Language impairment in primary progressive aphasia and other neurodegenerative diseases

Rahul, D. R.; Ponniah, R. Joseph

doi:10.1007/s12041-019-1139-5

Cited by 7 publications

(10 citation statements)

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“…Several studies have demonstrated effectiveness of intervention approaches in improving naming difficulties in PPAs [12,17,22,24,25,[55][56][57][58][59][60], supporting both crucial roles of early intervention and the possibility of inducing generalization and long-term maintenance of gains [21,56,61,62].…”

Section: Naming Treatment In Ppamentioning

confidence: 93%

“…The svPPA is clinically characterized by a slow loss of semantic knowledge [7], anomia, and single-word comprehension deficits, especially for low-frequency items [6,7,12]. The impairment in single-word comprehension is usually the earliest symptom of semantic memory deficit, subsequently leading to deterioration in recognizing objects and people [13].…”

Section: Introductionmentioning

confidence: 99%

“…The impairment in single-word comprehension is usually the earliest symptom of semantic memory deficit, subsequently leading to deterioration in recognizing objects and people [13]. Patients with svPPA are fluent in spontaneous speech and word repetition is spared, although they can exhibit surface dyslexia and dysgraphia [3,6,12]. The neuroanatomical profiles of svPPA include bilateral, although mainly left-lateralized, anterior inferior and mesial temporal lobe atrophy [13].…”

Section: Introductionmentioning

confidence: 99%

“…In a substantial number of patients with PPA, the disease arises at middle age and has a devastating effect on their quality of life [17]. Moreover, language impairment in PPAs is the main stressor for patients and their caregivers, which causes serious impacts on patient relationships, social networks, and the possibility of participating in a large number of everyday activities based on communication [12,18].…”

Section: Introductionmentioning

confidence: 99%

“…In the absence of effective pharmacological therapies to improve or stabilize the cognitive-linguistic deficits, there has been an increased interest in language training interventions to minimize the functional impact of communication difficulties in daily life and remediate language deficits in PPAs [13,17,19,20]. Currently, different interventions have been described for individuals with PPA [12,17,21,22].…”

Section: Introductionmentioning

confidence: 99%

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Language training for oral and written naming impairment in primary progressive aphasia: a review

Pagnoni

Gobbi

Premi

et al. 2021

Transl Neurodegener

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Background Primary progressive aphasia (PPA) is a neurodegenerative disorder characterized by a gradual, insidious and progressive loss of language abilities, with naming difficulties being an early and persistent impairment common to all three variants. In the absence of effective pharmacological treatments and given the progressive nature of the disorder, in the past few decades, many studies have investigated the effectiveness of language training to minimize the functional impact of word-finding difficulties in daily life. Main body We review language treatments most commonly used in clinical practice among patients with different variants of PPA, with a focus on the enhancement of spoken and written naming abilities. Generalization of gains to the ability to name untrained stimuli or to other language abilities and the maintenance of these results over time are also discussed. Forty-eight studies were included in this literature review, identifying four main types of language treatment: a) lexical retrieval treatment, b) phonological and/or orthographic treatment, c) semantic treatment, and d) a multimodality approach treatment. Overall, language training is able to induce immediate improvements of naming abilities in all variants of PPA. Moreover, despite the large variability among results, generalization and long-term effects can be recorded after the training. The reviewed studies also suggest that one factor that determines the choice of a particular approach is the compromised components of the lexical/semantic processing system. Conclusion The majority of studies have demonstrated improvements of naming abilities following language treatments. Given the progressive nature of PPA, it is essential to apply language treatment in the early stages of the disease.

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Section: Naming Treatment In Ppamentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Language training for oral and written naming impairment in primary progressive aphasia: a review

Pagnoni

Gobbi

Premi

et al. 2021

Transl Neurodegener

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Bridging the gap between scientific research of rare diseases and the affected patients and families

Lannom

2024

Journal of Communication in Healthcare

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Natural language processing techniques for studying language in pathological ageing: A scoping review

Gagliardi

2023

Intl J Lang & Comm Disor

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BackgroundIn the past few years there has been a growing interest in the employment of verbal productions as digital biomarkers, namely objective, quantifiable behavioural data that can be collected and measured by means of digital devices, allowing for a low‐cost pathology detection, classification and monitoring. Numerous research papers have been published on the automatic detection of subtle verbal alteration, starting from written texts, raw speech recordings and transcripts, and such linguistic analysis has been singled out as a cost‐effective method for diagnosing dementia and other medical conditions common among elderly patients (e.g., cognitive dysfunctions associated with metabolic disorders, dysarthria).AimsTo provide a critical appraisal and synthesis of evidence concerning the application of natural language processing (NLP) techniques for clinical purposes in the geriatric population. In particular, we discuss the state of the art on studying language in healthy and pathological ageing, focusing on the latest research efforts to build non‐intrusive language‐based tools for the early identification of cognitive frailty due to dementia. We also discuss some challenges and open problems raised by this approach.Methods & ProceduresWe performed a scoping review to examine emerging evidence about this novel domain. Potentially relevant studies published up to November 2021 were identified from the databases of MEDLINE, Cochrane and Web of Science. We also browsed the proceedings of leading international conferences (e.g., ACL, COLING, Interspeech, LREC) from 2017 to 2021, and checked the reference lists of relevant studies and reviews.Main ContributionThe paper provides an introductory, but complete, overview of the application of NLP techniques for studying language disruption due to dementia. We also suggest that this technique can be fruitfully applied to other medical conditions (e.g., cognitive dysfunctions associated with dysarthria, cerebrovascular disease and mood disorders).Conclusions & ImplicationsDespite several critical points need to be addressed by the scientific community, a growing body of empirical evidence shows that NLP techniques can represent a promising tool for studying language changes in pathological aging, with a high potential to lead a significant shift in clinical practice.WHAT THIS PAPER ADDSWhat is already known on this subject Speech and languages abilities change due to non‐pathological neurocognitive ageing and neurodegenerative processes. These subtle verbal modifications can be measured through NLP techniques and used as biomarkers for screening/diagnostic purposes in the geriatric population (i.e., digital linguistic biomarkers—DLBs).What this paper adds to existing knowledge The review shows that DLBs can represent a promising clinical tool, with a high potential to spark a major shift to dementia assessment in the elderly. Some challenges and open problems are also discussed.What are the potential or actual clinical implications of this work? This methodological review represents a starting point for clinicians approaching the DLB research field for studying language in healthy and pathological ageing. It summarizes the state of the art and future research directions of this novel approach.

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Language impairment in primary progressive aphasia and other neurodegenerative diseases

Cited by 7 publications

References 94 publications

Language training for oral and written naming impairment in primary progressive aphasia: a review

Language training for oral and written naming impairment in primary progressive aphasia: a review

Bridging the gap between scientific research of rare diseases and the affected patients and families

Natural language processing techniques for studying language in pathological ageing: A scoping review

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