10].…”

Section: Introductionmentioning

confidence: 99%

Biochemical and ultrastructural alterations in the brain of mice induced by aqueous leaf extract of a medicinal plant, Lantana camara L. and its amelioration by nimodipine and flunarizine

Ashalata¹,

Sengupta²,

Bawari³

2021

J App Biol Biotech

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Lantana camara L., a plant used as an ethnomedicine, is considered to be toxic. In this context, evaluation of neurotoxic effect of L. camara was studied. Here, experimental mice were orally administered with an aqueous leaf extract of L. camara (AQLC) (500 mg/kg body weight) for 14 days. Biochemical assays, acetylcholinesterase (AChE) activity as well as microscopic studies were performed to assess its neurotoxic effects. Administration (per oral) of AQLC in mice induced significant oxidative damage in the brain cortex and cerebellum as evidenced by increased lipid peroxidation, protein carbonylation, and also the activity of AChE. This was associated with declining of the endogenous antioxidants such as superoxide dismutase and glutathione peroxidase. Co-treatment of calcium channel blockers, nimodipine (20 mg/kg body weight) and flunarizine (10 mg/kg body weight) along with the aqueous extract of L. camara were seemed to ameliorate the neurotoxic effect caused by AQLC. Furthermore, disintegration in the ultrastructure of brain cortex induced by L. camara was restored by treating calcium channel blockers. Altogether, the findings of this study concluded that the AQLC has potential neurotoxic effect in mice.

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Lantana macrophylla Schauer (Verbenaceae) ethanolic extract induces activation of ERK1/2 and p38 MAPKs pathway and Ca2+ imbalance in human trophoblasts derived cell lines

Cited by 7 publications

References 66 publications

p38 MAPK Signaling Mediates Mitochondrial Apoptosis in Cancer Cells Induced by Oleanolic Acid

p38 MAPK Signaling Mediates Mitochondrial Apoptosis in Cancer Cells Induced by Oleanolic Acid

Arsenic Immunotoxicity and Immunomodulation by Phytochemicals: Potential Relations to Develop Chemopreventive Approaches

Biochemical and ultrastructural alterations in the brain of mice induced by aqueous leaf extract of a medicinal plant, Lantana camara L. and its amelioration by nimodipine and flunarizine

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