Lansoprazole 15 mg OD is superior to ranitidine 300 mg OD in relieving heartburn and healing patients with (endoscopically confirmed) reflux oesophagitis grade I

In people with mild GERD, on-demand deprescribing may lead to an increase in GI symptoms (e.g. dyspepsia, regurgitation) and probably a reduction in pill burden. There was a decline in participant satisfaction, although heterogeneity was high. There were insufficient data to make a conclusion regarding long-term benefits and harms of PPI discontinuation, although two trials (one on-demand trial and one abrupt discontinuation trial) reported endoscopic findings in their intervention groups at study end.

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Deprescribing versus continuation of chronic proton pump inhibitor use in adults

Boghossian

Rashid

Thompson

et al. 2017

Cochrane Database of Systematic Reviews

109

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Lansoprazole 15 mg OD is superior to ranitidine 300 mg OD in relieving heartburn and healing patients with (endoscopically confirmed) reflux oesophagitis grade I

Cited by 1 publication

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Deprescribing versus continuation of chronic proton pump inhibitor use in adults

Deprescribing versus continuation of chronic proton pump inhibitor use in adults

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