Language, motor and speed of processing deficits in adolescents with subclinical psychotic symptoms

Blanchard, Mathieu; Jacobson, Sarah; Clarke, Mary; Connor, Dearbhla; Kelleher, Ian; Garavan, Hugh; Harley, Michelle; Cannon, Mary

doi:10.1016/j.schres.2010.05.028

Cited by 83 publications

(67 citation statements)

References 34 publications

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“…In particular, deficits in processing speed have been found pronounced in this group. Blanchard and colleagues, 156 for example, showed that, in addition to poorer scores in tests of receptive language and motor skills, young people with psychotic symptoms performed more poorly on the Trail Making Test, Part B. This is in line with a previous cohort study, which demonstrated that childhood performance on this task predicted schizophrenia in adulthood.…”

Section: The Community Approachsupporting

confidence: 59%

Predicting Risk and the Emergence of Schizophrenia

Clarke

Kelleher

Clancy

et al. 2012

Psychiatric Clinics of North America

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Section: The Community Approachsupporting

confidence: 59%

Predicting Risk and the Emergence of Schizophrenia

Clarke

Kelleher

Clancy

et al. 2012

Psychiatric Clinics of North America

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“…However, repeating the analyses while controlling for co-morbidity showed that the results did not change (in effect sizes or in significance), indicating that co-morbidity was not a confounder in the association between depression and subclinical psychosis. Another mechanistic explanation to consider is that individuals with psychotic experiences may have higher levels of neurocognitive alterations and negative symptoms (Simons et al 2007;Blanchard et al 2010;Kelleher et al 2012a). Alterations in these domains may reduce the ability to engage in or to benefit from psychological therapies.…”

Section: Discussionmentioning

confidence: 99%

Subclinical psychotic experiences and bipolar spectrum features in depression: association with outcome of psychotherapy

Wigman

Abidi

et al. 2013

Psychol. Med.

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Background. Subthreshold psychotic and bipolar experiences are common in major depressive disorder (MDD). However, it is unknown if effectiveness of psychotherapy is altered in depressed patients who display such features compared with those without. The current paper aimed to investigate the impact of the co-presence of subclinical psychotic experiences and subclinical bipolar symptoms on the effectiveness of psychological treatment, alone or in combination with pharmacotherapy.Method. In a naturalistic study, patients with MDD (n = 116) received psychological treatment (cognitive behavioural therapy or interpersonal psychotherapy) alone or in combination with pharmacotherapy. Depression and functioning were assessed six times over 2 years. Lifetime psychotic experiences and bipolar symptoms were assessed at the second time point.Results. Subclinical psychotic experiences predicted more depression over time (β = 0.20, p < 0.002), non-remission [odds ratio (OR) 7.51, p < 0.016] and relapse (OR 3.85, p < 0.034). Subthreshold bipolar symptoms predicted relapse (OR 1.16, p < 0.037).Conclusions. In general, subclinical psychotic experiences have a negative impact on the course and outcome of psychotherapy in MDD. Effects of subclinical bipolar experiences were less prominent.

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“…Neurocognitive deficits have been reported in individuals with psychotic experiences, most notably in processing speed (Barnett et al, 2012;Blanchard et al, 2010;Cullen et al, 2010;Kelleher et al, 2012a), a domain that has previously been highlighted as important more generally in terms of social/role functioning (Carrion et al, 2011). Furthermore, individuals with psychotic experiences have been shown to have significantly more exposure to childhood trauma (Arseneault et al, 2011;Fisher et al, 2012;Freeman and Fowler, 2009;Galletly et al, 2011;Janssen et al, 2004;Kelleher et al, 2013c;Saha et al, 2011b;Scott et al, 2007;Wigman et al, 2012b), something that might also contribute to long term dysfunction.…”

Section: Introductionmentioning

confidence: 99%