upture of the anterior cruciate ligament is a common injury (incidence: 68.6 per 100 000 patient years) that mostly affects young, physically active patients and can lead to chronic instability (1). The lateral tibial plateau in particular is prone to anterior subluxation (anteroposterior instability), as the ligament no longer restricts movement and the axis of rotation can shift medially. Isolated injury to the posterior cruciate ligament is rarer (incidence: 1.8 per 100 000 patient years) (2). Chronic anteroposterior instability, which manifests in 8 to 50% of cases after surgical treatment and 75 to 87% after conservative treatment (3-7), is associated with increased risk of posttraumatic osteoarthritis of the knee (prevalence: 24.5 to 51.2%) (8), restricted knee function with reduced activity level (17% of competitive athletes do not return to competitive level) (9), and reduced quality of life (score of 54 to 77 on the KOOS QOL [Knee injury and Osteoarthritis Outcome Score: Quality of Life] versus 81 to 92 points in the uninjured population) (10). Despite intensive research into anterior cruciate ligament rupture, there is a lack of high-quality studies to determine clear treatment strategies for anterior cruciate ligament-deficient adults. According to the current S1 Guideline of the Association of Scientific Medical Societies in Germany (AWMF, Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften), anterior cruciate ligament reconstruction with autologous tendon graft is indicated for associated injuries to the collateral ligaments, meniscal injuries suitable for reconstruction, or a marked feeling of instability or subjective loading requirement. It is the first-line treatment for symptomatically unstable patients, in order to restore passive stability of the knee joint. According to meta-analyses and cohort studies, anterior cruciate ligament reconstruction can prevent secondary meniscal and cartilage injuries and restore previous activity levels (11-13). Until recently there was only one randomized controlled trial, though this was widely recognized, comparing outcomes following early surgery and following conservative treatment with optional delayed surgery. The findings of this trial indicate that nonsurgical treatment with possible delayed surgery leads to comparable subjective knee function and quality of life (14, 15). On the basis of these findings, coverage Summary Background: Anterior cruciate ligament (ACL) rupture is a serious injury in patients who are typically young and athletically active, with potential long-term complications including functional limitation, posttraumatic osteo arthritis of the knee, and impaired quality of life. ACL reconstruction is now considered the gold standard of treatment for regaining stability and improving knee function. Conservative treatment is an alternative. Methods: To compare operative and conservative treatment, we reviewed pertinent publications retrieved by a systematic search in Ovid MEDLINE, the Cochrane Database of Systematic...