Langerhans cell histiocytosis and associated malignancies: A retrospective analysis of 270 patients

Incidental Langerhans cell histiocytosis associated with metastatic neuroendocrine tumor in the adult liver

“…BRAF V600E immunohistochemistry was positive only in the LCH (Figure 1I), consistent with the subclonal allele frequency. Furthermore, LCH are known to harbor frequent mutations in BRAF p.V600E or MAP2K1 , but not in TSC2 1–3 . Pancreatic WD‐NET, on the contrary, demonstrate frequent mutations in MEN1 , DAXX , ATRX , and TSC2 , but not in BRAF 4–6 …”

“…Furthermore, LCH are known to harbor frequent mutations in BRAF p.V600E or MAP2K1 , but not in TSC2 . 1 , 2 , 3 Pancreatic WD‐NET, on the contrary, demonstrate frequent mutations in MEN1 , DAXX , ATRX , and TSC2 , but not in BRAF . 4 , 5 , 6 …”

“…Furthermore, LCH are known to harbor frequent mutations in BRAF p.V600E or MAP2K1, but not in TSC2. [1][2][3] Pancreatic WD-NET, on the contrary, demonstrate frequent mutations in MEN1, DAXX, ATRX, and TSC2, but not in BRAF. [4][5][6] This is an unusual case of metastatic WD-NET with coexisting LCH, highlighting that adult LCH often co-occurs with other malignancies.…”

“…[4][5][6] This is an unusual case of metastatic WD-NET with coexisting LCH, highlighting that adult LCH often co-occurs with other malignancies. [1][2][3] The patient received peptide receptor radionuclide therapy for WD-NET (LCH not treated) and has been alive >1 year post-biopsy.…”

Langerhans Cell Histiocytosis in Children: Literature Review

“…У больных, перенесших ГКЛ, в дальнейшем отмечается более высокая, чем в среднем по популяции, частота Обзор литературы Review развития злокачественных заболеваний, которая достигает среди взрослых уровня 32% [10]. При этом наиболее часто диагностируются различные формы лейкозов [11].…”