Langerhans cell histiocytosis or tuberculosis on a medieval child (Oppidum de la Granède, Millau, France – 10th–11th centuries AD)

Colombo, Antony; Saint-Pierre, Christophe; Naji, Stephan; Panuel, M.; Coqueugniot, Hélène; Dutour, Olivier

doi:10.1016/j.tube.2015.02.003

Cited by 8 publications

(4 citation statements)

References 38 publications

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“…Additionally, tuberculosis has also been associated with porous cranial lesions (Colombo et al, 2015; Masson et al, 2013; Pósa et al, 2015). During skeletal growth, hypervascularized hematopoietic bone marrow would be a perfect niche for the mycobacterium, affecting proximal areas of cortical and trabecular resorption (Blondiaux et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Frequency and co‐occurrence of porous skeletal lesions in identified non‐adults from Portugal (19th to 20th centuries) and its association with respiratory infections as cause of death

Gomes

Petit

Dutour

et al. 2022

Intl J of Osteoarchaeology

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Porous skeletal lesions (PSL) have been reported in scientific literature since the 19th century, yet their etiology(ies) remains a complex issue under debate. The aim of this study is twofold: evaluate the frequency, co-occurrence, and association of PSL with biological sex and age at death and examine possible relationships between the presence/absence of PSL with the known cause of death (COD). Fifty-six non-adult skeletons from the Coimbra Identified Skeletal Collection (19th to 20th centuries) were evaluated. Lesion presence/absence was recorded macroscopically without previous knowledge of the biographic data. Forty-nine individuals (87.5%) presented at least one type of PSL, and cribra femoralis was the most frequent (n = 39), followed by orbitalia (n = 26), humeralis (n = 15), and cranii (n = 6). Porous skeletal lesions affected males and females equally, and younger individuals presented a significantly higher frequency of cribra femoralis. Even without statistical significance, the cooccurrence of cribra orbitalia, humeralis, and femoralis was common, as described in the "cribrous syndrome" where it is advocated a shared etiology for these lesions, based on macroscopic, microscopic, and radiological features. Individuals with a COD as respiratory infection, particularly pulmonary tuberculosis, exhibited a higher risk of expressing cribra orbitalia. The results of this investigation suggest an influence of age and infectious diseases in the expression of PSL, impacting the bioarchaeological interpretations. There is a need for further research in clinical, autopsy, and identified skeletal collection samples to further understand co-occurrence, comorbidity, and possible frailty related to PSL.

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Section: Introductionmentioning

confidence: 99%

Frequency and co‐occurrence of porous skeletal lesions in identified non‐adults from Portugal (19th to 20th centuries) and its association with respiratory infections as cause of death

Gomes

Petit

Dutour

et al. 2022

Intl J of Osteoarchaeology

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“…Lytic cranial lesions have been reported by Columbo et al (2015) [35] on a mediaeval child (1-2.5 years) from France, and they also suggested a diagnosis of either Langerhans cell histiocytosis or TB, or in fact perhaps both conditions, as well as by Abegg et al (2020) [36] on a Neolithic child (2-6 years) from Switzerland, and Geber (2015) [37] on a post medieval child (9 years) from Ireland.…”

Section: Discussionmentioning

confidence: 99%

A case of childhood tuberculosis from late mediaeval Somerset, England

2021

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“…The evidences would be punched‐out osteolytic lesions and a variable regional vertebral involvement that could have led to the collapse of both anterior and posterior vertebral elements. However, this pathology is quite rare and it is worth noting that this is usually related to childhood; therefore, it is possible to exclude this aetiology as well (Bauduer, Bessou, Guyomarc'h, Mercier, & Castex, ; Colombo et al, ; Spigelman, Pap, & Donoghue, ; see also clinical data: Khung et al, ; Lam, Reddy, Mayer, Lin, & Jea, ).…”

Section: Discussionmentioning

confidence: 99%

A probable case of subligamentous tuberculous spondylitis: The concealed body of theLate Modern Period(early 16th century to early 20th century),Franciscancrypt ofSt. AnthonyandSt. Eusebiuschurch,Lombardy,Italy

Larentis

Tonina

Tesi

et al. 2019

Intl J of Osteoarchaeology

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This paper presents a probable case of subligamentous tuberculous spondylitis (STBS), a rare form of extrapulmonary tuberculosis, diagnosed in the skeleton of a middle‐aged male discovered in the ossuary of the Franciscan crypt of the St. Anthony and St. Eusebius church, which lies in north‐western Italy. The skeleton can be dated back between the 17th and 19th centuries. This rare type of tuberculosis was identified in the thoracic and lumbar spine, with no further evidences at the level of the cranial and other postcranial bones. The concomitance of osteoclastic and osteoblastic activities, scalloping, reactive bone formation area, anterior, and lateral ligaments ossification was observed and allowed us to perform a morphological STBS diagnosis. The subject presented here contributes to the literature related to the prevalence of tuberculosis in Italy during the last centuries. Moreover, we also focus our attention on some osteopathological criteria that can prove useful for the diagnosis of extrapulmonary tuberculosis.

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Langerhans cell histiocytosis or tuberculosis on a medieval child (Oppidum de la Granède, Millau, France – 10th–11th centuries AD)

Cited by 8 publications

References 38 publications

Frequency and co‐occurrence of porous skeletal lesions in identified non‐adults from Portugal (19th to 20th centuries) and its association with respiratory infections as cause of death

Frequency and co‐occurrence of porous skeletal lesions in identified non‐adults from Portugal (19th to 20th centuries) and its association with respiratory infections as cause of death

A case of childhood tuberculosis from late mediaeval Somerset, England

A probable case of subligamentous tuberculous spondylitis: The concealed body of theLate Modern Period(early 16th century to early 20th century),Franciscancrypt ofSt. AnthonyandSt. Eusebiuschurch,Lombardy,Italy

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