The Büyük Menderes watershed is the largest drainage watershed in Western Anatolia with an area of approximately 26000 km 2 . In the study area, almost 863 landslides occurred, extending over 222 km 2 with a mean landslide area of 0.21 km 2 . In this study, landslide susceptibility assessment was carried out using Arti cial Neural Network method which is one of the data driven methods. Geology, digital elevation model, slope, topographic wetness index, roughness index, plan, pro le curvatures, and proximity to the active faults and rivers were used as landslide conditioning factors. In susceptibility assessments, landslides were separated by 70 % analysis, 15 % test and validation data sets by random selection method. The performance of the landslide susceptibility map was assessed by the area under the receiver operating characteristic curves, error histogram, and confusion matrix, respectively. The area under the receiver operating characteristic curves, analysis, testing, validation, landslides and study ares was found 0.82, 0.84, 0.86, 0.82. The susceptibility map had a high perediction rate in which high and very high susceptible zones corresponded to 26 % of the study area including 82 % of the recorded landslides.