Landscapes of Change: Boccioni's "Stati d'animo" as a General Theory of Models

Kwinter, Sanford; Boccioni, Umberto

doi:10.2307/3171176

Cited by 16 publications

(11 citation statements)

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“…However, mutational landscapes and landscape concepts of sequence-fitness relationships extend much further among multi-molecule systems. For instance genomic landscapes of cancer ( 50 ) and landscapes of whole organism inclusive fitness ( 51 ), even ‘landscapes of change’ ( 52 ). For whole organisms, the landscape metaphor has conceptual limitations ( 53 ), is rarely adequately tested ( 54 ) and seldom extends back to the scale of the effects of specific genome changes ( 55 ).…”

Section: Discussionmentioning

confidence: 99%

Array-based evolution of DNA aptamers allows modelling of an explicit sequence-fitness landscape

Knight

Platt

Rowe

et al. 2008

Nucleic Acids Research

112

138

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Mapping the landscape of possible macromolecular polymer sequences to their fitness in performing biological functions is a challenge across the biosciences. A paradigm is the case of aptamers, nucleic acids that can be selected to bind particular target molecules. We have characterized the sequence-fitness landscape for aptamers binding allophycocyanin (APC) protein via a novel Closed Loop Aptameric Directed Evolution (CLADE) approach. In contrast to the conventional SELEX methodology, selection and mutation of aptamer sequences was carried out in silico, with explicit fitness assays for 44 131 aptamers of known sequence using DNA microarrays in vitro. We capture the landscape using a predictive machine learning model linking sequence features and function and validate this model using 5500 entirely separate test sequences, which give a very high observed versus predicted correlation of 0.87. This approach reveals a complex sequence-fitness mapping, and hypotheses for the physical basis of aptameric binding; it also enables rapid design of novel aptamers with desired binding properties. We demonstrate an extension to the approach by incorporating prior knowledge into CLADE, resulting in some of the tightest binding sequences.

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Section: Discussionmentioning

confidence: 99%

Array-based evolution of DNA aptamers allows modelling of an explicit sequence-fitness landscape

Knight

Platt

Rowe

et al. 2008

Nucleic Acids Research

112

138

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show abstract

“…The indexical act of signifying, he says, consists of a sign that signifies its object by using some physical or existential continuity (signobject relation), and generates a further sign to signify that object (signinterpretant relation). That the interpretant need not be a person but can be another sign is obviously significant in relation to the proliferation of the automated recursive systems mentioned above, and to the possibility that the ordering of sequences of indexes afford for the emergence of what might be called epigenetic surfaces (Kwinter, 1992). What is 14…”

Section: Auto-spatializationmentioning

confidence: 98%

Introduction: The Becoming Topological of Culture

Lury

Parisi

Terranova

2012

Theory, Culture & Society

222

121

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In social and cultural theory, topology has been used to articulate changes in structures and spaces of power. In this introduction, we argue that culture itself is becoming topological. In particular, this 'becoming topological' can be identified in the significance of a new order of spatio-temporal continuity for forms of economic, political and cultural life today. This ordering emerges, sometimes without explicit coordination, in practices of sorting, naming, numbering, comparing, listing, and calculating. We show that the effect of these practices is both to introduce new continuities into a discontinuous world by establishing equivalences or similitudes, and to make and mark discontinuities through repeated contrasts. In this multiplication of relations, topological change is established as being constant, normal and immanent, rather than being an exceptional form, which is externally produced; that is, forms of economic, political and cultural life are identified and made legible in terms of their capacities for continuous change. Outlining the contributions to this Special Issue, the introduction discusses the meaning of topological culture and provides an analytic framework through which to understand its implications.

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“…With the development of fractal mathematics in the 1970s by Mandelbrot and of computers capable of handling ever-larger data sets, the technical capacity for exploring autopoietic processes, complex adaptive systems, and the chaotic environment in which they unfold expanded and the range of application widened. By the mid-199Os, the approach is being used to study art (e.g., Kwinter, 1992), the economy (e.g., Arthur, 1990;Katsenelinboigen, 1992), urban systems (e.g., Allen, 1982), literature (e.g., Hayles, 199 1;Martine, 1992), media effects (Enzensberger, 1992), and other social systems as well as the organizational change analyses (e.g., Cameron & Quinn, 1988;Meyer, Brooks, & Goes, 1990;von Foerster, 1984;Weick, 1977) that are synthesized and discussed below. Jantsch (1989) argues it is not coincidence that our understanding of self-organizing systems and greater appreciation for the relationship between order and chaos developed concurrently with scientific discoveries that vastly expanded our sense of the universe.…”

Section: Systems Catastrophes Chaosmentioning

confidence: 99%

The autopoietic state: Communication and democratic potential in the net

Braman

1994

J. Am. Soc. Inf. Sci.

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The relationship between the practice of democracy and the use of new information technologies is dependent upon the technologies of communication and information, rules regarding the use of those technologies, and the nature of the entity making rules regarding those technologies. Since today developments in all three of these areas are turbulent, this article looks to social theory that deals with turbulence and chaos as a way of understanding the democratic potential in the qualitatively different network society. The streams of literature drawn upon include second-order cybernetics and chaos theory, organizational sociology, and the literature on the state. The concept of the autopoietic state is developed as a basis for determining appropriate communication policy principles for maximizing the democratic potential in the network environment.

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Landscapes of Change: Boccioni's "Stati d'animo" as a General Theory of Models

Cited by 16 publications

References 0 publications

Array-based evolution of DNA aptamers allows modelling of an explicit sequence-fitness landscape

Array-based evolution of DNA aptamers allows modelling of an explicit sequence-fitness landscape

Introduction: The Becoming Topological of Culture

The autopoietic state: Communication and democratic potential in the net

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