This chapter introduces, by literature reviews, the issue of the links and processes behind climate change, environmental change, and socio-culture change in the past at the ancient Silk Road region. Analyses of the changes of the socioenvironment system in this area enhance our understanding on the regular patterns of coupled natural and social evolution, and is thus of important theoretical and practical significance. We argue that the cross-cutting theme has been to reach beyond simple explanations of environmental or human determinism, but social resilience under environmental impacts. Studies indicate both that climate conditions significantly influence human socio-cultural systems and that the socio-culture systems are certainly resilient to climate impacts. This chapter also summarizes the scope of all chapters in this book by illustrating the specific topics, research areas, focused periods and their inner relationships. The conclusion further summarizes the recent research states on past socio-environmental dynamics and the findings achieved in this book, as well as some outlooks.