Language impairment in Parkinson’s disease: fMRI study of sentence reading comprehension

Novakova, Lubomira; Gajdoš, Martin; Marková, Jana; Martinkovicova, Alice; Košutzká, Zuzana; Svantnerova, Jana; Valkovič, Peter; Cséfalvay, Zsolt; Rektorová, Irena

doi:10.3389/fnagi.2023.1117473

Cited by 3 publications

(1 citation statement)

References 45 publications

(73 reference statements)

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“…A voxel threshold of 0.001 was again applied. Where trends were observed, we explored these with a 0.005 threshold, which is commonly applied in psychophysiological interaction analyses 80,81 . We additionally compared the 3B and 2B conditions to evaluate whether connectivity differences involved similar locations when only the cognitive load was increased, without involving prospective memory.…”

Section: Methodsmentioning

confidence: 99%

Exploring anterior thalamus functional connectivity with cortical regions in prospective memory with ultra-high-field fMRI

Flanagan,

Mansur,

Reichert

et al. 2024

Preprint

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Introduction Prospective memory (PM), or memory for future intentions, engages particular cortical regions. Lesion studies also implicate the thalamus, with PM deterioration following thalamic stroke. Neuroimaging, anatomical, and lesion studies suggest the anterior nuclei of the thalamus (ANT) in particular are involved in episodic memory processing, with electrophysiological studies providing evidence for an active role in selection of neural assemblies underlying particular memory traces. Here we hypothesized that the ANT are also engaged in realizing prospectively-encoded intentions. Methods Participants (N = 14) performed an n-back working memory task as the ongoing task (OGT) with two cognitive loads, each with and without a PM component, during 7-Tesla functional magnetic resonance imaging. Seed-to-voxel whole brain functional connectivity analyses were performed to establish whether including a PM component in an OGT results in greater connectivity between ANT and cortical regions known to be engaged in PM. Repeated measures ANOVAs were applied to behavioral and connectivity measures, with the factors Task Type (with PM or not) and N-Back (2-back or 3-back). Results Response accuracy was greater and reaction times faster without the PM component, and accuracy was higher in the 2- than 3-back condition. We observed a main effect of Task Type on connectivity with an ANT seed, with greater connectivity between the ANT and dorsolateral prefrontal cortex (DLPFC) and superior temporal gyrus (STG) when a PM component was included. Post hoc testing based on a significant interaction showed greater ANT-DLPFC connectivity when PM was included with the low and ANT-STG connectivity with the high cognitive load OGT. There was no main effect of N-Back at these locations. Connectivity based on a dorsomedial nucleus of the thalamus seed did not differ according to Task Type at these locations. Conclusions Enhanced connectivity between the ANT and the DLPFC, a brain region with an established role in strategic monitoring for PM cues, arose with a low cognitive load OGT that enabled monitoring. This pattern was absent on directly increasing the cognitive load of the OGT without PM, suggesting specificity for PM. Greater ANT-STG connectivity on PM inclusion in the higher cognitive load OGT condition fits with reports of STG activation on PM through spontaneous retrieval. Differing connectivity based on a dorsomedial nucleus of the thalamus seed suggests ANT specificity. The findings fit with a coordinating role for the ANT in prospective remembering.

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Section: Methodsmentioning

confidence: 99%

Exploring anterior thalamus functional connectivity with cortical regions in prospective memory with ultra-high-field fMRI

Flanagan,

Mansur,

Reichert

et al. 2024

Preprint

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Cognition and Activity of Daily Living Function in people with Parkinson’s disease

Bode,

Kalbe,

Liepelt-Scarfone

2024

J Neural Transm

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The ability to perform activities of daily living (ADL) function is a multifaceted construct that reflects functionality in different daily life situations. The loss of ADL function due to cognitive impairment is the core feature for the diagnosis of Parkinson’s disease dementia (PDD). In contrast to Alzheimer’s disease, ADL impairment in PD can be compromised by various factors, including motor and non-motor aspects. This narrative review summarizes the current state of knowledge on the association of cognition and ADL function in people with PD and introduces the concept of “cognitive ADL” impairment for those problems in everyday life that are associated with cognitive deterioration as their primary cause. Assessment of cognitive ADL impairment is challenging because self-ratings, informant-ratings, and performance-based assessments seldomly differentiate between “cognitive” and “motor” aspects of ADL. ADL function in PD is related to multiple cognitive domains, with attention, executive function, and memory being particularly relevant. Cognitive ADL impairment is characterized by behavioral anomalies such as trial-and-error behavior or task step omissions, and is associated with lower engagement in everyday behaviors, as suggested by physical activity levels and prolonged sedentary behavior. First evidence shows that physical and multi-domain interventions may improve ADL function, in general, but the evidence is confounded by motor aspects. Large multicenter randomized controlled trials with cognitive ADL function as primary outcome are needed to investigate which pharmacological and non-pharmacological interventions can effectively prevent or delay deterioration of cognitive ADL function, and ultimately the progression and conversion to PDD.

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Striato-cortical functional connectivity changes in mild cognitive impairment with Lewy bodies

Novakova,

Gajdos,

Barton

et al. 2024

Parkinsonism & Related Disorders

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Language impairment in Parkinson’s disease: fMRI study of sentence reading comprehension

Cited by 3 publications

References 45 publications

Exploring anterior thalamus functional connectivity with cortical regions in prospective memory with ultra-high-field fMRI

Exploring anterior thalamus functional connectivity with cortical regions in prospective memory with ultra-high-field fMRI

Cognition and Activity of Daily Living Function in people with Parkinson’s disease

Striato-cortical functional connectivity changes in mild cognitive impairment with Lewy bodies

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