Language development of very low birth weight infants and fullterm controls at 12 months of age

Casiro, Oscar G.; Moddemann, Diane; Stanwick, Richard; Panikkar-Thiessen, Vinnie K.; Cowan, Heather; Cheang, Mary

doi:10.1016/0378-3782(90)90007-6

Cited by 52 publications

(30 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…HI is one of the most common causes of neonatal neurological impairment, and a high proportion of those affected go on to experience cognitive and behavioral deficits [[2]; for reviews, see [8], [10]], including difficulty with language acquisition and verbal ability [11,12]. Deficits in RAP have been suggested to be predictive of such language impairments in these and other populations [14,15,16,17,18].…”

Section: Discussionmentioning

confidence: 99%

“…Subsequent impairments include cognitive and behavioral deficits [[2], [9]; for a review, see [10]], and many infants with or at risk for HI demonstrate delayed language acquisition [11] as well as deficits in verbal and language domains [12,13]. Auditory processing deficits have also been reported in infants at risk for HI, and these deficits have been suggested to be both predictive of and possibly causal to later speech and language-related impairments [14,15,16,17,18].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Inhibition of X-Linked Inhibitor of Apoptosis with Embelin Differentially Affects Male versus Female Behavioral Outcome following Neonatal Hypoxia-Ischemia in Rats

et al. 2011

View full text Add to dashboard Cite

Hypoxia-ischemia (HI; concurrent oxygen/blood deficiency) and associated encephalopathy represent a common cause of neurological injury in premature/low-birth-weight infants and term infants with birth complications. Resulting behavioral impairments include cognitive and/or sensory processing deficits, as well as language disabilities, and clinical evidence shows that male infants with HI exhibit more severe cognitive deficits compared to females with equivalent injury. Evidence also demonstrates activation of sex-dependent apoptotic pathways following HI events, with males preferentially activating a caspase-independent cascade of cell death and females preferentially activating a caspase-dependent cascade following neonatal hypoxic and/or ischemic insults. Based on these combined data, the ‘female protection’ following HI injury may reflect the endogenous X-linked inhibitor of apoptosis (XIAP), which effectively binds effector caspases and halts downstream cleavage of effector caspases (thus reducing cell death). To test this theory, the current study utilized neonatal injections of vehicle or embelin (a small molecule inhibitor of XIAP) in male and female rats with or without induced HI injury on postnatal day 7 (P7). Subsequent behavioral testing using a clinically relevant task revealed that the inhibition of XIAP exacerbated HI-induced persistent behavioral deficits in females, with no effect on HI males. These results support sex differences in mechanisms of cell death following early HI injuries, and suggest a potential clinical benefit from the development of sex-specific neuroprotectants for the treatment of HI.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Inhibition of X-Linked Inhibitor of Apoptosis with Embelin Differentially Affects Male versus Female Behavioral Outcome following Neonatal Hypoxia-Ischemia in Rats

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Nevertheless, developmental delays in many aspects of speech and language have been reported in preterm populations, particularly those born VLBW (Casiro et al, 1990;Saavalainen et al, 2006;Vohr, Garcia Coll, & Oh, 1988). Whereas about 5-10% of all full-term children beginning school can be classified as having developmentally based language impairments (Tomblin, 1996), estimates of language delay and language impairment in LBW and VLBW populations range from 25-78% (Casiro et al, 1990;Vohr et al, 1988). For example, 40% of VLBW children born in the Netherlands in 1983 were found to have abnormal language abilities at 5 years of age (Veen et al, 1991).…”

Section: Introductionmentioning

confidence: 99%

Understanding language and cognitive deficits in very low birth weight children

Ortiz-Mantilla

Choudhury

Leevers

et al. 2008

Developmental Psychobiology

113

View full text Add to dashboard Cite

Very-low-birth-weight infants are at much higher risk for cognitive and language delays but the nature of such deficits is not clearly understood. Given increasing rates of prematurity and infants born very-low-birth-weight, examination of mechanisms that underlie poorer developmental outcome is essential. We investigated language and cognitive abilities in very-low and normal birth-weight infants to determine whether performance differences were due to poorer global cognitive performance or to deficits in specific processing abilities. Thirty-two very-low and 32 normal birth-weight infants received visual and auditory-visual habituation recognition-memory tasks, and standardized language and cognitive assessments. Very-low-birth-weight infants performed more poorly on visual and auditory-visual habituation tasks and scored lower than controls on cognitive and language measures. These findings suggest that differences in language abilities in very-low-birth-weight children may be part of a global deficit that impacts many areas of cognitive functioning rather than a specific impairment in rapid auditory processing.

show abstract

“…Indeed, despite the varying etiologies noted above, both term and preterm HI populations show increased frequencies of language deficits [32,33,34,35,36,37], memory impairments [38,39,40,41] and developmental disorders such as ADHD [31,42,43,44,45,46,47]. …”

Section: Introductionmentioning

confidence: 99%

Spatial Working Memory Deficits in Male Rats Following Neonatal Hypoxic Ischemic Brain Injury Can Be Attenuated by Task Modifications

et al. 2014

View full text Add to dashboard Cite

Hypoxia-ischemia (HI; reduction in blood/oxygen supply) is common in infants with serious birth complications, such as prolonged labor and cord prolapse, as well as in infants born prematurely (<37 weeks gestational age; GA). Most often, HI can lead to brain injury in the form of cortical and subcortical damage, as well as later cognitive/behavioral deficits. A common domain of impairment is working memory, which can be associated with heightened incidence of developmental disorders. To further characterize these clinical issues, the current investigation describes data from a rodent model of HI induced on postnatal (P)7, an age comparable to a term (GA 36–38) human. Specifically, we sought to assess working memory using an eight-arm radial water maze paradigm. Study 1 used a modified version of the paradigm, which requires a step-wise change in spatial memory via progressively more difficult tasks, as well as multiple daily trials for extra learning opportunity. Results were surprising and revealed a small HI deficit only for the final and most difficult condition, when a delay before test trial was introduced. Study 2 again used the modified radial arm maze, but presented the most difficult condition from the start, and only one daily test trial. Here, results were expected and revealed a robust and consistent HI deficit across all weeks. Combined results indicate that male HI rats can learn a difficult spatial working memory task if it is presented in a graded multi-trial format, but performance is poor and does not appear to remediate if the task is presented with high initial memory demand. Male HI rats in both studies displayed impulsive characteristics throughout testing evidenced as reduced choice latencies despite more errors. This aspect of behavioral results is consistent with impulsiveness as a core symptom of ADHD—a diagnosis common in children with HI insult. Overall findings suggest that task specific behavioral modifications are crucial to accommodating memory deficits in children suffering from cognitive impairments following neonatal HI.

show abstract

Language development of very low birth weight infants and fullterm controls at 12 months of age

Cited by 52 publications

References 20 publications

Inhibition of X-Linked Inhibitor of Apoptosis with Embelin Differentially Affects Male versus Female Behavioral Outcome following Neonatal Hypoxia-Ischemia in Rats

Inhibition of X-Linked Inhibitor of Apoptosis with Embelin Differentially Affects Male versus Female Behavioral Outcome following Neonatal Hypoxia-Ischemia in Rats

Understanding language and cognitive deficits in very low birth weight children

Spatial Working Memory Deficits in Male Rats Following Neonatal Hypoxic Ischemic Brain Injury Can Be Attenuated by Task Modifications

Contact Info

Product

Resources

About