Lansoprazole versus Omeprazole in Active Duodenal Ulcer a Double-Blind, Randomized, Comparative Study

Abstract

Both lansoprazole and omeprazole generate very high healing rates and good symptom relief in active duodenal ulcer. Side effects are few and mild.

Acid‐inhibitory effects of omeprazole and lansoprazole in Helicobacter pylori‐negative healthy subjects

“…With respect to healing rate, omeprazole 20 mg and lansoprazole 30 mg once daily (o.d.) have similar efficacy in the treatment of reflux oesophagitis, duodenal ulcer and Zollinger–Ellison disease 3 –5 …”

Effects of pantoprazole, a novel H+/K+‐ATPase inhibitor, on duodenal ulcerogenic and healing responses in rats: A comparative study with omeprazole and lansoprazole

“…Although many clinical studies demonstrated the effectiveness of this agent for treatment of acid-related diseases, [10][11][12][13][14] the data in experimental animals are missing. The present study clearly showed that a novel H + /K + -ATPase inhibitor pantoprazole exhibited a potent antisecretory action, anti-lesion activity against acute duodenal damage, and healing promoting action on pre-existing duodenal ulcers in rats.…”

“…8,9,22 Certainly, this agent caused a potent and prolonged suppression of gastric acid secretion, similar to other pump inhibitors such as omeprazole or lansoprazole. 9,10 Clinical studies showed that pantoprazole 40 mg daily, lansoprazole 30 mg daily and omeprazole 20 mg daily are equally effective in inducing duodenal ulcer healing, 13,22,23 and they are more effective compared with ranitidine, an H 2 receptor antagonist. 11,12,24 In the present study, we confirmed a potent antisecretory action of pantoprazole in rats for basal and stimulated acid secretion in response to mepirizole, a duodenal ulcerogen.…”

Eradication ofHelicobacter pyloriwith lansoprazole, roxithromycin and metronidazole—an open pilot study

“…They are also known to inhibit the growth of H. pylori , 5 even though eradication does not seem to be accomplished without the addition of antibiotics 6 . At standard doses all proton pump inhibitors induce similarly potent and long‐lasting acid inhibition, 7 , 8 with some authors suggesting an even slightly superior treatment efficacy for lansoprazole 9…”

“…They are also known to inhibit the growth of H. pylori, 5 even though eradication does not seem to be accomplished without the addition of antibiotics. 6 At standard doses all proton pump inhibitors induce similarly potent and long-lasting acid inhibition, 7,8 with some authors suggesting an even slightly superior treatment ef®cacy for lansoprazole. 9 To determine whether a proton pump inhibitor other than omeprazole and a macrolide different from clarithromycin would be an equally effective H. pylori therapy, we combined lansoprazole, roxithromycin and metronidazole for a 7-day regimen followed by another 7 days of acid suppression only.…”