Language Dominance in Patients With Malformations of Cortical Development and Epilepsy

Kuchukhidze, Giorgi; Siedentopf, Christian; Unterberger, Iris; Koppelstaetter, Florian; Kronbichler, Martin; Zamarian, Laura; Haberlandt, Edda; Ischebeck, Anja; Delazer, Margarete; Felber, Stephan; Trinka, Eugen

doi:10.3389/fneur.2019.01209

Cited by 5 publications

(3 citation statements)

References 48 publications

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“…Congenital lesions such as malformations of cortical development due to abnormal neuronal proliferation (focal cortical dysplasia type II, tuberous sclerosis, etc.) usually do not bear function as demonstrated by fMRI studies (45,46) and invasive EEG recordings (47). Other possible reasons for amygdala dysfunction might be epilepsy features irrespective of its etiology, e.g., duration of epilepsy, seizure frequency, seizure types etc.…”

Section: Discussionmentioning

confidence: 99%

Emotional Recognition in Patients With Mesial Temporal Epilepsy Associated With Enlarged Amygdala

et al. 2022

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Background:Amygdalae play a central role in emotional processing by interconnecting frontal cortex and other brain structures. Unilateral amygdala enlargement (AE) is associated with mesial temporal lobe epilepsy (mTLE). In a relatively large sample of patients with mTLE and AE, we aimed to evaluate functional integration of AE in emotion processing and to determine possible associations between fMRI activation patterns in amygdala and deficits in emotion recognition as assessed by neuropsychological testing.Methods:Twenty-two patients with drug resistant unilateral mTLE due to ipsilateral AE were prospectively recruited in a large epilepsy unit and compared with 17 healthy control subjects in terms of amygdala volume, fMRI activation patterns and performance in emotion recognition as assessed by comprehensive affect testing system (CATS) and Ekman faces. All patients underwent structural and functional 1.5 Tesla MRI, electro-clinical assessment and neuropsychological testing.Results:We observed BOLD signal ipsilateral to AE (n = 7; group PAT1); contralateral to AE (n = 6; group PAT2) and no activation (n = 9; group PAT3). In the region of interest (ROI) analysis, beta estimates for fearful face > landscape contrast in the left amygdala region did not differ significantly in patients with left TLE vs. patients with right TLE [T(16) = −1.481; p = 0.158]. However, beta estimates for fearful face > landscape contrast in the right amygdala region were significantly reduced in patients with right TLE vs. patients with left TLE [T(16) = −2,922; p = 0.010]. Patients showed significantly lower total scores in CATS and Ekman faces compared to healthy controls.Conclusion:In our cohort, patients with unilateral mesial TLE and ipsilateral AE, an amygdala could display either functional integration in emotion recognition or dysfunction as demonstrated by fMRI. Perception and recognition of emotions were impaired more in right-sided mTLE as compared to left-sided mTLE. Neuropsychological tests showed deficits in emotion recognition in patients as compared to healthy controls.

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Section: Discussionmentioning

confidence: 99%

Emotional Recognition in Patients With Mesial Temporal Epilepsy Associated With Enlarged Amygdala

et al. 2022

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“…19 Several studies have demonstrated malformations to be associated with functional reorganization of the brain. 18,[20][21][22][23] Those studies provide evidence for a developmental or transient reorganization of normal brain networks in response to the wide-range effect of a seemingly focal lesion.…”

Section: Evidence Of Abnormal Functional Connectivity In Fcd-related ...mentioning

confidence: 90%

“…A study of patients with malformations of cortical development (MCD) undergoing task fMRI showed that a subset with FCD had aberrant activation in language regions 19 . Several studies have demonstrated malformations to be associated with functional reorganization of the brain 18,20–23 . Those studies provide evidence for a developmental or transient reorganization of normal brain networks in response to the wide‐range effect of a seemingly focal lesion.…”

Section: Fcd‐related Epilepsy Is a Network Disordermentioning

confidence: 99%

A scoping review of the functional magnetic resonance imaging‐based functional connectivity of focal cortical dysplasia‐related epilepsy

Cohen,

Xie,

Gholipour

et al. 2023

Epilepsia

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Focal cortical dysplasia (FCD) is the most frequent etiology of operable pharmacoresistant epilepsy in children. There is burgeoning evidence that FCD‐related epilepsy is a disorder that involves distributed brain networks. Functional magnetic resonance imaging (fMRI) is a tool that allows one to infer neuronal activity and to non‐invasively map whole‐brain functional networks. Despite its relative widespread availability at most epilepsy centers, the clinical application of fMRI remains mostly task‐based in epilepsy. Another approach is to map and characterize cortical functional networks of individuals using resting state fMRI (rsfMRI).The focus of this scoping review is to summarize the evidence to date of investigations of the network basis of FCD‐related epilepsy, and to highlight numerous potential future applications of rsfMRI in the exploration of diagnostic and therapeutic strategies for FCD‐related epilepsy.There are numerous studies demonstrating a global disruption of cortical functional networks in FCD‐related epilepsy. The underlying pathological subtypes of FCD influence overall functional network patterns. There is evidence that cortical functional network mapping may help to predict postsurgical seizure outcomes, highlighting the translational potential of these findings. Additionally, several studies emphasize the important effect of FCD interaction with cortical networks and the expression of epilepsy and its comorbidities.

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Presurgical brain mapping of language processing with fMRI: state of the art and tendencies

Pechenkova

Panikratova²,

Мершина

et al. 2022

Medicinskaâ vizualizaciâ

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Presurgical brain mapping of language-eloquent cortex aims to minimize its injury during neurosurgery in patients with brain tumors and drug-resistant epilepsy, and thereby, to preserve their quality of life. Two main goals of language mapping are to identify the localization and lateralization of brain regions involved in language. Gold standards for them are the intraoperative mapping and Wada test, respectively; however, due to some limitations of these techniques, non-invasive preliminary language mapping becomes reasonable. During the last years, fMRI has been widely applied for such purposes. Our literature review focuses on innovations and actual tendencies which spread in the field of language mapping via fMRI in the last decade. State-of-the-art knowledge on brain organization of language, which underpins brain mapping of language processing via fMRI, is briefly described in the article. Contemporary studies of fMRI validity in localization and lateralization of language brain regions are considered. Strategies of presurgical language mapping, such as application of tractography in addition to fMRI, combined analysis of fMRI tasks as well as resting-state fMRI are also discussed. Well-established fMRI tasks for brain mapping of language production and comprehension, as well as new experimental developments in this field, are listed and described.

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Language Dominance in Patients With Malformations of Cortical Development and Epilepsy

Cited by 5 publications

References 48 publications

Emotional Recognition in Patients With Mesial Temporal Epilepsy Associated With Enlarged Amygdala

Emotional Recognition in Patients With Mesial Temporal Epilepsy Associated With Enlarged Amygdala

A scoping review of the functional magnetic resonance imaging‐based functional connectivity of focal cortical dysplasia‐related epilepsy

Presurgical brain mapping of language processing with fMRI: state of the art and tendencies

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