Lansoprazole-Induced Thrombocytopenia

Zlabek, Jonathan A; Anderson, Christopher G.

doi:10.1345/aph.1a303

Cited by 27 publications

(12 citation statements)

References 2 publications

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“…No entanto, estes fármacos podem ocasionar reações adversas graves, como trombocitopenia (Zlabek & Anderson, 2002), nefrite intersticial aguda (Ra & Tobe, 2004), nefrotoxicidade e hepatotoxicidade (Fisher & Le Couteur, 2001), reações anafiláticas , ginecomastia e impotência (Sabesin, 1993).…”

Section: Introductionunclassified

Atividades antiúlcera e antioxidante do extrato de folhas de Syzygium jambos (L.) Alston (Myrtaceae)

Donatini¹,

Ishikawa²,

Barros³

et al. 2009

Rev. bras. farmacogn.

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RESUMO:Syzygium jambos (L.) Alston, Myrtaceae, é empregado na medicina popular como digestivo e antiinflamatório. A triagem fitoquímica da droga pulverizada (folhas) indicou a presença de flavonóides, taninos e óleo volátil. O extrato hidroetanólico a 70% das folhas de S. jambos foi preparado por percolação e liofilizado. O conteúdo de taninos das folhas e do extrato foi calculado, respectivamente, em 21,9% e 43,3%. O teor de flavonóides foi de 0,6% (folhas) e 1,2% (extrato). A administração oral prévia do extrato (400 mg/kg) a ratos Wistar reduziu significativamente as lesões gástricas induzidas por etanol acidificado. No modelo de úlcera subcrônica, com indução de lesão gástrica utilizando ácido acético a 30%, o tratamento com o extrato (400 mg/kg) não apresentou resultado significativo. A atividade antioxidante do extrato foi avaliada através dos modelos de lipoperoxidação e de medida de capacidade seqüestrante de radicais DPPH. Os valores obtidos de Q 1/2 (MDA) e CE 50 (DPPH) foram, respectivamente, 0,17 mg/mL e 5,68 mg/mL.Unitermos: Syzygium jambos, Myrtaceae, atividade antiúlcera, atividade antioxidante.ABSTRACT: "Antiulcerogenic and antioxidant activities of leaf extract of Syzygium jambos (L.) Alston (Myrtaceae)". Syzygium jambos (L.) Alston, Myrtaceae, is commonly employed in folk medicine as digestive and anti-inflammatory. Phytochemical screening of the powdered dried leaves indicates the presence of flavonoids, tannins and essential oil. Hydroethanol extracts (70%) were prepared by percolation and freeze-drying. The tannin content of dried leaves and extract was, respectively, 21.9% and 43.3%. The flavonoid content was 0.6% (dried leaves) and 1.2% (extract). Previous oral administration of S. jambos leaves extract (400 mg/kg) to rats reduced significantly gastric injury induced by HCl/ethanol. At the subcronic ulcer model by induction with 30% acetic acid the results were not significant. In vitro antioxidant activity of S. jambos extract was evaluated by malondialdehyde (MDA) and DPPH free radical method. The Q 1/2 for MDA assay was 0.17 mg/mL and the EC 50 for DPPH assay was 5.68 mg/mL.

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Section: Introductionunclassified

Atividades antiúlcera e antioxidante do extrato de folhas de Syzygium jambos (L.) Alston (Myrtaceae)

Donatini¹,

Ishikawa²,

Barros³

et al. 2009

Rev. bras. farmacogn.

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“…Despite the success recorded with the use of H 2 RAs and PPIs, treatment of PUD was fraught with high incidence of recurrence. Moreover, these antisecretory agents are not devoid of side effects [6,7]. Also, drugs with imidazole nucleus may cause significant drug interaction by inhibition of hepatic microsomal enzyme-cytochrome P450.…”

Section: Introductionmentioning

confidence: 99%

Effect of crude methanol leaf extract of Combretum racemosum on histamine-stimulated gastric secretion in rats

Okwuosa¹,

Azubike²,

Nwachukwu³

et al. 2017

JCLM

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“…These agents are generally well tolerated, with few commonly reported adverse effects (1). A rarely reported adverse effect consists of thrombocytopenia associated with the use of PPIs (2)(3)(4)(5). We describe a case in which the patient developed thrombocytopenia while taking intravenous pantoprazole.…”

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confidence: 96%

“…Departments of 1 Gastroenterology, 2 Internal Medicine, 3 Surgery, 4 Radiology, 5 The To the Editor, Proton-pump inhibitors (PPIs) are prescribed for treatment of peptic ulcer disease, gastroesophageal reflux disease, acute gastrointestinal bleeding, Zollinger-Ellison syndrome, and Helicobacter pylori eradication. These agents are generally well tolerated, with few commonly reported adverse effects (1).…”

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confidence: 99%

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Thrombocytopenia as a side effect of pantoprazole

Taş¹

2013

Turk J Gastroenterol

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Lansoprazole-Induced Thrombocytopenia

Abstract: Clinicians should be aware of the possible association of thrombocytopenia with lansoprazole and discontinue the drug if thrombocytopenia becomes apparent.

Cited by 27 publications

References 2 publications

Atividades antiúlcera e antioxidante do extrato de folhas de Syzygium jambos (L.) Alston (Myrtaceae)

Atividades antiúlcera e antioxidante do extrato de folhas de Syzygium jambos (L.) Alston (Myrtaceae)

Effect of crude methanol leaf extract of Combretum racemosum on histamine-stimulated gastric secretion in rats

Thrombocytopenia as a side effect of pantoprazole

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