Language Impairment in Vascular Dementia: A Clinical Review

Macoir, Joël

doi:10.1177/08919887231195225

Cited by 2 publications

(3 citation statements)

References 87 publications

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“…As the disease progresses and deficits multiply, other cognitive functions are gradually impaired, including language function. 43 Thus, this provides further support for the existing connectivity between the LN and ECN. Moreover, the causal relationship between executive function and language function to some extent explains the asynchrony in the results of intra-ECN and intra-LN FC after computerized cognitive training.…”

Section: Alterations Of the Language Networksupporting

confidence: 59%

“…Language deficits are a significant clinical feature of VCIND, 43 and lower parietal lobules, areas that are involved in functions related to language comprehension, language expression, and speech processing. T2 and T3 are located in the brain's temporal lobe and are closely associated with language comprehension and semantic processing.…”

Section: Alterations Of the Language Networkmentioning

confidence: 99%

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Effects of computerized cognitive training on functional brain networks in patients with vascular cognitive impairment and no dementia

Li,

Xing,

Zhu

et al. 2024

CNS Neurosci Ther

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AimsPrevious neuroimaging studies of vascular cognitive impairment, no dementia (VCIND), have reported functional alterations, but far less is known about the effects of cognitive training on functional connectivity (FC) of intrinsic connectivity networks (ICNs) and how they relate to intervention‐related cognitive improvement. This study provides comprehensive research on the changes in intra‐ and inter‐brain functional networks in patients with VCIND who received computerized cognitive training, with a focus on the underlying mechanisms and potential therapeutic strategies.MethodsWe prospectively collected 60 patients with VCIND who were randomly divided into the training group (N = 30) receiving computerized cognitive training and the control group (N = 30) receiving fixed cognitive training. Functional MRI scans and cognitive assessments were performed at baseline, at the 7‐week training, and at the 6‐month follow‐up. Utilizing templates for ICNs, the study employed a linear mixed model to compare intra‐ and inter‐network FC changes between the two groups. Pearson correlation was applied to calculate the relationship between FC and cognitive function.ResultsWe found significantly decreased intra‐network FC within the default mode network (DMN) following computerized cognitive training at Month 6 (p = 0.034), suggesting a potential loss of functional specialization. Computerized training led to increased functional coupling between the DMN and sensorimotor network (SMN) (p = 0.01) and between the language network (LN) and executive control network (ECN) at Month 6 (p < 0.001), indicating compensatory network adaptations in patients with VCIND. Notably, the intra‐LN exhibited enhanced functional specialization after computerized cognitive training (p = 0.049), with significant FC increases among LN regions, which correlated with improvements in neuropsychological measures (p < 0.05), emphasizing the targeted impact of computerized cognitive training on language abilities.ConclusionsThis study provides insights into neuroplasticity and adaptive changes resulting from cognitive training in patients with VCIND, with implications for potential therapeutic strategies.

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Section: Alterations Of the Language Networksupporting

confidence: 59%

Section: Alterations Of the Language Networkmentioning

confidence: 99%

Effects of computerized cognitive training on functional brain networks in patients with vascular cognitive impairment and no dementia

Li,

Xing,

Zhu

et al. 2024

CNS Neurosci Ther

View full text Add to dashboard Cite

show abstract

“…Impairments in this area, while uncommon, can vary greatly depending on the type, extent, location, and severity of CVD [153].…”

Section: Languagementioning

confidence: 99%

Neuropsychological Assessment for Early Detection and Diagnosis of Dementia: Current Knowledge and New Insights

Alzola,

Carnero,

Bermejo-Pareja

et al. 2024

JCM

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Dementia remains an underdiagnosed syndrome, and there is a need to improve the early detection of cognitive decline. This narrative review examines the role of neuropsychological assessment in the characterization of cognitive changes associated with dementia syndrome at different states. The first section describes the early indicators of cognitive decline and the major barriers to their identification. Further, the optimal cognitive screening conditions and the most widely accepted tests are described. The second section analyzes the main differences in cognitive performance between Alzheimer’s disease and other subtypes of dementia. Finally, the current challenges of neuropsychological assessment in aging/dementia and future approaches are discussed. Essentially, we find that current research is beginning to uncover early cognitive changes that precede dementia, while continuing to improve and refine the differential diagnosis of neurodegenerative disorders that cause dementia. However, neuropsychology faces several barriers, including the cultural diversity of the populations, a limited implementation in public health systems, and the adaptation to technological advances. Nowadays, neuropsychological assessment plays a fundamental role in characterizing cognitive decline in the different stages of dementia, but more efforts are needed to develop harmonized procedures that facilitate its use in different clinical contexts and research protocols.

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Language Impairment in Vascular Dementia: A Clinical Review

Cited by 2 publications

References 87 publications

Effects of computerized cognitive training on functional brain networks in patients with vascular cognitive impairment and no dementia

Effects of computerized cognitive training on functional brain networks in patients with vascular cognitive impairment and no dementia

Neuropsychological Assessment for Early Detection and Diagnosis of Dementia: Current Knowledge and New Insights

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