Language recovery following surgery and cns prophylaxis for the treatment of childhood medulloblastoma: A prospective study of three cases

Hudson, Lisa J; Murdoch, Bruce E.

doi:10.1080/02687039208248574

Cited by 16 publications

(13 citation statements)

References 29 publications

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“…Children with treated posterior fossa tumors (including MBs) show mild language impairment in auditory comprehension, oral expression, and textlevel language skills [11]. They can also have memory deficits [8], which may increase over time [4].…”

Section: Functional Domains Of Outcomementioning

confidence: 99%

Neuropsychological sequelae of the treatment of children with medulloblastoma

Dennis

et al. 1996

J Neuro-Oncol

167

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When a malignant tumor invades the child's cerebellum, the cost of successful treatment is often significant cognitive morbidity. A review of neuropsychological outcome revealed that survivors of childhood medulloblastoma (MB) have long-term deficits in intelligence, memory, language, attention, academic skills, psychosocial function, and a compromised quality of life. These deficits varied with chronological age at tumor diagnosis and/or adjuvant treatment, type and duration of presenting symptoms, tumor extension beyond the cerebellum, a history of adjuvant radiation treatment, and time since treatment. The effects on neuropsychological outcome of other factors, such as post-surgical hydrocephalus, were less clear. To understand the interaction between two factors predictive of outcome, age at diagnosis and time since treatment, we analyzed IQ results for a new sample of 25 surgically-treated and radiated MB survivors, and found that age at diagnosis and time since treatment made separable contributions to intellectual morbidity. PIQ appeared to measure some general effects of diffuse cerebral insult because it varied with chronological age of the child at tumor diagnosis but was relatively constant in magnitude, once established. VIQ, in contrast, was somewhat less sensitive to age at diagnosis in treated MB survivors, but declined with time since treatment. These results are important for understanding the academic attainments and continuing rehabilitation needs of childhood MB survivors, because they suggest that these children progressively fail to assimilate new verbally-based knowledge at a developmentally-appropriate rate.

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Section: Functional Domains Of Outcomementioning

confidence: 99%

Neuropsychological sequelae of the treatment of children with medulloblastoma

Dennis

et al. 1996

J Neuro-Oncol

167

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“…Reduced syntactic abilities, as well as intact naming skills and reading and writing abilities were also noted by these authors. Hudson and Murdoch (1992b) also documented language changes such as specific difficulties in listening and semantic tasks, word-finding, and some mildly reduced receptive language skills, in three children who had undergone both surgery and central nervous system radiation therapy for the treatment of a posterior fossa medulloblastoma. The considerable amount of variation in language abilities, including language impairment, was considered by these authors to be associated with the effects of the treatment over a 28 month post-treatment follow-up period.…”

Section: Specific Clinical Functions and Associated Clinical Changesmentioning

confidence: 95%

Cerebellar language and cognitive functions in childhood: A comparative review of the clinical research

2003

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Background: Recent research addressing evidence from functional neuroimaging studies, neurophysiological research, and new advances in neuropsychology together with traditional cerebellar lesion studies have recently implicated the cerebellum in adult language and cognitive functions. However, more limited information is currently available in describing the functional connectivity present in the paediatric population. Aims: It is the purpose of this paper to review recent clinical research pertaining to paediatric populations, outlining the impact of site of lesion and specific associated clinical changes in children with cerebellar disturbances. Main contribution: The specific contribution of the right cerebellar hemisphere to language function is identified to also exist in the paediatric population, highlighting the existence of functional connections between this region of the brain and left frontal cortical areas early in development.Conclusions: Implications for future research in paediatric populations are extensive, as a greater awareness and an understanding of the recently acknowledged involvement of the cerebellum in cognition and nonmotor linguistic function is anticipated to also add new dimension and direction to the analysis of childhood language outcomes associated with the cerebellum.

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“…Surprisingly, unlike neuropsychological effects that have been related to childhood radiation treatment of brain tumour, communication disorders have generally not been commonly linked to radiotherapy [6][7][8]26] . The one documented study that identified a possible connection reported language impairments inclusive of deficits in word finding, syntax and reading [8] .…”

Section: Discussion Of Casesmentioning

confidence: 99%

“…Subsequent to treatment, increasing evidence of intracranial changes may escalate over time, which in turn has the opportunity to impact language function to a greater extent [8,26,31] . The potential for even further decline is indicated by these preliminary results associated with increases in time subsequent to treatment completion reported by Hudson et al [8] .…”

Section: Discussion Of Casesmentioning

confidence: 99%

The Impact of a Cerebellar Tumour on Language Function in Childhood

Docking

Murdoch

Suppiah

2007

Folia Phoniatr Logop

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Background/Aims:Childhood-acquired cerebellar studies to date have appeared to present a concordant pattern of specific neuropsychological profiles depending on lesion site. The aim was to determine the impact of a cerebellar tumour specifically on language function in children by reporting both the general and high-level language abilities of 4 cases with differing sites of hemispheric and vermal involvement. Methods: The language abilities of 4 children (aged from 7 years 9 months to 13 years), treated with surgery and/or radiotherapy for cerebellar tumour 6 months to 3 years previously, were examined. A standardized battery of general and high-level language assessments was administered. Results: Analysis revealed intact abilities across all 4 cases on measures of general language, including receptive language, expressive language, receptive vocabulary and naming. While 2 of the 4 cases also demonstrated intact high-level language skills across all measures, the remaining 2 demonstrated specific deficits in linguistic problem solving at 6 months after treatment. Follow-up assessment of 1 case also demonstrated further decline in this area 12 months later. Conclusion: Findings of high-level language deficits in problem solving in 2 of the 4 cases examined supported previous reports of specific impairments in high-level language and in thinking flexibility and problem solving following cerebellar hemispheric damage in childhood.

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Language recovery following surgery and cns prophylaxis for the treatment of childhood medulloblastoma: A prospective study of three cases

Cited by 16 publications

References 29 publications

Neuropsychological sequelae of the treatment of children with medulloblastoma

Neuropsychological sequelae of the treatment of children with medulloblastoma

Cerebellar language and cognitive functions in childhood: A comparative review of the clinical research

The Impact of a Cerebellar Tumour on Language Function in Childhood

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