Langlois Reagent Mediated Tandem Cyclization of o-Hydroxyaryl Enaminones for the Synthesis of 3-(Trifluoromethyl)chromones

Abstract

An efficient and facile synthesis of various 3-trifluoromethyl-chromones via enamino ketone is de-scribed. The key step in the synthesis involves introduction of trifluoromethyl (CF3) moiety on chromone structure. The significant features of this method include simple opera-tional procedure, high purity and yield of the product and excellent regio-selectivity.

Recent advances in TBHP‐promoted heterocyclic ring construction via annulation/cyclization

“…Plausible reaction mechanism [45]. molecule to a chromone structure was a crucial step in the synthesis [46]. This method's noteworthy attributes included its easy-to-use operating procedures, outstanding regioselectivity, and high product purity and yield.…”

“…Pyrroles are widely used in chemistry as synthetic building blocks because of their many uses in the production S C H E M E 2 5 Synthesis of 3-(trifluoromethyl)chromones [46].…”

“…Behera and colleagues developed an effective and straightforward synthesis of several 3‐(trifluoromethyl)chromones ( 41 ) in good yields from enamino ketones ( 34 ) (Scheme 25). The addition of a trifluoromethyl (CF 3 ) molecule to a chromone structure was a crucial step in the synthesis [46]. This method's noteworthy attributes included its easy‐to‐use operating procedures, outstanding regioselectivity, and high product purity and yield.…”