Langerhans Cell Histiocytosis of Bilateral Parotid and Submandibular Glands

Abstract

Langerhans cell histiocytosis is a disorder of the mononuclear phagocytic system. Virtually any organ can be involved, the bone, skin, lungs, and pituitary gland being the most common. We describe the case of a 30-year-old man who presented with painless neck swelling. 18 F-FDG PET/ CT showed bilateral bulky parotid and submandibular glands with increased metabolic activity. Histopathology confirmed the diagnosis of Langerhans cell histiocytosis. To our knowledge, there has been no description of 18 F-FDG PET/CT findings in Langerhans cell histiocytosis of salivary glands in literature. We aim to aid in the diagnosis and management of this rare presentation.

Multisystemic recurrent Langerhans cell histiocytosis misdiagnosed with chronic inflammation at the first diagnosis: A case report

“…In the diagnosis of LCH, tissue biopsy, immunohistochemical staining[ 3 ], and 18 F fluorodeoxyglucose PET/CT[ 10 ] can aid in the clinical treatment of LCH patients. In this particular case, the imaging findings and initial clinical manifestation of central diabetes insipidus strongly indicated the possibility of HPR-LCH.…”

Coexistence of Langerhans Cell Histiocytosis and Ganglioneuroblastoma Revealed by 18F-FDG PET/CT in a Pediatric Patient

“…The results from the specimen of an excisional biopsy led to a diagnosis of Langerhans cell histiocytosis (LCH). 18 F-FDG PET/CT was implemented for staging 1,2 . The MIP image ( A ) showed intense abnormal activity (arrow) in the left mandible with SUV max of 8.1.…”