Abstract:Background
Epicutaneous sensitization is an important route of immunization for allergens in atopic diseases; however, studies have also shown that application with protein on the intact skin induces antigen‐specific tolerance. Langerhans cells (LCs) play an immunosuppressive role in several inflammatory skin diseases and mouse models, and the role of LCs in the skin‐induced tolerance is not fully understood.
Methods
Langerin‐DTA mice that were deficient in LCs were utilized to produce the model of skin‐induce… Show more
“…A recent study showed that LCs played an immunosuppressive role when OVA was applied on the intact skin, in company with the induction of IL-10 in LCs in skin-draining LNs. 72 However, this does not seem to be our case, because Langerin 1 migDCs in EDLN did not exhibit any transcriptional change of regulatory T cell-inducing signals including IL-10 and TGF-b, or ALDH1A2. More likely, the anti-T FH /T H 2 effect of LCs is related to their immune suppression function in situ in the skin, in keeping with LC ontogeny not only as DCs but also as nonmigratory macrophages.…”
Section: Do Lcs Function As Nonmigratory Cells In the Skin To Suppress T Fh /T H 2 Response?mentioning
“…A recent study showed that LCs played an immunosuppressive role when OVA was applied on the intact skin, in company with the induction of IL-10 in LCs in skin-draining LNs. 72 However, this does not seem to be our case, because Langerin 1 migDCs in EDLN did not exhibit any transcriptional change of regulatory T cell-inducing signals including IL-10 and TGF-b, or ALDH1A2. More likely, the anti-T FH /T H 2 effect of LCs is related to their immune suppression function in situ in the skin, in keeping with LC ontogeny not only as DCs but also as nonmigratory macrophages.…”
Section: Do Lcs Function As Nonmigratory Cells In the Skin To Suppress T Fh /T H 2 Response?mentioning
“…Upon antigen uptake, these DCs can migrate to local lymph nodes where they exert classical DC functions and drive adaptive responses to food antigens (18). Dermal CD11b+ DCs as well as Langerhans cells play a central role in the induction of tolerance to allergens in the skin (19)(20)(21).…”
Section: Immunological Mechanisms Of Ige-mediated Food Allergymentioning
“…Recent studies suggested involvement of Langerhans cells and regulatory T cells in prophylactic and therapeutic models with e.c. OVA administration [29,30]. Interestingly, e.c.…”
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