Langerhans Cell Histiocytosis Associated with Partial DiGeorge Syndrome in a Newborn

Abstract

This case supports the role of the thymus n the pathogenesis of LCH.

New Insights into the Diagnosis and Management of Pregnancy-Related Diabetes Insipidus

“…In Langerhans cell histiocytosis early infiltration of the hypothalamus and pituitary stalk causes central diabetes insipidus. Combined Langerhans cell histiocytosis and DiGeorge Syndrome displaying multisystemic involvement of Letterer-Siewe disease at birth has been reported (Levendoglu et al, 1996). Transiently, central diabetes insipidus in the neonate is described in association with hypotonia, dysmorphism and marked speech delay due to 22q13 deletion syndrome (Barakat et al, 2004).…”