Lanostane Triterpenes from the Fruiting Bodies of Ganoderma lucidum and Their Inhibitory Effects on Adipocyte Differentiation in 3T3-L1 Cells

Abstract

Four new lanostane triterpenes, butyl ganoderate A (1), butyl ganoderate B (2), butyl lucidenate N (3), and butyl lucidenate A (4), were isolated from the fruiting bodies of Ganoderma lucidum together with 14 known compounds (5-18). The structures of the new triterpenes were established by extensive spectroscopic studies and chemical evidence. In addition, the inhibitory effect of isolated compounds on adipocyte differentiation in 3T3-L1 cells was examined.

A Comprehensive Review of the Structure Elucidation and Biological Activity of Triterpenoids from Ganoderma spp.

“…In 2010, the inhibitory effect of triterpenes isolated from G. lucidum on adipocyte differentiation in 3T3-L1 cells was reported for the first time [17]. According to a report on the subsequent research, compound 249 reduced the triglyceride accumulation significantly by 72% at 80 μM and it effectively suppressed the glycerol-3-phosphate dehydrogenase activity in the cells.…”

“…Butyl lucidenate N G. lucidum (fruit bodies) [17] 223 Butyl lucidenate A G. lucidum (fruit bodies) [17] G. lucidum (fruit bodies) [90] 229 Lucidenic acid N (3,7-dihydroxy-4,4,14-trimethyl-11,15-dioxo-5-chol-8-en-24-oic acid)…”

Phytochemical investigation, antioxidant and anticholinesterase activities of Ganoderma adspersum

“…The basidiomycete genus Ganoderma belongs to the family Polyporaceae and is widely used as a traditional medicine in China, Korea, and Japan for hundreds of years (Lee et al, 2010). Ganoderma species are known to possess various biological activities.…”

Terpenoids with alpha-glucosidase inhibitory activity from the submerged culture of Inonotus obliquus

“…Compounds 1-4 are lanostane-type triterpenoids which have been frequently isolated from mushrooms, such as Ganoderma lucidum (Akihisa et al, 2005;Lee et al, 2010Lee et al, , 2011Tung et al, 2013) and Poria cocos (Kikuchi et al, 2011;Ukiya et al, 2002;Zhou et al, 2008). I. obliquus is also a proven and rich source of lanostane-type triterpenoids exemplified by the relatively abundant inotodiol (3) and 3b, 22-dihydroxyanosta-7, 9(11), 24-triene (4) (Handa et al, 2010;Liu et al, 2014).…”