Lantana canescens (Kunth) inhibits inflammatory and hyperalgesic responses in murine models

Lencina, Jóyce dos Santos; Moslaves, Iluska Senna Bonfá; Muller, Jéssica de Araújo Isaías; Carvalho, Raquel; Amianti, Carolina; Bonfim, Izadora; Alves, Flávio Macêdo; Carollo, Carlos Alexandre; Portugal, Luciane Candeloro; Júnior, Antonio Alves dos Santos; Silva, Denise Brentan; Toffoli-Kadri, Mônica Cristina

doi:10.1016/j.jep.2021.114461

Cited by 3 publications

(5 citation statements)

References 56 publications

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“…These data corroborated the high antioxidant activity values presented by the L. camara extracts, since they were rich in phenolic compounds. Some of the compounds were identified previously in L. camara and/or other species of this genus 7,15,16,21,68–72 . The combination of FT‐Orbitrap MS information with that of several reports in the literature corroborated the proposed identification of iridoids, terpenoids, phenolic acids, phenylpropanoids, and flavonoids present in the extracts.…”

Section: Resultssupporting

confidence: 80%

“…Some of the compounds were identified previously in L. camara and/or other species of this genus. 7,15,16,21,[68][69][70][71][72] The combination of FT-Orbitrap MS information with that of several reports in the literature corroborated the proposed identification of iridoids, terpenoids, phenolic acids, phenylpropanoids, and flavonoids present in the extracts. However, it is important to emphasize that FT-Orbitrap MS is a qualitative technique.…”

Section: Comparison Among Mae Uae and Conventional Extraction Methodssupporting

confidence: 79%

“…The exact masses of the ions produced in negative ionization mode [M − H] − could be converted to molecular formulas. The chemical structures were proposed based on data available in the literature for the identification of chemical compounds present in extracts from L. camara and/or different species of the genus Lantana , 7,15,16,21,68–72 as well databaseas in the PubChem 73…”

Section: Resultsmentioning

confidence: 99%

“…7,16 Strong correlation between TPC and/or TFC and antioxidant activities of plant extracts has been reported previously. 7,15,16,21,[68][69][70][71][72] as well databaseas in the PubChem. 73 Table 3 shows the theoretical masses of the ions in ascending S3 to S8).…”

Section: Comparison Among Mae Uae and Conventional Extraction Methodsmentioning

confidence: 99%

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Microwave and ultrasound extraction of antioxidant phenolic compounds from Lantana camara Linn. leaves: Optimization, comparative study, and FT‐Orbitrap MS analysis

de Jesus,

da Silva,

Wisniewski

et al. 2024

Phytochemical Analysis

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IntroductionThe species Lantana camara is used in folk medicine. The biological activities of this medicinal plant are attributable to the presence of various derivatives of triterpenoids and phenolic compounds present in its preparations, indicating excellent economic potential.ObjectiveIn this study, the operational conditions of ultrasound‐assisted extraction (UAE) and microwave‐assisted extraction (MAE) were optimized using Box–Behnken design to improve the total phenolic content (TPC) recovered in hydroethanolic extracts of L. camara leaves.Material and methodsThe TPC, total flavonoid content (TFC), and antioxidant activities of the hydroalcoholic extracts of L. camara, prepared by UAE and MAE under the optimized extraction conditions, were compared with those of the extracts obtained by conventional extraction methods.ResultsUnder the optimal conditions, the extracts obtained by UAE (35% ethanol, 25 min, and a solvent‐to‐solid ratio of 60:1 mL/g) and by MAE (53% ethanol, 15 min, and 300 W) provided high yields of 32.50% and 38.61% and TPC values of 102.89 and 109.83 mg GAE/g DW, respectively. The MAE extract showed the best results with respect to TPC, TFC, and antioxidant activities, followed by extracts obtained by UAE, Soxhlet extraction, decoction, maceration, and infusion, in that order.ConclusionThe results obtained indicate that L. camara may be used as an important source of antioxidant phenolic compounds to obtain products with high biological and economic potential, especially when the extraction process is performed under appropriate conditions using MAE and/or UAE, employing environmentally friendly solvents such as water and ethanol.

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Section: Resultssupporting

confidence: 80%

Section: Comparison Among Mae Uae and Conventional Extraction Methodssupporting

confidence: 79%

Section: Resultsmentioning

confidence: 99%

Section: Comparison Among Mae Uae and Conventional Extraction Methodsmentioning

confidence: 99%

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Microwave and ultrasound extraction of antioxidant phenolic compounds from Lantana camara Linn. leaves: Optimization, comparative study, and FT‐Orbitrap MS analysis

de Jesus,

da Silva,

Wisniewski

et al. 2024

Phytochemical Analysis

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“…Similarly, previous studies have shown that the high polarity of acetone was found to exhibit better efficiency in extracting various polar phytocompounds, such as phenolics, from the leaves of L. camara [102]. In several studies, it was proven that the leaf extracts of L. camara have antiinflammatory [103]; anticancer [104], antibacterial [105], antifungal, insecticidal [106], and nematocidal activities [107].…”

Section: Phytochemical Analysismentioning

confidence: 86%

Evaluation of four ornamental plant extracts as insecticidal, antimicrobial, and antioxidant against the West Nile vector, Culex pipiens (Diptera: Culicidae) and metabolomics screening for potential therapeutics

Baz,

Mostafa,

Ebeed

et al. 2023

Preprint

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Mosquitoes, one of the deadliest animals on the planet, cause millions of fatalities each year by transmitting several human illnesses. Phytochemicals are possible biological agents for controlling pests that are harmful to both human and animal health as well as crops. Plants contain a wide range of potential phytochemicals that are target-specific, rapidly biodegradable, and eco-friendly. The potential of leaf extracts of Bougainvillea glabra, Delonix regia, Lantana camara, and Platycladus orientalis against Culex pipiens and microbial agents was evaluated. Acetone extracts had more toxic effects against Cx. pipiens larvae (99.0–100%, 72 h post-treatment), and the LC50 values were 142.8, 189.5, 95.4, and 71.1 for B. glabra, D. regia, L. camara, and P. orientalis, respectively. Plant extracts tested in this study showed high insecticidal and antimicrobial potential. L. camara acetone extract inhibited all the tested microbial isolates. D. regia showed higher antioxidant activity than other plant extracts in scavenging free radicals. GC-MS results showed the acetone extract had a higher number of chemical classes, with more terpene compounds. HPLC analysis showed the presence of flavonoids and phenolic compounds in L. camara and P. orientalis acetone extracts, and Sylimarine and Rutin were the most abundant. ADME analysis of elemene, caryophyllene oxide, caryophyllene, and copaene showed drug-likeness and revealed better gastrointestinal absorption and permeation of the blood-brain barrier by all the tested phytochemicals. Our results confirm that the diversity of phytochemicals found in ornamental plants has promising larvicidal activity and is a safe and effective alternative to chemical insecticides and biotechnology.

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Comparative LC–LTQ–MS–MS Analysis of the Leaf Extracts of Lantana camara and Lantana montevidensis Growing in Egypt with Insights into Their Antioxidant, Anti-Inflammatory, and Cytotoxic Activities

El-Din

Fahmy

et al. 2022

Plants

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Lantana camara L. and Lantana montevidensis Briq. (F. Verbenaceae) are invasive ornamental weeds native to the tropical regions of Africa and America. The leaves of both species have been traditionally used as infusions for treating fever, rheumatism, and cancer. LC–MS–MS-guided profiling of the methanolic extracts of the leaves of L. camara and L. montevidensis growing in Egypt led to the putative identification of 59 compounds belonging to terpenoids, flavonoids, iridoid glycosides, phenolic acids, and their derivatives. The in-vitro antioxidants and anti-inflammatory and anticancer activities of the two extracts were investigated. L. camara and L. montevidensis inhibited DPPH• (IC50 = 34.01 ± 1.32 and 47.43 ± 1.74 µg/mL), ABTS+ (IC50 = 30.73 ± 1.42 and 40.37 ± 1.51 µg/mL), and superoxide anion (IC50 = 1.57 ± 0.19 and 1.31 ± 0.14 μg/mL) free radicals. A potent anti-inflammatory effect was observed for both species through the inhibition of elastase release in fMLF/CB-induced human neutrophils (IC50 = 2.40 ± 0.16 and 1.90 ± 0.07 μg/mL). The extracts showed significant cytotoxic activity against a panel of cancer cell lines with the most potent activity against Caco cells (IC50 = 45.65 ± 1.64 and 40.67 ± 1.52 µg/mL for L. camara and L. montevidensis, respectively). Western blotting supported by FACS analysis revealed that the extracts inhibited cancer cell proliferation, reduced metastasis, and induced apoptosis resulting in cell cycle arrest. This was achieved via increasing mRNA and protein expressions of p53 and GSK-3β as well as decreasing the expression of PI3K, Akt, and cyclin D1.

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Lantana canescens (Kunth) inhibits inflammatory and hyperalgesic responses in murine models

Cited by 3 publications

References 56 publications

Microwave and ultrasound extraction of antioxidant phenolic compounds from Lantana camara Linn. leaves: Optimization, comparative study, and FT‐Orbitrap MS analysis

Microwave and ultrasound extraction of antioxidant phenolic compounds from Lantana camara Linn. leaves: Optimization, comparative study, and FT‐Orbitrap MS analysis

Evaluation of four ornamental plant extracts as insecticidal, antimicrobial, and antioxidant against the West Nile vector, Culex pipiens (Diptera: Culicidae) and metabolomics screening for potential therapeutics

Comparative LC–LTQ–MS–MS Analysis of the Leaf Extracts of Lantana camara and Lantana montevidensis Growing in Egypt with Insights into Their Antioxidant, Anti-Inflammatory, and Cytotoxic Activities

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