Language processing in glioma patients: speed or accuracy as a sensitive measure?

Mooijman, Saskia; Bos, Laura S.; Witte, Elke De; Vincent, Arnaud; Visch-Brink, Evy; Satoer, Djaina

doi:10.1080/02687038.2021.1970099

Cited by 7 publications

(4 citation statements)

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“…Second, tumor in the right hemisphere was more often observed in the musical group which could be a confounding on language performance, considering that language is often lateralized in the left hemisphere. However, we argue that this does not influence our results as prior research found that hemispheric lateralization does not affect language performance on the DIMA scale in glioma patients (Mooijman et al, 2021;Satoer et al, 2022).…”

Section: Strengths and Limitationscontrasting

confidence: 45%

The effect of musicality on language recovery after awake glioma surgery

Kappen

Brink

Jeekel

et al. 2023

Front. Hum. Neurosci.

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IntroductionAwake craniotomy is increasingly used to resect intrinsic brain tumors while preserving language. The level of musical training might affect the speed and extend of postoperative language recovery, as increased white matter connectivity in the corpus callosum is described in musicians compared to non-musicians.MethodsIn this cohort study, we included adult patients undergoing treatment for glioma with an awake resection procedure at two neurosurgical centers and assessed language preoperatively (T1) and postoperatively at three months (T2) and one year (T3) with the Diagnostic Instrument for Mild Aphasia (DIMA), transferred to z-scores. Moreover, patients’ musicality was divided into three groups based on the Musical Expertise Criterion (MEC) and automated volumetric measures of the corpus callosum were conducted.ResultsWe enrolled forty-six patients, between June 2015 and September 2021, and divided in: group A (non-musicians, n = 19, 41.3%), group B (amateur musicians, n = 17, 36.9%) and group C (trained musicians, n = 10, 21.7%). No significant differences on postoperative language course between the three musicality groups were observed in the main analyses. However, a trend towards less deterioration of language (mean/SD z-scores) was observed within the first three months on the phonological domain (A: −0.425/0.951 vs. B: −0.00100/1.14 vs. C: 0.0289/0.566, p-value = 0.19) with a significant effect between non-musicians vs. instrumentalists (A: −0.425/0.951 vs. B + C: 0.201/0.699, p = 0.04). Moreover, a non-significant trend towards a larger volume (mean/SD cm3) of the corpus callosum was observed between the three musicality groups (A: 6.67/1.35 vs. B: 7.09/1.07 vs. C: 8.30/2.30, p = 0.13), with the largest difference of size in the anterior corpus callosum in non-musicians compared to trained musicians (A: 3.28/0.621 vs. C: 4.90/1.41, p = 0.02).ConclusionWith first study on this topic, we support that musicality contributes to language recovery after awake glioma surgery, possibly attributed to a higher white matter connectivity at the anterior part of the corpus callosum. Our conclusion should be handled with caution and interpreted as hypothesis generating only, as most of our results were not significant. Future studies with larger sample sizes are needed to confirm our hypothesis.

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Section: Strengths and Limitationscontrasting

confidence: 45%

The effect of musicality on language recovery after awake glioma surgery

Kappen

Brink

Jeekel

et al. 2023

Front. Hum. Neurosci.

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“…In recent years, the language abilities of people with brain tumours have received much attention (Mooijman et al, 2021; Rofes, Mandonnet, et al, 2017; Satoer et al, 2013). Tasks and assessments at the sentence and at the word level have been employed.…”

Section: Introductionmentioning

confidence: 99%

“…Satoer et al (2013) reported that during preoperative spontaneous speech individuals with brain tumours produced more incomplete sentences and had shorter mean length of utterance than a matched control group. However, even though people with brain tumours report word finding problems, single‐word object naming tasks are not always sensitive enough to detect any preoperative difficulties (Mooijman et al, 2021). More importantly, the numbers of patients that are classified as ‘impaired’ seem to differ according to the linguistic modality and the linguistic stimuli used in each neurosurgical centre.…”

Section: Introductionmentioning

confidence: 99%

Lesion‐symptom mapping of language impairments in people with brain tumours: The influence of linguistic stimuli

Ntemou

Rybka

Lubbers

et al. 2023

Journal of Neuropsychology

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People with tumours in specific brain sites might face difficulties in tasks with different linguistic material. Previous lesion-symptom mapping studies (VLSM) demonstrated that people with tumours in posterior temporal regions have more severe linguistic impairments. However, to the best of our knowledge, preoperative performance and lesion location on tasks with different linguistic stimuli have not been examined. In the present study, we performed VLSM on 52 people with left gliomas to examine whether tumour distribution differs depending on the tasks of the Aachen Aphasia Test. The VLSM analysis revealed that single-word production (e.g. object naming) was associated with the inferior parietal lobe and that compound and sentence production were additionally associated with posterior temporal gyri. Word repetition was affected in people with tumours in inferior parietal areas, whereas sentence repetition was the only task to be associated with frontal regions. Subcortically, word and sentence production were found to be affected in people with tumours reaching the arcuate fasciculus, and compound production was primarily associated with tumours affecting the inferior longitudinal and inferior fronto-occipital fasciculus. Our work shows that tasks with linguistic stimuli other than single-word naming (e.g. compound and sentence production) relate to additional cortical and subcortical brain areas. At a clinical level, we show that tasks that target the same processes (e.g. repetition) can have different neural correlates depending on

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“…However, the outcomes can assist selection of variables in future studies. Language domains that appear most promising in relation to FC networks are word retrieval (as assessed with object naming), grammar, and comprehension of visual input when using a sufficiently sensitive test (e.g., combination of accuracy and speed, Mooijman et al, 2021 ) and to a lesser extent semantics and writing. FC network characteristics that appear most promising in relation to language functioning are MST degree, eccentricity and diameter in the theta band, and weighted small-world index in the alpha band.…”

Section: Discussionmentioning

confidence: 99%

Resting-State Electroencephalography Functional Connectivity Networks Relate to Pre- and Postoperative Language Functioning in Low-Grade Glioma and Meningioma Patients

et al. 2021

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Introduction: Preservation of language functioning in patients undergoing brain tumor surgery is essential because language impairments negatively impact the quality of life. Brain tumor patients have alterations in functional connectivity (FC), the extent to which brain areas functionally interact. We studied FC networks in relation to language functioning in glioma and meningioma patients.Method: Patients with a low-grade glioma (N = 15) or meningioma (N = 10) infiltrating into/pressing on the language-dominant hemisphere underwent extensive language testing before and 1 year after surgery. Resting-state EEG was registered preoperatively, postoperatively (glioma patients only), and once in healthy individuals. After analyzing FC in theta and alpha frequency bands, weighted networks and Minimum Spanning Trees were quantified by various network measures.Results: Pre-operative FC network characteristics did not differ between glioma patients and healthy individuals. However, hub presence and higher local and global FC are associated with poorer language functioning before surgery in glioma patients and predict worse language performance at 1 year after surgery. For meningioma patients, a greater small worldness was related to worse language performance and hub presence; better average clustering and global integration were predictive of worse outcome on language function 1 year after surgery. The average eccentricity, diameter and tree hierarchy seem to be the network metrics with the more pronounced relation to language performance.Discussion: In this exploratory study, we demonstrated that preoperative FC networks are informative for pre- and postoperative language functioning in glioma patients and to a lesser extent in meningioma patients.

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Language processing in glioma patients: speed or accuracy as a sensitive measure?

Cited by 7 publications

References 50 publications

The effect of musicality on language recovery after awake glioma surgery

The effect of musicality on language recovery after awake glioma surgery

Lesion‐symptom mapping of language impairments in people with brain tumours: The influence of linguistic stimuli

Resting-State Electroencephalography Functional Connectivity Networks Relate to Pre- and Postoperative Language Functioning in Low-Grade Glioma and Meningioma Patients

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