Landscape of blaNDM genes in Enterobacteriaceae

Kikuchi, Yuta; Matsui, Hidehito; Asami, Yukihiro; Kuwae, Asaomi; Inahashi, Yuki; Hanaki, Hideaki; Abe, Akio

doi:10.1038/s41429-022-00553-3

Cited by 9 publications

(6 citation statements)

References 18 publications

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“…In China, IncX3 is the most common plasmid type carrying bla NDM , suggesting that IncX3 plasmids may be the primary vehicles mediating the dissemination of bla NDM in China [ 138 , 139 ]. An analysis of all NDM-1 gene sequences revealed the consistent presence of the IS Aba125 sequence in the upstream 100 bp region of the bla NDM-1 gene, indicating that the bla NDM-1 gene likely first appeared in A. baumannii , mediated by IS Aba125 [ 140 , 141 ]. Furthermore, downstream of the bla NDM-1 gene, there is a consistent presence of the ble MBL gene, conferring resistance to bleomycin [ 140 ].…”

Section: Escherichia Colimentioning

confidence: 99%

“…An analysis of all NDM-1 gene sequences revealed the consistent presence of the IS Aba125 sequence in the upstream 100 bp region of the bla NDM-1 gene, indicating that the bla NDM-1 gene likely first appeared in A. baumannii , mediated by IS Aba125 [ 140 , 141 ]. Furthermore, downstream of the bla NDM-1 gene, there is a consistent presence of the ble MBL gene, conferring resistance to bleomycin [ 140 ]. Other bla NDM variants share a similar genetic background with bla NDM-1 , often associated with upstream IS Aba125 (complete or truncated) and downstream ble MBL [ 142 ].…”

Section: Escherichia Colimentioning

confidence: 99%

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ESKAPE in China: epidemiology and characteristics of antibiotic resistance

Luo,

Lu,

Chen

et al. 2024

Emerging Microbes & Infections

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The escalation of antibiotic resistance and the diminishing antimicrobial pipeline have emerged as significant threats to public health. The ESKAPE pathogens – Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp. – were initially identified as critical multidrug-resistant bacteria, demanding urgently effective therapies. Despite the introduction of various new antibiotics and antibiotic adjuvants, such as innovative β-lactamase inhibitors, these organisms continue to pose substantial therapeutic challenges. People’s Republic of China, as a country facing a severe bacterial resistance situation, has undergone a series of changes and findings in recent years in terms of the prevalence, transmission characteristics and resistance mechanisms of antibiotic resistant bacteria. The increasing levels of population mobility have not only shaped the unique characteristics of antibiotic resistance prevalence and transmission within People’s Republic of China but have also indirectly reflected global patterns of antibiotic-resistant dissemination. What’s more, as a vast nation, People’s Republic of China exhibits significant variations in the levels of antibiotic resistance and the prevalence characteristics of antibiotic resistant bacteria across different provinces and regions. In this review, we examine the current epidemiology and characteristics of this important group of bacterial pathogens, delving into relevant mechanisms of resistance to recently introduced antibiotics that impact their clinical utility in China.

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Section: Escherichia Colimentioning

confidence: 99%

Section: Escherichia Colimentioning

confidence: 99%

ESKAPE in China: epidemiology and characteristics of antibiotic resistance

Luo,

Lu,

Chen

et al. 2024

Emerging Microbes & Infections

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“…[30,31] Furthermore, a wide variety of bacteria ranging across various genera, such as Pseudomonas or members of the Enterobacteriaceae family, harbor different bla NDM variants. [24,30,32] Hence, the phylogenetic history of bla NDM is more readily associated with MGEs than with specific lineages of organisms. [33] And yet, even at that finer-grained level of analysis, there are no perfect correlations.…”

Section: A Case Study To Illustrate Insights Of An Evosystemic Approa...mentioning

confidence: 99%

“…Furthermore, ble MBL has a stabilizing effect on its genetic neighborhood. [41] This whole picture illustrates the irreducible context-dependence of the evolutionary successes of bla NDM : it relies on its genetic neighborhood (ble MBL , but also, for example, the ISAba125 insertion sequence [28,32] ), on the presence of infectable macroorganisms (that react and that warrant use of antibiotic substances) and on the nosocomial context where bleomycin is occasionally present (such that the bla NDM -ble MBL tandem's fitness increasing capacities become relevant).…”

Section: A Case Study To Illustrate Insights Of An Evosystemic Approa...mentioning

confidence: 99%

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The evosystem: A centerpiece for evolutionary studies

Papale,

Not,

Bapteste

et al. 2024

BioEssays

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In this paper, we redefine the target of evolutionary explanations by proposing the “evosystem” as an alternative to populations, lineages and species. Evosystems account for changes in the distribution of heritable variation within individual Darwinian populations (evolution by natural selection, drift, or constructive neutral evolution), but also for changes in the networks of interactions within or between Darwinian populations and changes in the abiotic environment (whether these changes are caused by the organic entities or not). The evosystem can thereby become a centerpiece for a redefined evolutionary science, that is, evolutionary studies, that apprehends through a single framework the variety of evolutionary processes that lie at various scales. To illustrate the importance of this broadened perspective on evolution, we use a case of antimicrobial resistance evolution: the spread of the blaNDM gene family and the related resistance to carbapenem antibiotics observed globally, and show how evolutionary studies can contribute to answering contemporary socially relevant challenges.

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