Langerhans Cells in Mouse Skin Experimentally Deprived of its Neural Crest Component*

Breathnach, A. S.; Silvers, Willys K.; Smith, J.; Heyner, Susan

doi:10.1038/jid.1968.18

Cited by 97 publications

(21 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a landmark experiment, it was shown that when a skin graft from the developing limb-buds from embryonic day (E) 10.5 mouse embryos was transplanted into the spleen of histocompatible recipients, Birbeck granule-positive LCs developed. Limb skin, however, is not colonized by neural crest-derived melanocyte precursors until E11.5, thus suggesting that LCs are not neural-crest derived [15].…”

Section: Lc Origin: In Ovo Veritas?mentioning

confidence: 91%

“…Birbeck granules have also been described in the mouse spleen [15], and thus the LCs observed in these experiments might have originated from donor-derived precursors. In contrast, chickens were thought to lack LCs, and therefore, Reams and Tompkins grafted neural crest-free limb buds of E10.5 mouse embryos into chick embryos [16].…”

Section: Lc Origin: In Ovo Veritas?mentioning

confidence: 93%

See 1 more Smart Citation

Development and homeostasis of ‘resident’ myeloid cells: the case of the Langerhans cell

Chorro

Geissmann

2010

Trends in Immunology

View full text Add to dashboard Cite

Section: Lc Origin: In Ovo Veritas?mentioning

confidence: 91%

Section: Lc Origin: In Ovo Veritas?mentioning

confidence: 93%

Development and homeostasis of ‘resident’ myeloid cells: the case of the Langerhans cell

Chorro

Geissmann

2010

Trends in Immunology

View full text Add to dashboard Cite

“…However, several subsequent studies refuted the hypothesis that LCs were related to melanocytes. Ultrastructural studies using electron microscopy identified important differences between LCs and melanocytes, showing that LCs lacked melanin granules but possessed specific cytoplasmic granules that were later defined as Birbeck granules 8 , 9 , 10 . Adoptive transfer studies were also against the melanocyte hypothesis 10 , 11 .…”

Section: Historical Perspectivementioning

confidence: 99%

“…Ultrastructural studies using electron microscopy identified important differences between LCs and melanocytes, showing that LCs lacked melanin granules but possessed specific cytoplasmic granules that were later defined as Birbeck granules 8 , 9 , 10 . Adoptive transfer studies were also against the melanocyte hypothesis 10 , 11 . In these studies, mouse embryonic limb buds collected either before (E10.5) or after (E11.5) neural crest invasion were grafted into the spleen of adult mice.…”

Section: Historical Perspectivementioning

confidence: 99%

Ontogeny and homeostasis of Langerhans cells

2010

View full text Add to dashboard Cite

Langerhans cells (LCs) refer to the dendritic cells (DCs) that populate the epidermis. Strategically located at one of the body's largest interfaces with the external environment, they form the first line of defense against pathogens that breach the skin. Although LCs share several phenotypical and functional features with lymphoid and non-lymphoid organ DCs, they also have unique properties that distinguish them from most DC populations. In this review, we will discuss the key mechanisms that regulate LC homeostasis in quiescent and inflamed skin. We will also discuss recent evidence that suggests that LCs arise from dedicated precursors during early embryonic development.

show abstract

“…Langerhans cells are macrophage-equivalent cells found in the skin and oral mucosa (Breathnach et al, 1967). They have been associated with antigen processing (SilberbergSinakin et al, 1976) and delayed hypersensitivity (Toews et al, 1980).…”

mentioning

confidence: 98%

Alpha Tocopherol Alters the Distribution of Langerhans Cells in DMBA-treated Hamster Cheek Pouch Epithelium

et al. 1985

View full text Add to dashboard Cite

Thirty-seven adult male and female golden hamsters (Mesocricetus auratus) were divided into four experimental groups. In Group A, the animals served as untreated controls, having the left buccal pouches painted with mineral oil. In Group B, the animals received 10 mg vitamin E (alpha tocopherol) in peanut oil by the oral route, with a fine pipette, twice weekly. In Group C animals, the left buccal pouch was painted three times weekly with DMBA (0.5% solution of 7,12 dimethylbenz(a)anthracene in heavy mineral oil). Group D animals received both vitamin E and DMBA in the amounts indicated for Groups B and C, with the vitamin E being administered on days alternate to the DMBA painting, also in the manner described for the above groups. All animals were killed after eight weeks of treatment. Epithelial whole mounts were prepared from the left buccal pouches. These specimens were then stained for ATPase to demonstrate the presence of Langerhans cells (LCs). A notably decreased density of LCs was observed after treatment with DMBA. Vitamin E administration in addition to DMBA treatment resulted in a less dramatic decrease in LC density. Since vitamin E has been shown to retard experimental oral carcinogenesis, vitamin E may retard carcinogenesis by maintaining the number of Langerhans cells.

show abstract

Langerhans Cells in Mouse Skin Experimentally Deprived of its Neural Crest Component*

Cited by 97 publications

References 22 publications

Development and homeostasis of ‘resident’ myeloid cells: the case of the Langerhans cell

Development and homeostasis of ‘resident’ myeloid cells: the case of the Langerhans cell

Ontogeny and homeostasis of Langerhans cells

Alpha Tocopherol Alters the Distribution of Langerhans Cells in DMBA-treated Hamster Cheek Pouch Epithelium

Contact Info

Product

Resources

About