Langzeitbeobachtung der therapiebedingten cranialen computertomographischen Veränderungen bei Kindern mit akuter lymphoblastischer Leukämie

Abstract

Corticoids can cause reversible signs of cerebral atrophy. In the assessment of CCTs a physiological age-dependence of the volume of the CSF compartment has to be taken into consideration. The main reason for non-reversible CCT changes is the CNS- prophylaxis, above all the cranial irradiation, whereby younger children seem to be particular vulnerable.