Lantana camara L. (Verbenaceae)

Ghisalberti, Emilio L.

doi:10.1016/s0367-326x(00)00202-1

Cited by 354 publications

(293 citation statements)

References 77 publications

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“…The aforementioned data were coherent with a non aromatic abietane-type diterpene that displays an epoxy ring, a tertiary hydroxyl group, an α,β-unsaturated-γ-lactone system and two double bonds, having some similarities with the diterpene triptolide. 12 The location of these functions in the abietane skeleton was deduced through additional HMBC analysis (Table 1), which revealed the following long-range correlations: the epoxy hydrogens at d is generally present in abietane-type diterpenoids. 13 Finally, the butenolide ring involving the carbons C-3, C-4, C-18 and C-19 was located by the correlations of the methylene hydrogens at d 67 (H-6α) and 1.07 (H-7α).…”

Section: Resultsmentioning

confidence: 99%

Diterpene and other constituents from Stemodia maritima (Scrophulariaceae)

Rodrigues¹,

Lima²,

Oliveira³

et al. 2010

J. Braz. Chem. Soc.

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Section: Resultsmentioning

confidence: 99%

Diterpene and other constituents from Stemodia maritima (Scrophulariaceae)

Rodrigues¹,

Lima²,

Oliveira³

et al. 2010

J. Braz. Chem. Soc.

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“…Its toxicity was also showed in ruminant grazing animals (Tokarnia et al, 1999). On the other hand, therapeutics characteristics of this plant should be considered once the population uses it to treat several health disorders as respiratory diseases, rheumatisms, malaria, dysenteries, headache, hypertension and cancer (Ghisalberti, 2000;Deena & Thoppil, 2000). The literature has shown that the essential oil from leaves of L. camara (EOLC) was able to play as an anti-inflammatory agent in vivo and has a potential antimicrobial action in vitro (Deena & Thoppil, 2000).…”

Section: Introductionmentioning

confidence: 99%

Essential oil from leaves of Lantana camara: a potential source of medicine against leishmaniasis

Machado

Valente²,

Lesche³

et al. 2012

Rev. bras. farmacogn.

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Abstract:Leishmaniasis is an infection of viscera or tegument caused by protozoa Leishmania sp. The extensive period required for the treatment, which involves the use of toxic medicines, leads patients to drop treatment increasing the development of resistant forms of Leishmania sp. Lantana camara L., Verbenaceae, is a tropical plant native from America. Folk uses have been described for treatment of tumors, tetanus, rheumatism and malaria. This study evaluates the leishmanicidal activity of the essential oil of leaves from L. camara on promastigote forms of Leishmania chagasi and L. amazonensis and its toxic effects on Artemia salina (brine shrimp test), macrophage cultures and BALB/c mice. The chemical composition was evaluated using the gas chromatography coupled with mass spectrometer (GC-MS). Thirty substances, mostly mono and sesquiterpenes were identifi ed. The most representative constituents were: germacrene D (24.90%), farnesene derivatives (22%) and (E)-cariophylene (14.31%). Bioassays revealed a signifi cant leishmanicidal activity of essential oil against L. amazonensis (IC50 0.25 μg/ mL) and a potential toxic effect on Brine shrimp (LC50 10 μg/mL) and macrophage assays (CC50 4 μg/mL), while there was no toxic manifestation on mice. The data show the relevant potential of L. camara as a source of medicine for leishmaniasis treatment.

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“…Kauranes are intermediates in the biosynthesis of a number of plant and fungal metabolites, including the gibberellins and other phytohormones involved in the regulation of growth and development of higher plants. 6 Kaurenoic acid (1), along with several related kauranes, 7 exhibits a wide variety of biological activities such as antimicrobial, anti-inflammatory, anti-fertility, cytotoxic, and trypanocidal. [8][9][10][11][12][13][14][15][16] The relatively high natural abundance of kaurenoic acid (1) and the inexistence of a general method for the synthesis of alkyl kaurenoates by esterification of 1 provides further motivation to investigate its chemical modification 17 in order to obtain derivatives and test their pharmacological activity.…”

Section: Introductionmentioning

confidence: 99%

A simple synthesis of kaurenoic esters and other derivatives and evaluation of their antifungal activity

Boeck

Sá

Souza

et al. 2005

J. Braz. Chem. Soc.

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Este trabalho descreve a preparação de ésteres e amidas derivados do ácido caurenóico e a avaliação da atividade antifúngica frente a cepas padronizadas de fungos patogênicos. Ésteres alquílicos e benzílicos foram obtidos com bons rendimentos, sob condições brandas, a partir da esterificação do ácido caurenóico com haletos de alquila em KOH-acetona. Todos os compostos sintetizados foram submetidos aos testes de inibição contra leveduras, hifomicetos e dermatófitos, mas somente o ácido caurenóico e os derivados contendo um grupo carboxilato livre apresentaram atividade moderada frente a dermatófitos.Representative esters derived from kaurenoic acid were prepared in order to evaluate their antifungal properties. Alkyl and substituted benzyl esters were obtained in good yield under mild conditions by esterification of kaurenoic acid with the corresponding alkyl halide in KOH-acetone. All synthesized compounds were tested for antifungal properties against pathogenic yeasts, hialohyphomycetes and dermatophytes. Kaurenoic acid and derivatives containing a free carboxyl group were moderately active against dermatophytes.

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Lantana camara L. (Verbenaceae)

Cited by 354 publications

References 77 publications

Diterpene and other constituents from Stemodia maritima (Scrophulariaceae)

Diterpene and other constituents from Stemodia maritima (Scrophulariaceae)

Essential oil from leaves of Lantana camara: a potential source of medicine against leishmaniasis

A simple synthesis of kaurenoic esters and other derivatives and evaluation of their antifungal activity

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