Language and Focal Brain Lesion in Childhood

Avila, Lia Nunes de; Riesgo, Rudimar dos Santos; Pedroso, Fleming Salvador; Goldani, Marcelo Zubarán; Danesi, Marlene Canarim; Ranzan, Josiane; Sleifer, Pricila

doi:10.1177/0883073809350724

Cited by 23 publications

(20 citation statements)

References 32 publications

(38 reference statements)

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“…Besides, aphasia secondary to thalamic injury has rarely been described. 1 It was initially reported in a child with a left-sided thalamic tumor. 2 By contrast, thalamic aphasia following ischemic thalamic infarcts are uncommon.…”

Section: Introductionmentioning

confidence: 99%

Unusual Presentation of Childhood Reversible Angiopathy: Aphasia due to Acute Bilateral Paramedian Thalamic Infarct

et al. 2018

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An 8-year-old right-handed girl manifested aphasia after bilateral thalamic infarcts. The features of thalamic aphasia are similar to that of previously reported patients with thalamic lesions. Paucity of speech, reduced voice volume, some paraphasia, and severe dysgraphia were present, but comprehension and repetition were preserved. Thalamic aphasia is usually associated with left thalamic lesions. Our patient also had spatial neglect and anosognosia probably due to right thalamic infarction. She had recovered near-normal speech after rehabilitation.

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Section: Introductionmentioning

confidence: 99%

Unusual Presentation of Childhood Reversible Angiopathy: Aphasia due to Acute Bilateral Paramedian Thalamic Infarct

et al. 2018

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“…Another study found very few difficulties with pragmatics or conversational language [25]. Phonological (speech sounds) and syntactic (grammatical) impairments were found in 40.6% of their group and semantic difficulties were found in 34.4% children.…”

Section: Language the Clinical Evaluation Of Language Fundamentals (mentioning

confidence: 94%

“…In many studies, early age at stroke onset was associated with poorer outcomes, including lower FSIQ [27], orienting attention [45], expressive and receptive language skills [25,24,29,32], verbal memory [46,24], perceptual reasoning [24] and working memory [31].…”

Section: Factors Associated With Neuropsychological and Behavioural Omentioning

confidence: 99%

Neuropsychological outcome following childhood stroke – a review

et al. 2017

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Objectives. Childhood stroke is a rare but devastating occurrence. Its infrequency has meant that a clear body of knowledge has not been fully established regarding its impact on neuropsychological outcome. Our aims were i) to critically review the recent literature on neuropsychological outcome following childhood stroke; ii) to investigate the factors related to neuropsychological outcome following childhood stroke.Methods. Literature searches were conducted and revealed 39 relevant papers from the period 1999-2015.Results. The review found that a significant number of children experience difficulties in a wide range of neuropsychological domains, with particular vulnerabilities noted in attention, speed of information processing and executive functioning. There were inconsistent findings regarding the correlates of neuropsychological outcome, which is likely due to methodological limitations of the studies.Conclusions. This review strongly indicates that childhood stroke can affect a myriad of neuropsychological domains, with attention, speed of processing and executive function particularly vulnerable. Methodological issues, particularly around heterogeneous samples and measurement difficulties, limit the conclusions that can be drawn regarding the predictors of outcome.

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“…Childhood aphasia (CA) is defined as a language impairment that affects previously acquired linguistic abilities, which cannot be explained by other cognitive or physical disorders (Aram, 1998). Since the diagnosis of CA requires a minimum development of linguistic skills prior to the brain injury, the age of 2 years is the established cut-off to differentiate CA from language developmental disorders (Woods and Teuber, 1978;Aram et al, 1985;Van Hout, 1997;Van Hout, 2003;Avila et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Pharmacotherapy of Traumatic Childhood Aphasia: Beneficial Effects of Donepezil Alone and Combined With Intensive Naming Therapy

et al. 2020

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At present, language therapy is the only available treatment for childhood aphasia (CA). Studying new interventions to augment and hasten the benefits provided by language therapy in children is strongly needed. CA frequently emerges as a consequence of traumatic brain injury and, as in the case of adults, it may be associated with dysfunctional activity of neurotransmitter systems. The use of cognitive-enhancing drugs, alone or combined with aphasia therapy, promotes improvement of language deficits in aphasic adults. In this study we report the case of a 9-year-old right-handed girl, subject P, who had chronic anomic aphasia associated with traumatic lesions in the left temporal-parietal cortex. We performed a single-subject, open-label study encompassing administration of the cholinergic agent donepezil (DP) alone during 12 weeks, followed by a combination of DP and intensive naming therapy (INT) for 2 weeks and thereafter by a continued treatment of DP alone during 12 weeks, a 4-week washout period, and another 2 weeks of INT. Four comprehensive language and neuropsychological evaluations were performed at different timepoints along the study, and multiple naming evaluations were performed after each INT in order to assess performance in treated and untreated words. Structural magnetic resonance imaging (MRI) was performed at baseline. MRI revealed two focal lesions in the left hemisphere, one large involving the posterior inferior and middle temporal gyri and another comprising the angular gyrus. Overall, baseline evaluation disclosed marked impairment in naming with mild-to-moderate compromise of spontaneous speech, repetition, and auditory comprehension. Executive and attention functions were also affected, but memory, visuoconstructive, and visuoperceptive functions were preserved. Treatment with DP alone significantly improved spontaneous speech, auditory comprehension, repetition, and picture naming, in addition to processing speed, selective, and sustained attention. Combined DP-INT further improved naming. After washout of both interventions, most of these beneficial changes remained. Importantly, DP produced no side effects and subject P attained the necessary level of language competence

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Language and Focal Brain Lesion in Childhood

Cited by 23 publications

References 32 publications

Unusual Presentation of Childhood Reversible Angiopathy: Aphasia due to Acute Bilateral Paramedian Thalamic Infarct

Unusual Presentation of Childhood Reversible Angiopathy: Aphasia due to Acute Bilateral Paramedian Thalamic Infarct

Neuropsychological outcome following childhood stroke – a review

Pharmacotherapy of Traumatic Childhood Aphasia: Beneficial Effects of Donepezil Alone and Combined With Intensive Naming Therapy

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