Landscape of transcriptome‐wide m6A modification in diabetic liver reveals rewiring of PI3K‐Akt signaling after physical exercise
Cong Chen,
Cai Jiang,
Ting Lin
et al.
Abstract:AimType 2 diabetes mellitus (T2DM) is one of the most common diseases, and epigenetic modification N6‐methyladenosine (m6A) is essential for transcriptional modulation involved in its development. However, the precise role and landscape of transcriptome‐wide m6A alterations in molecular adaptations after physical exercise have yet to be fully elucidated.MethodsFour‐week‐old male C57BL/6J mice received a high‐fat diet (HFD) for 12 weeks to establish a diabetic state, and HFD mice were simultaneously subjected t… Show more
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