Language outcomes among ELBW infants in early childhood

Adams‐Chapman, Ira; Bann, Carla; Carter, Sheena L.; Stoll, Barbara J.

doi:10.1016/j.earlhumdev.2015.03.011

Cited by 52 publications

(42 citation statements)

References 38 publications

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“…The primary behavioral outcomes were ADOS scores and language assessed by standardized vocabulary testing. Expressive vocabulary was assessed by Expressive One‐Word Picture Vocabulary Test (EOWPVT) 37. Primary outcomes were measured at baseline, and 2 days and 6 weeks after infusion.…”

Section: Methodsmentioning

confidence: 99%

Low‐dose suramin in autism spectrum disorder: a small, phase I/II, randomized clinical trial

Naviaux

Curtis

et al. 2017

Ann Clin Transl Neurol

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ObjectiveNo drug is yet approved to treat the core symptoms of autism spectrum disorder (ASD). Low‐dose suramin was effective in the maternal immune activation and Fragile X mouse models of ASD. The Suramin Autism Treatment‐1 (SAT‐1) trial was a double‐blind, placebo‐controlled, translational pilot study to examine the safety and activity of low‐dose suramin in children with ASD.MethodsTen male subjects with ASD, ages 5–14 years, were matched by age, IQ, and autism severity into five pairs, then randomized to receive a single, intravenous infusion of suramin (20 mg/kg) or saline. The primary outcomes were ADOS‐2 comparison scores and Expressive One‐Word Picture Vocabulary Test (EOWPVT). Secondary outcomes were the aberrant behavior checklist, autism treatment evaluation checklist, repetitive behavior questionnaire, and clinical global impression questionnaire.ResultsBlood levels of suramin were 12 ± 1.5 μmol/L (mean ± SD) at 2 days and 1.5 ± 0.5 μmol/L after 6 weeks. The terminal half‐life was 14.7 ± 0.7 days. A self‐limited, asymptomatic rash was seen, but there were no serious adverse events. ADOS‐2 comparison scores improved by −1.6 ± 0.55 points (n = 5; 95% CI = −2.3 to −0.9; Cohen's d = 2.9; P = 0.0028) in the suramin group and did not change in the placebo group. EOWPVT scores did not change. Secondary outcomes also showed improvements in language, social interaction, and decreased restricted or repetitive behaviors.InterpretationThe safety and activity of low‐dose suramin showed promise as a novel approach to treatment of ASD in this small study.

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Section: Methodsmentioning

confidence: 99%

Low‐dose suramin in autism spectrum disorder: a small, phase I/II, randomized clinical trial

Naviaux

Curtis

et al. 2017

Ann Clin Transl Neurol

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“…Children born extremely preterm are at risk for a variety of developmental problems, including cognitive delay [1], language disorders [2], and behavioral problems [3]. Early developmental difficulties continue into school age, where children born extremely preterm have higher risks of learning disabilities and behavioral disorders [4].…”

Section: Introductionmentioning

confidence: 99%

Behavioral problems are associated with cognitive and language scores in toddlers born extremely preterm

Lowe

Fuller

Tiddi

et al. 2019

Early Human Development

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Objective: To evaluate the relationship of parent-reported child behaviors on the Child Behavior Checklist (CBCL) to cognition, language, and motor skills on the Bayley Scales of Infant and Toddler Development – III (Bayley-III) in toddlers born extremely preterm. Study Design: Toddlers born extremely preterm (gestational ages 22 0/7 to 26 6/7 weeks) were tested at 22 – 26 months corrected age with Bayley-III while parents completed the CBCL. Socio-demographic variables and medical history were recorded. Linear regression models were used to assess the relationship of Bayley-III cognitive, motor, and language scores with CBCL scores, adjusting for medical and socio-demographic factors. Results: Internalizing, affective, and pervasive development problem behavior scores on the CBCL correlated significantly with lower Bayley-III cognitive, language, and motor scores on unadjusted and adjusted analyses. Although externalizing and anxiety problems were significantly associated with cognitive and language scores on unadjusted analysis, the relationships were not significant after adjusting for socio-economic factors. CBCL scores were similar for boys and girls, with the exception of the pervasive developmental problem scale; boys had significantly more problems than girls (p=0.02). Conclusions: This study showed that parent reported behavior problems were related to lower cognitive, language, and motor development in toddlers born extremely preterm. Early findings of behavioral problems in toddlers born extremely premature may help identify children at greater risk for later learning difficulties. Adding a measure of behavior to the evaluation of these children may help better understand factors that can contribute to delays, especially in cognition and language.

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“…VPT children obtain, on average, standardized full scale intelligence quotient (FSIQ) scores 10 points below FT children (Kerr-Wilson, Mackay, Smith, & Pell, 2012). Language delays have been reported as early age 24 months in VPT infants, with problems persisting to preschool and school age (Adams-Chapman, Bann, Carter, & Stoll, 2015; Barre, Morgan, Doyle, & Anderson, 2011). Importantly, VPT birth increases risks of intellectual and language impairment after accounting for sociofamilial background (Pritchard, Bora, Austin, Levin, & Woodward, 2014).…”

Section: Introductionmentioning

confidence: 99%

Maternal intelligence quotient (IQ) predicts IQ and language in very preterm children at age 5 years

Lean

Paul

Smyser

et al. 2017

Child Psychology Psychiatry

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Maternal intellectual ability is an important trait linked to VPT and FT children's intellectual and language outcomes. Prematurity increases variation in the heritability of intellectual ability and shifts children from the expected range based on maternal ability. Parental involvement in activities that help children master new skills may promote cognitive development in VPT children born to mothers of lower intellectual ability.

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Language outcomes among ELBW infants in early childhood

Abstract: Background-Limited data are available evaluating language outcomes of preterm infants in early childhood. Furthermore, the relationship between language outcomes, medical morbidities and developmental trajectory in early infancy is unclear.

Cited by 52 publications

References 38 publications

Low‐dose suramin in autism spectrum disorder: a small, phase I/II, randomized clinical trial

Low‐dose suramin in autism spectrum disorder: a small, phase I/II, randomized clinical trial

Behavioral problems are associated with cognitive and language scores in toddlers born extremely preterm

Maternal intelligence quotient (IQ) predicts IQ and language in very preterm children at age 5 years

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