Langerhans cell histiocytosis: a 16-year experience

Campos, Márcia Kanadani; Viana, Marcos Borato; Oliveira, Benigna Maria de; Ribeiro, Daniel Dias; Silva, Cláudia Márcia de Resende

doi:10.2223/jped.1581

Cited by 20 publications

(31 citation statements)

References 27 publications

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“…[10][11][12] Previous epidemiologic studies have reported 17 cases of oral LCH during a period of 40 years, 4 cases in a period of 16 years and 3 cases in a 30-year period, [10][11][12] indicating the low prevalence of the disease.…”

Section: Discussionmentioning

confidence: 99%

A Retrospective Analysis of Oral Langerhans Cell Histiocytosis in Iranian Population: A 20-Year Evaluation

Atarbashi-Moghadam

Hashemi

Lotfi

et al. 2015

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Section: Discussionmentioning

confidence: 99%

A Retrospective Analysis of Oral Langerhans Cell Histiocytosis in Iranian Population: A 20-Year Evaluation

Atarbashi-Moghadam

Hashemi

Lotfi

et al. 2015

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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“…Classification of the writing group of the Histiocytes Society defines three stages of LCH: (stage 1) single system disease; (stage 2) multisystem disease; (stage 3) multisystem disease with evidence of organ dysfunction. [10] According to this staging present case patient was categorized in stage 2 after ruling out multi organ dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Langerhans cell histiocytosis of the temporal bone in a child

Chakravarti¹,

Gupta²,

Jk³

2011

JCR

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Abstract:Langerhans cell histiocytosis of temporal bone is a benign tumor like condition with variable clinical course. This rare clinical entity may mimic common ENT clinical condition like otitis media , mastoiditis and otitis externa . A high index of suspicion is required to reach to a diagnosis of langerhans cell histiocytosis to prevent delay in proper management of this disease. langerhans cell histiocytosis, temporal bone.

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“…Diabetes insipidus occurs in about 11% to 40% of patients. [8,9] This patient also had diabetes insipidus which was treated with vasopressin. Regression of pulmonary symptoms and chest radiographic infiltrates may occur in 10% to 25% of patients within several months of diagnosis, although the disease does not disappear entirely without some residual symptoms.…”

Section: Histiocytes Are Showing Strong Diffuse Membranous Staining Wmentioning

confidence: 97%

Dispnea After Appendectomy Operation: Case Report

Arslan¹,

Biyikli²,

Yıldız³

et al. 2008

TUTFD

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Pulmonary Langerhans cell histiocytosis (PLCH) is a rare interstitial lung disease. Young male adults develop the disease most frequently. Greater than 90% of cases of PLCH occur in smokers. Diabetes insipidus (DI) occurs in about 11% to 40% of patients and pneumothoraces occur in 10% to 30% of patients. The diagnosis of PLCH can be confirmed by BAL, transbronchial biopsy, or surgical lung biopsy. CASE REPORTA 19-year-old male presented with a four-week history of dyspnea and hemoptysis which had begun after the appendectomy operation, which was performed in emergency conditions, and worsened with time. Previous medical details were not remarkable except for a history of frequent thirst and excessive urine volume. He had also a smoking history of 1 pack/ year. Physical examination revealed that the patient was tachypneic, but not in respiratory distress, with a respiratory rate of 32 breaths per min. He had no cyanosis and edema. There were erythematous papular skin lesions at axilla, postauricula and scalp. On auscultation rales were present bilaterally at the mid and lower zones of the lungs. Chest radiography revealed diffuse micronodular and interstitial-appearing infiltrates and small cystic air spaces (Fig. 1). High resolution computed tomography (HRCT) scan showed bilaterally uniform thin-walled cysts of 1-1.5 cm in diameter suggesting PLCH and Lymphangiomyomatosis (Fig. 2).Pulmoner Langerhans hücreli histiyositoz (PLCH) nadir görülen bir interstisyel akciğer hastalığıdır. Tahmini prevalansı milyonda iki ila beş arasında olup özellikle genç erkeklerde görülür. Olguların %90'ından fazlası sigara içen-lerde görülür. %10-%40'ında diabetes insipidus eşlik eder ve %10-%30'unda pnömotoraks görü-lebilir. Tanı BAL, transbronşiyal biyopsi veya açık akciğer biyopsisi ile konur. Apandektomi operasyonu sonrası gelişen dispne şikayeti ile başvuran, diabetes insipidusun eşlik ettiği ve transbronşiyal akciğer biyopsisi ile PLCH tanısı alan olguyu sunuyoruz.Anahtar sözcükler: Pulmoner Langerhans hücreli histiyositoz; intertisyel akciğer hastalığı; diabetes insipidus; transbronşiyal akciğer biyopisi; dispne.Pulmonary Langerhans cell histiocytosis (PLCH) is a rare interstitial lung disease. Its estimated prevalence is two to five cases per million. Young male adults develop the disease most frequently. Greater than 90% of cases of PLCH occur in smokers. Diabetes insipidus (DI) occurs in about 11% to 40% of patients and pneumothoraces occur in 10% to 30% of patients. The diagnosis of PLCH can be confirmed by BAL, transbronchial biopsy, or surgical lung biopsy. We present a case referred to us with dispnea developed after appendectomy operation, coexisting with DI, and diagnosed to have PLCH using transbronchial lung biopsy.

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Langerhans cell histiocytosis: a 16-year experience

Abstract: The clinical manifestations of Langerhans cell histiocytosis vary widely, with a high relapse rate and low mortality rate.

Cited by 20 publications

References 27 publications

A Retrospective Analysis of Oral Langerhans Cell Histiocytosis in Iranian Population: A 20-Year Evaluation

A Retrospective Analysis of Oral Langerhans Cell Histiocytosis in Iranian Population: A 20-Year Evaluation

Langerhans cell histiocytosis of the temporal bone in a child

Dispnea After Appendectomy Operation: Case Report

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