Langerhans Cell Histiocytosis

Fraïtag, Sylvie; Donadieu, Jean

doi:10.1002/9781119142812.ch90

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2021

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“…LCH is a rare disease characterized by the aberrant clonal proliferation of Langerhans cells. Blistering presentation in cutaneous Langerhans cell histiocytosis, even if infrequent, may happen in the self-healing form ( Figure 10 a) [ 21 , 22 , 23 , 24 ].…”

Section: Etiologiesmentioning

confidence: 99%

How to Deal with Skin Biopsy in an Infant with Blisters?

Leclerc‐Mercier

2021

Dermatopathology

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The onset of blisters in a neonate or an infant is often a source of great concern for both parents and physicians. A blistering rash can reveal a wide range of diseases with various backgrounds (infectious, genetic, autoimmune, drug-related, traumatic, etc.), so the challenge for the dermatologist and the pediatrician is to quickly determine the etiology, between benign causes and life-threatening disorders, for a better management of the patient. Clinical presentation can provide orientation for the diagnosis, but skin biopsy is often necessary in determining the cause of blister formations. In this article, we will provide information on the skin biopsy technique and discuss the clinical orientation in the case of a neonate or infant with a blistering eruption, with a focus on the histology for each etiology.

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Section: Etiologiesmentioning

confidence: 99%

How to Deal with Skin Biopsy in an Infant with Blisters?

Leclerc‐Mercier

2021

Dermatopathology

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Langerhans Cell Histiocytosis

Cited by 1 publication

References 38 publications

How to Deal with Skin Biopsy in an Infant with Blisters?

How to Deal with Skin Biopsy in an Infant with Blisters?

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