Language lateralization development in children with autism: Insights from the late field magnetoencephalogram

Flagg, Elissa J.; Cardy, Janis Oram; Roberts, Wendy; Roberts, Timothy P. L.

doi:10.1016/j.neulet.2005.05.037

Cited by 122 publications

(115 citation statements)

References 33 publications

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“…Our finding that the subjects with autism are less able to detect speech features when the task is manipulated in the temporal domain points to deficient left-hemisphere processing. This is in line with converging evidence from structural, ERP and MEG studies that point to other left hemisphere deficits in autism as well (Bruneau et al 2003;Lepisto et al 2006;Flagg et al 2005;Wilson et al 2006;Murias et al 2007) Compared with the pink noise condition, the ripple signal separation task was extended significantly in the spectral domain (see Methods section), which required additional right hemisphere involvement. The higher detection thresholds in this condition suggest that resolving the spectral components was the main bottleneck to perform the task, and equally so in both subject groups.…”

Section: Discussionsupporting

confidence: 84%

Intact Spectral but Abnormal Temporal Processing of Auditory Stimuli in Autism

Groen

Orsouw

Huurne

et al. 2009

J Autism Dev Disord

105

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The perceptual pattern in autism has been related to either a specific localized processing deficit or a pathway-independent, complexity-specific anomaly. We examined auditory perception in autism using an auditory disembedding task that required spectral and temporal integration. 23 children with high-functioning-autism and 23 matched controls participated. Participants were presented with two-syllable words embedded in various auditory backgrounds (pink noise, moving ripple, amplitude-modulated pink noise, amplitude-modulated moving ripple) to assess speech-in-noise-reception thresholds. The gain in signal perception of pink noise with temporal dips relative to pink noise without temporal dips was smaller in children with autism (p = 0.008). Thus, the autism group was less able to integrate auditory information present in temporal dips in background sound, supporting the complexity-specific perceptual account.

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Section: Discussionsupporting

confidence: 84%

Intact Spectral but Abnormal Temporal Processing of Auditory Stimuli in Autism

Groen

Orsouw

Huurne

et al. 2009

J Autism Dev Disord

105

View full text Add to dashboard Cite

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“…In this regard, a number of electrophysiological and neuroimaging studies reported right hemisphere dominance of auditory processing and speech perception in individuals with ASD, while controls showed left hemisphere dominance (e.g., Boddaert et al 2003;Bruneau et al 1999;Eyler et al 2012;Flagg et al 2005;Müller et al 1998Müller et al , 1999Redcay and Courchesne 2008;Roberts et al 2008; but see Whitehouse and Bishop 2008). Flagg et al (2005), in particular, observed a reversed maturational pattern of lateralization: Whereas controls matured from bilateral activation to left hemisphere dominance in the processing of speech sounds, children with autism matured towards right hemisphere dominance.…”

Section: Introductionmentioning

confidence: 99%

Fragile Spectral and Temporal Auditory Processing in Adolescents with Autism Spectrum Disorder and Early Language Delay

Boets

Verhoeven

Wouters

et al. 2014

J Autism Dev Disord

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We investigated low-level auditory spectral and temporal processing in adolescents with autism spectrum disorder (ASD) and early language delay compared to matched typically developing controls. Auditory measures were designed to target right versus left auditory cortex processing (i.e. frequency discrimination and slow amplitude modulation (AM) detection versus gap-in-noise detection and faster AM detection), and to pinpoint the task and stimulus characteristics underlying putative superior spectral processing in ASD. We observed impaired frequency discrimination in the ASD group and suggestive evidence of poorer temporal resolution as indexed by gapin-noise detection thresholds. These findings question the evidence of enhanced spectral sensitivity in ASD and do not support the hypothesis of superior right and inferior left hemispheric auditory processing in ASD.

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“…Structural and functional neuroimaging studies of language areas have provided evidence that differences in lateralization may underlie language and communication difficulties in individuals with ASD (Bigler et al, 2007;Boddaert et al, 2003;Chandana et al, 2005;Chiron et al, 1995;Flagg et al, 2005;Herbert et al, 2002;. For example, a series of volumetric studies by Herbert and colleagues (Herbert et al, 2002;, demonstrated that brain asymmetry patterns differed in children with high functioning autism compared to controls.…”

Section: Introductionmentioning

confidence: 99%

Atypical functional lateralization of language in autism spectrum disorders

et al. 2008

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Impaired language is a prominent behavioral marker of autism spectrum disorders (ASD), but its neurobiological underpinnings are incompletely understood. We studied letter and category fluency in 14 high functioning ASD individuals and 14 age-matched controls. Each fluency condition was compared to self-paced repetition of the word "nothing." Responses were recorded to monitor performance. In letter fluency, the ASD group had significantly greater activation than controls in the right frontal and right superior temporal lobe. Between-group differences were not observed in left prefrontal cortex. By examining functional asymmetry in frontal cortex, we found that the ASD group had significantly reduced lateralization of activation patterns in letter fluency compared to the controls. In category fluency, no between-group differences in lateralization were found, in light of greater bilateral activation in controls. These findings indicate reduced hemispheric differentiation for certain verbal fluency tasks in ASD, consistent with some previous evidence of atypical functional and structural asymmetries in autism. Abnormal functional organization may contribute to the language impairment seen in ASD.

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Language lateralization development in children with autism: Insights from the late field magnetoencephalogram

Cited by 122 publications

References 33 publications

Intact Spectral but Abnormal Temporal Processing of Auditory Stimuli in Autism

Intact Spectral but Abnormal Temporal Processing of Auditory Stimuli in Autism

Fragile Spectral and Temporal Auditory Processing in Adolescents with Autism Spectrum Disorder and Early Language Delay

Atypical functional lateralization of language in autism spectrum disorders

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